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Medicinal composition for treating skin injury and ulcer and application thereof

A composition and drug technology, applied in the direction of drug combination, skin diseases, active ingredients of hydroxyl compounds, etc., can solve the problems of clinical promotion and application limitations, unbearable pain for patients, unsatisfactory effects, etc., to improve microcirculation, promote Wound healing, improve tissue oxygen supply effect

Inactive Publication Date: 2010-02-17
安徽省华鼎生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the commonly used traditional Chinese medicine external preparations such as powders, lotions, plasters, patches, ointments, ointments, etc., mostly simply remove putrefaction and promote muscle growth or antibacterial and anti-inflammatory, all rely on drugs to "remove putrefaction" and "grow muscle". , the effect is not very satisfactory, the onset of effect is slow, the course of disease is long, the pain of the patient is unbearable, and the clinical promotion and application are greatly limited

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Prescription: calcined gypsum 60g, dried blood 25g, borneol 25g, artificial musk 5g

[0048] Comfrey 60g Catechin 50g Collagen 20g

[0049] Preparation method: add 4 times the amount of the above seven flavors and comfrey with 70% ethanol to reflux and extract twice, filter, combine, recover ethanol under reduced pressure, concentrate, dry, pulverize, and set aside; four flavors such as calcined gypsum are coarsely crushed, and passed through a 20-mesh standard sieve , ultrafine pulverization in a vibrating ultrafine pulverizer for 25 minutes to obtain ultrafine powder, which is set aside. Separately take 600g of vaseline and 150g of lanolin, heat at 150°C for 1 hour, filter, let cool to 50°C, add the above-mentioned comfrey dry paste fine powder, ultrafine powder and collagen fine powder 20g, mix well, pack separately, and prepare into an ointment.

[0050] Note: Collagen uses donkey skin as raw material, and undergoes bionic enzymolysis method (i.e., pepsin en...

Embodiment 2

[0052] Prescription: blood dried fruit 90g borneol 50g collagen 10g collagen 5g

[0053] Preparation method: the above-mentioned four flavors, dried blood and borneol are coarsely crushed, passed through a 20-mesh standard sieve, and ultrafinely pulverized in a vibrating ultrafine pulverizer for 20 minutes to obtain ultrafine powder, which is set aside. Separately take 640g of vaseline, 80g of lanolin and appropriate amount of liquid paraffin, heat at 150°C for 1 hour, filter, let cool to 50°C, add the above ultrafine powder, collagen and collagen fine powder, a total of 15g, and put it in a vibrating ultrafine pulverizer Mix in medium for 10 minutes, discharge, subpackage to make ointment.

[0054] Note: Collagen is made from gelatin, fully hydrolyzed by papain and trypsin, and its relative molecular weight is below 20kD. Collagen is made from pigskin and cowhide, the pH is adjusted to 7.0 with acetic acid, and it is obtained by enzymatic hydrolysis of figs.

Embodiment 3

[0056] Prescription: Chuanxiong 90g, frankincense 50g, myrrh 50g, dried 30g

[0057] Bletilla striata 125g Geranium 125g Collagen 30g

[0058] Preparation method: the above-mentioned Qiwei, Chuanxiong, Baiji and Geranium are decocted in water twice, each time for 2 hours, the decoctions are combined, filtered, concentrated, dried, crushed, and set aside; eye, spare. Take 10g of carbomer, add water to swell for 24 hours, add triethanolamine to adjust the pH to 8.0, stir well, add the above-mentioned dry paste powder, frankincense and other fine powder and collagen fine powder 30g, and add water to 1000g, stir well, remove air bubbles to make a gel.

[0059] Note: Collagen is made from pigskin and fully enzymolyzed with trypsin and neutral pepsin. The relative molecular weight is below 10kD.

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PUM

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Abstract

The invention discloses a medicinal composition for treating skin injury and ulcer diseases, and belongs to the field of Chinese medicament. The medicinal composition consists of collagen and Chinesemedicaments for fighting bacterium, diminishing inflammation, removing putrefaction and promoting tissue regeneration such as angelica, Szechuan lovage rhizome, salvia root and the like which are prepared into a plurality of dosage forms by matching the prior art. The technology overcomes the defects that the prior preparations for the trauma department have extremely slow response, longer treatment course, adhesion with the skin, influence on scab cicatrization and the like, and has quick and remarkable treatment effect on various skin diabrosis diseases such as mechanical wound, burn / scald,bedsore, chronic leg ulcer, diabetic foot or cancerous ulcer and the like.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating various skin damage and ulcer diseases, which is composed of collagen and traditional Chinese medicines for antibacterial, anti-inflammation, decay-removing and muscle-generating, and belongs to the field of traditional Chinese medicines. Background technique [0002] Various diseases characterized by skin damage or ulcers mainly include various types of mechanical trauma, burns, decubitus ulcers, chronic lower ulcers, diabetic foot, cancerous ulcers, etc., because these diseases often cause skin surface defects, resulting in Skin lesions that reach deep into the dermis or deeper are often lingering and difficult to heal, and the course of disease is long. It is recognized by doctors as an intractable disease. At present, there is no ideal treatment plan. Most of them stop bleeding and / or antibacterial and anti-inflammatory, and remove putrefaction and promote muscle growth. The combine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61P17/02A61K31/045A61K31/122A61K31/125A61K33/06A61K33/30A61K35/56A61K36/185A61K36/324A61K36/328A61K36/48A61K36/739A61K36/889A61K36/898A61K35/618
Inventor 武建卓柴金苗
Owner 安徽省华鼎生物科技有限公司
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