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Application of Chinese medicinal composition in preparing medicament for treating diabetic nephropathy

A composition and traditional Chinese medicine technology, applied in the directions of drug combination, urinary system diseases, non-living material medical raw materials, etc., can solve problems such as the application of undisclosed pharmaceutical compositions, achieve no drug dependence and tolerance, precise curative effect, No adverse effects

Active Publication Date: 2012-11-14
HEBEI YILING MEDICINE INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patent does not disclose the application of the pharmaceutical composition in the preparation of drugs for the treatment of diabetic nephropathy

Method used

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  • Application of Chinese medicinal composition in preparing medicament for treating diabetic nephropathy
  • Application of Chinese medicinal composition in preparing medicament for treating diabetic nephropathy
  • Application of Chinese medicinal composition in preparing medicament for treating diabetic nephropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] In order to facilitate the application of the Chinese medicine composition in the treatment of diabetic nephropathy, the Chinese medicine composition is prepared as a capsule

[0033] prescription:

[0034] Ginseng 89g Ophiopogon japonicus 112g Cornus officinalis 224g Salvia miltiorrhiza 224g

[0035] Fried Suanzaoren 186g, Sangjisheng 186g, Radix Paeoniae Rubra 89g, Ground Beetle 75g

[0036] Gansong 89g Coptidis 45g Southern Schisandra 67g Keel 149g

[0037] Preparation:

[0038] a) In the above prescription, ginseng was extracted three times with 70% ethanol under reflux, the first time was 3 hours, and each subsequent time was 2 hours, the extracts were combined, filtered, ethanol was recovered, concentrated, dried, crushed into fine powder, and set aside;

[0039] b) In the above prescription, Schisandra chinensis, Cornus officinalis, Salvia miltiorrhiza, Coptis chinensis, and Gansong are extracted three times with 70% ethanol under reflux, and the extracts are ...

Embodiment 2

[0045] In order to facilitate the application of the Chinese medicine composition in the treatment of diabetic nephropathy, the Chinese medicine composition is prepared as a tablet

[0046] prescription:

[0047] Ginseng 45g Ophiopogon japonicus 112g Cornus officinalis 224g Salvia miltiorrhiza 225g Fried jujube seed 186g

[0048]Sangjisheng 186g Radix Paeoniae Rubra 89g Gansong 45g Wood Beetle 35g Coptidis 45g

[0049] Southern schisandra 67g, keel 149g.

[0050] Preparation:

[0051] a) In the above prescription, ginseng was extracted three times with 70% ethanol under reflux, the first time was 3 hours, and each subsequent time was 2 hours, the extracts were combined, filtered, ethanol was recovered, concentrated, dried, crushed into fine powder, and set aside;

[0052] b) In the above prescription, Schisandra chinensis, Cornus officinalis, Salvia miltiorrhiza, Coptis chinensis, and Gansong are extracted three times with 70% ethanol under reflux, and the extracts are comb...

Embodiment 3

[0058] In order to facilitate the application of the Chinese medicine composition in the treatment of diabetic nephropathy, the Chinese medicine composition is prepared as granules

[0059] prescription:

[0060] Ginseng 175g Ophiopogon japonicus 192g Cornus officinalis 421g Salvia miltiorrhiza 440g Fried jujube seed 395g

[0061] Sangjisheng 396g Radix Paeoniae Rubra 188g Ground Beetle 98g Gansong 188g Coptidis 85g

[0062] Southern schisandra 147g, keel 278g.

[0063] Preparation:

[0064] a) In the above prescription, ginseng was extracted three times with 70% ethanol under reflux, the first time was 3 hours, and each subsequent time was 2 hours, the extracts were combined, filtered, ethanol was recovered, concentrated, dried, crushed into fine powder, and set aside;

[0065] b) In the above prescription, Schisandra chinensis, Cornus officinalis, Salvia miltiorrhiza, Coptis chinensis, and Gansong are extracted three times with 70% ethanol under reflux, and the extracts a...

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Abstract

The invention provides application of a Chinese medicinal composition in preparing a medicament for treating diabetic nephropathy. The Chinese medicinal composition comprises ginseng, dwarf lilyturf root, dogberry, salvia miltiorrhiza, fried spina date seed, Chinese taxillus twig, red paeony root, ground beeltle, nardostachyos root and rhizome and other Chinese medicaments. The clinical experiments prove that Chinese medicinal composition has obvious clinical curative effect of treating the diabetic nephropathy.

Description

technical field [0001] The invention relates to the application of a traditional Chinese medicine composition in the preparation of medicines for treating diabetic nephropathy, which belongs to the application field of Chinese herbal medicines. Background technique [0002] Diabetic nephropathy (diabetic nephropathy, DN) is one of the most serious and common chronic complications of diabetes, and it is also the main cause of death in diabetic patients. Once a patient develops microalbuminuria, their renal function will decline irreversibly and progressively, often until end-stage renal failure. [0003] Hyperglycemia leading to metabolic abnormalities and hemodynamic changes is the main cause of diabetic nephropathy. The main pathological changes of diabetic nephropathy are glomerulosclerosis, tubulointerstitial fibrosis, renal tubular epithelial cells and vascular damage. Manifested as glomerular basement membrane thickening and mesangial matrix hyperplasia, nodular glome...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8968A61K9/48A61K9/20A61K9/16A61K9/14A61K9/10A61P3/10A61P13/12A61K35/64A61K35/02
Inventor 李向军安军永王超郑立发
Owner HEBEI YILING MEDICINE INST
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