Device and method for combined use of molecular imprinting solid phase microextraction and hollow fiber liquid phase microextraction, and application thereof

Abstract

The invention discloses a device and a method for the combined use of molecular imprinting solid phase microextraction and hollow fiber liquid phase microextraction, and the application thereof. The device consists of a solid phase microextraction device, a molecular imprinting solid phase microextraction probe, a hollow fiber membrane, an extraction bottle and a stirrer. The molecular imprintingsolid phase microextraction probe is inserted in to a hollow fiber membrane cavity containing organic solvent, fixed and then directly positioned into a sample solution to be measured for purpose of liquid-solid phase synchronous microextraction. During the microextraction, analytes permeate the hollow fiber membrane, are then enriched in the organic solvent and then undergo secondary extraction and enrichment under the action of the molecular imprinting solid phase microextraction probe. The device is simple, operates conveniently, facilitates the combined use with an analyzer, is suitable for the separation and enrichment of organics with trace amounts in complex water phase samples obtained from the fields such as environment, food, medicine, biology and the like.

Description

technical field [0001] The invention belongs to the field of analytical chemical sample pretreatment, and in particular relates to a molecular imprinted solid phase microextraction-hollow fiber liquid phase microextraction combined device, method and application, and is suitable for trace amounts in complex aqueous phase samples such as environment, food, medicine and biology. Separation and enrichment of organic matter. Background technique [0002] Liquid-phase microextraction (LPME) is a miniaturized solvent extraction technology developed on the basis of liquid-liquid extraction technology. It has high enrichment efficiency, only uses slightly upgraded organic solvents, and is environmentally friendly. The liquid phase microextraction technology with hollow fiber as the carrier makes microextraction in the porous hollow fiber cavity without direct contact with the sample solution, avoiding the loss of solvent, and because particulate impurities and some macromolecules ca...

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Problems solved by technology

[0004] The object of the present invention is to overcome the above-mentioned problems existing in the existing liquid phase microextraction and molecularly imprinted solid phase microextraction, and provide a novel molecularly imprinted solid phase microextraction-hollow fiber liquid phase microextraction combined device, It can combine the high selectivity of molecularly imprinted solid-phase microextraction and the advantages of anti-pollution of hollow fiber liquid-phase microextraction. The analyte is enriched by secondary extraction, the selectivity and sensitivity are improved, and it can overcome the advantages of molecularly imprinted solid-phase microextraction. Disadvantages of low selectivity of direct aqueous phase extraction

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