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Riemerella anatipestifer and escherichia coli bigeminal inactivated vaccine, and preparation method thereof

A technology of Escherichia coli and dual inactivated vaccines, applied in antibacterial drugs, pharmaceutical formulations, bacterial antigen components, etc., can solve problems such as Escherichia coli disease, duck flock death, and economic loss of farms , to achieve the effect of simple preparation method, high prevention efficiency and stable product effect

Inactive Publication Date: 2010-04-07
广东永顺生物制药股份有限公司
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  • Abstract
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AI Technical Summary

Problems solved by technology

After the occurrence of infectious serositis in ducks, duck Escherichia coli disease is often secondary, resulting in a large number of ducks dying, causing serious economic losses to the farm

Method used

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Examples

Experimental program
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Effect test

Embodiment Construction

[0021] The seed bacteria used in the Riemerella anatipestifer and Escherichia coli dual inactivated vaccine of the present invention are strictly screened out through serological investigation. Riemerella anatipestifer was isolated and identified 148 strains of Riemerella anatipestifer through a series of experiments such as isolation and purification of bacteria, cloning of RA 16sRNA gene, biochemical experiments, animal experiments and serology, among which RA type 1 There were 56 strains (accounting for 37.84% of the isolates), 32 strains of RA type 2 (accounting for 21.62% of the isolates), and 60 strains of other serotypes (accounting for 40.54% of the isolates). Two serotypes, RA1 and RA2, had absolute advantages among the isolated bacteria. After the immunogenicity detection of the existing RA1 and RA2 strains, one strain of Riemerella anatipestifer each with good immunogenicity was successfully screened out as a candidate strain for vaccine preparation. At the same ti...

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Abstract

The invention belongs to the technical field of biological products for veterinary uses, in particular to a method for preparing a riemerella anatipestifer and escherichia coli bigeminal inactivated vaccine and a preparation method thereof. The vaccine is prepared by inoculating riemerella anatipestifer I type, riemerella anatipestifer II type and escherichia coli O78 type which have excellent immunogenicity into a culture medium for culture, using formaldehyde solution to inactivate the bacteria and emulsifying the resulting product by an oil adjuvant. The bigeminal inactivated vaccine is used for preventing and controlling infectious serositis and colibacillosis of a duck. The preparation method of the vaccine has a simple operation; and the prepared vaccine has stable performance and can effectively prevent and control the infectious serositis and the colibacillosis of the duck.

Description

technical field [0001] The invention belongs to the technical field of veterinary biological products, and more specifically relates to a dual inactivated vaccine of Riemerella anatipestifer and Escherichia coli and a preparation method thereof. Background technique [0002] Duck infectious serositis is an acute or chronic contact and septic infectious disease caused by Riemerella anatipestifer (RA). Duck Escherichia coli (Escherchia coli) is a hemorrhagic, exudative and septic infectious disease caused by pathogenic Escherichia coli. Ducks of different breeds, ages and sexes can be infected, and the two diseases are usually mixed and co-infected. After the occurrence of infectious serositis in ducks, duck Escherichia coli disease is often secondary, leading to a large number of deaths of ducks and causing serious economic losses to the farms. [0003] Duck infectious serositis, also known as Riemerella anatipestifer, is one of the most important infectious diseases causin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/116A61K39/108A61K39/02A61P31/04
Inventor 张毓金齐冬梅林旭野巫月生赖月辉李嘉爱蔡植松
Owner 广东永顺生物制药股份有限公司
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