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Meloxicam tablet, production technology and purposes thereof

A technology of meloxicam and tablet cores, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, pill delivery, etc., can solve the problems of unsatisfactory curative effect, and achieve good anti-inflammatory and pain-relieving curative effect, The effect of stable blood drug concentration and less frequency of medication

Active Publication Date: 2010-01-06
FEIMA PHARMA NANTONG CITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Existing drugs for the treatment of rheumatoid arthritis and painful osteoarthritis (arthrosis, degenerative joint disease) have unsatisfactory aspects such as curative effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0036] (1) Making tablet cores: pass meloxicam, lactose, pregelatinized starch, and low-substituted hydroxypropyl cellulose through a 100-mesh sieve, and add them into a wet mixing granulator according to an equal-volume increasing method and mix evenly to obtain a mixture powder; dissolve polysorbate-80 in 30-50 times of ethanol, add it to the above mixed powder, mix for 1 minute, then add 12% pregelatinized starch for pulping to the mixed powder to make 18-40 Mesh granules, dried at 60-70°C, granulated with a 24-mesh sieve, collected when the water content was 1.0-3.0%, and prepared into tablet cores for later use;

[0037] (2) Coating: the stomach-soluble film coating premix is ​​formulated with 80% ethanol into a 11% suspension, stirred and mixed for 60 minutes for later use; 2~3 rpm, adjust the distance of the spray gun to 30~40cm away from the tablet bed, start preheating the tablet core, the temperature of the tablet core is about 40~50℃, the spray pressure is 0.5~0.6MP...

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PUM

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Abstract

The invention discloses a Meloxicam tablet, a production technology and purposes thereof. The Meloxicam tablet consists of Meloxicam, lactose, pregelatinized starch, low-substitute hyprolose, polysorbate 80, 12% of pregelatinized starch for flushing syrup, superfine silica gel powder, magnesium stearate, alcohol and gastric-solubility film coating premixer. The production method of the Meloxicam tablet comprises the following steps: manufacturing tablet cores and coatings, and the like. The Meloxicam tablet treats 125 cases of rheumatoid arthritis, and the anti-inflammatory and pain-relieving curative effects are good, while the curative effect on blood sedimentation is little, and the total effective rate achieves 84%. The invention has the characteristics of few medical taking times, stable blood and medicine concentration, long duration period, and the like.

Description

Technical field: [0001] The present invention relates to a medicine. Background technique: [0002] The existing medicines for treating rheumatoid arthritis and painful osteoarthritis (arthrosis, degenerative joint disease) have unsatisfactory aspects such as curative effect. Invention content: [0003] The object of the present invention is to provide a meloxicam tablet with good effect in treating rheumatoid arthritis and painful osteoarthritis, its production process and application. [0004] Technical solution of the present invention is: [0005] A kind of meloxicam tablet is characterized in that: every 1000 is made up of following weight components: [0006] Meloxicam 7.5g [0007] Lactose 16.3 ~ 130 grams [0008] 8.0-48 grams of pregelatinized starch [0009] Low-substituted hydroxypropyl cellulose 2.5-20 grams [0010] Polysorbate-80 0.1~0.8g [0011] 4.5-30 grams of pregelatinized starch for pulping with 12% concentration [0012] Micropowder silica gel ...

Claims

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Application Information

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IPC IPC(8): A61K9/28A61K31/5415A61K47/38A61P29/00A61P19/04A61P19/02
Inventor 康汝祥
Owner FEIMA PHARMA NANTONG CITY
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