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Paracetamol sustained-release double-layer tablets and preparation method thereof

A technology for acetaminophen and sustained-release tablets, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, and pill delivery, and can solve problems such as unclear mechanisms of action

Inactive Publication Date: 2010-03-03
COSCI MED TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although acetaminophen has been used clinically for a hundred years, its mechanism of action is still not very clear

Method used

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  • Paracetamol sustained-release double-layer tablets and preparation method thereof
  • Paracetamol sustained-release double-layer tablets and preparation method thereof
  • Paracetamol sustained-release double-layer tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] prescription

[0047] Immediate release layer:

[0048] Acetaminophen 325g

[0049] Pregelatinized starch 85g

[0050] Sodium carboxymethyl starch 20g

[0051] 10% Povidone K 30 Aqueous solution

[0052] Magnesium Stearate 6.5g

[0053] Slow release layer:

[0054] Acetaminophen 325g

[0055] Hypromellose K 4 7g

[0056] Microcrystalline Cellulose 42g

[0057] 21g pregelatinized starch

[0058] 10% Povidone K 30 Aqueous solution

[0059] Magnesium Stearate 6g

[0060] A total of 1000 pieces were made

[0061] Film-forming material:

[0062] Opadry (G-85-white) 20g

[0063] Add pure water to 100ml

[0064] Preparation Process

[0065] (1) Preparation process of plain tablets

[0066] (1.1) Preparation of immediate-release granules

[0067] Pass each component in the prescription through a 100-mesh sieve, and set aside. Fully mix the prescription amount of pregelatinized starch and 1 / 2 amount of carboxymethyl starch sodium, and then mix it with ac...

Embodiment 2

[0075] prescription

[0076] Immediate release layer:

[0077] Acetaminophen 325g

[0078] 40g pregelatinized starch

[0079] Microcrystalline Cellulose 40

[0080] Sodium carboxymethyl starch 20g

[0081] 10% Povidone K 30 Aqueous solution

[0082] Magnesium Stearate 6.5g

[0083] Slow release layer:

[0084] Acetaminophen 325g

[0085] Hypromellose K 4 7g

[0086] Microcrystalline Cellulose 32g

[0087] 32g pregelatinized starch

[0088] 10% Povidone K 30 Aqueous solution

[0089] Magnesium Stearate 6g

[0090] A total of 1000 pieces were made

[0091] Film-forming material:

[0092] Opadry (G-85-white) 20g

[0093] Add pure water to 100ml

[0094] Preparation Process

[0095] (1) Preparation process of plain tablets

[0096] (1.1) Preparation of immediate-release granules

[0097] Pass each component in the prescription through a 100-mesh sieve, and set aside. Fully mix the prescription amount of pregelatinized starch, microcrystalline cellulo...

Embodiment 3

[0105] prescription

[0106] Immediate release layer:

[0107] Acetaminophen 325g

[0108] 30g pregelatinized starch

[0109] Microcrystalline Cellulose 30

[0110] Sodium carboxymethyl starch 20g

[0111] 10% Povidone K 30 Aqueous solution

[0112] Magnesium Stearate 6.5g

[0113] Slow release layer:

[0114] Acetaminophen 325g

[0115] Hypromellose K 4 9g

[0116] Microcrystalline Cellulose 66g

[0117] 10% Povidone K 30 Aqueous solution

[0118] Magnesium Stearate 6g

[0119] A total of 1000 pieces were made

[0120] Film-forming material:

[0121] Opadry (G-85-white) 20g

[0122] Add pure water to 100ml

[0123] Preparation Process

[0124] (1) Preparation process of plain tablets

[0125] (1.1) Preparation of immediate-release granules

[0126] Pass each component in the prescription through a 100-mesh sieve, and set aside. Fully mix the prescription amount of pregelatinized starch, microcrystalline cellulose, and 1 / 2 amount of sodium carboxymeth...

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PUM

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Abstract

The invention relates to paracetamol sustained-release double-layer tablets and a preparation method thereof. The paracetamol sustained-release double-layer tablets are characterized in that: the double-layer tablets consist of a quick release layer and a sustained release layer, and are coated with coating films. The paracetamol sustained-release double-layer tablets provided by the invention have the characteristics of convenient administration, lasting effect, stable curative effect, small toxic and side effect and the like.

Description

technical field [0001] The invention relates to a paracetamol double-layer sustained-release tablet and a preparation method thereof, which is characterized in that a double-layer tablet is jointly compressed by an immediate-release layer and a slow-release layer, and the double-layer tablet is coated with a coating film. in the field of medicine technical background [0002] Acetaminophen is a clinically proven effective analgesic and antipyretic drug. It produces analgesic effect by increasing the pain threshold, and antipyretic effect by acting on the heat regulation center of the hypothalamus. The analgesic and antipyretic effects of acetaminophen are comparable to aspirin, but without the side effects associated with aspirin and aspirin-containing products. [0003] Although acetaminophen has been used clinically for a hundred years, its mechanism of action is still not very clear. In the past, it was believed that non-steroidal anti-inflammatory drugs mainly inhibit...

Claims

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Application Information

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IPC IPC(8): A61K9/24A61K9/30A61K31/167A61P29/00A61P25/04
Inventor 李育巧
Owner COSCI MED TECH CO LTD
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