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Acidic oligosaccharide having weight-reducing and lipid-lowering effects and application thereof

A technology for reducing blood lipids and oligosaccharides, which is applied in the direction of medical preparations containing active ingredients, applications, organic active ingredients, etc. It can solve the problems of high pectin viscosity, application restrictions, and inconvenient use, and achieve lower blood lipids and good solubility Sexuality, the effect of regulating lipid metabolism

Inactive Publication Date: 2009-12-30
LIAONING UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although, it has been reported that pectin, as a dietary fiber, can reduce blood lipids by reducing the absorption of fat and cholesterol in the intestine or increasing the excretion of bile acids (Eastwood M.A., Annu.Rev.Nutr., 12, 19-35 , 1992), but due to the high viscosity of pectin, it is inconvenient to use, so its application is limited to a certain extent

Method used

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  • Acidic oligosaccharide having weight-reducing and lipid-lowering effects and application thereof
  • Acidic oligosaccharide having weight-reducing and lipid-lowering effects and application thereof
  • Acidic oligosaccharide having weight-reducing and lipid-lowering effects and application thereof

Examples

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Effect test

Embodiment 1

[0017] An acidic oligosaccharide with weight loss and blood fat lowering effects, prepared according to the following method:

[0018] (1) Take an aqueous solution of pectin (commercially available pectin) with a mass percent concentration of 1%, adjust the pH to 3 with acetic acid, and decompose it at 110° C. for 3 hours to obtain a pectin decomposition product;

[0019] (2) Treat the above-mentioned pectin decomposition product with a hollow fiber membrane, recover the oligosaccharide mixture with a molecular weight below 6000 Daltons, and recover the oligosaccharide mixture with a molecular weight of 200 to 6000 with a nanofiltration membrane, and use Bio-gel P-2 and The pectin acid oligosaccharides with a coincidence degree of 2-20 were separated by Sephadex G-25 gel column.

Embodiment 2

[0021] A pectin acid oligosaccharide with weight loss and blood fat lowering effects, prepared according to the following method:

[0022] (1) Obtaining pectin: after the apple juice is processed, the juice residue is passed through water (50-100° C.), extracted for 3 hours, filtered, and the filtrate is precipitated with ethanol according to the conventional pectin recovery method, and the apple fruit is recovered. glue.

[0023] (2) Take an aqueous pectin solution with a mass percent concentration of 2%, adjust the pH to 2 with hydrochloric acid (or sulfuric acid), and decompose at 90°C for 24 hours to obtain a pectin decomposition product;

[0024] (3) The pectin decomposition product is treated with a ceramic membrane, and the oligosaccharide mixture with a molecular weight of 6000 Daltons or less is reclaimed, and the oligosaccharide mixture with a molecular weight of 200 to 6000 Daltons is reclaimed with a nanofiltration membrane, and gelled with Sephadex G-25. Pectin a...

Embodiment 3

[0026] An acidic oligosaccharide with weight loss and blood fat lowering effects, prepared according to the following method:

[0027] (1) Obtaining pectin: Pass the citrus peels through hydrochloric acid (pH 2-6, 50-90°C), extract for 3 hours, filter, and the filtrate is precipitated with ethanol according to the conventional pectin recovery method, and the citrus fruit is recovered. glue.

[0028] (2) Take an aqueous pectin solution with a mass percent concentration of 1%, adjust the pH to 4 with hydrochloric acid (or sulfuric acid), and decompose at 120°C for 15 minutes to obtain a pectin decomposition product;

[0029] (3) The pectin decomposition product is treated with a hollow fiber membrane, and after recovering the oligosaccharide mixture with a molecular weight of 6000 Daltons or less, the oligosaccharide mixture with a molecular weight of 200 to 6000 Daltons is recovered with a nanofiltration membrane, and the bio-gel P-2 and Sephadex G-25 gel column chromatography...

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Abstract

The invention relates to an acidic oligosaccharide having weight-reducing and lipid-lowering effects and application thereof. The adopted technical scheme is that a preparation method of the acidic oligosaccharide is as follows: taking pectin water solution with the weight percentage concentration of 1 percent to 2 percent, regulating pH to 2 to 4, decomposing and reacting the solution for 15 minutes to 24 hours at 90 to 120 DEG C to obtain pectin decomposer, treating the pectin decomposer by a hollow fiber membrane or a ceramic filter membrane, recovering oligosaccharide mixtures with the molecular weight of lower than 6000 daltons, recovering the oligosaccharide mixtures with the molecular weight of 200 to 6000 daltons through a nano-filter membrane, carrying out chromatographic separation by utilizing Bio-gel P-2 gel column or SephadexG-25 gel column or DEAE-Sephadex A-25 anion exchange resin, and carrying out gradient elution by utilizing inorganic salt water solution to obtain the pectin acidic oligosaccharide with the contact ratio of 2 to 20. The acidic oligosaccharide prepared by the invention can be applied to weight-reducing and lipid-lowering health food.

Description

technical field [0001] The invention belongs to the field of functional food, and in particular relates to an acidic oligosaccharide with the functions of reducing weight and reducing blood fat and its application. Background technique [0002] In modern society, hyperlipidemia, high blood pressure, arteriosclerosis, diabetes and other cardiovascular and cerebrovascular diseases are caused by people's partial eclipse, overeating, overeating, lack of exercise, work pressure, old age and other changes in living habits and dietary structure. It has become a major disease that endangers human health. The mortality rate caused by these diseases has also become the second most harmful disease after cancer. At the same time, these diseases have also brought huge burdens to people's physical, mental, economic life and social medical care. At present, although there is no effective treatment for these diseases, food ingredients can be used to improve and regulate the absorption and ...

Claims

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Application Information

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IPC IPC(8): C07H3/06C07H1/00C12P19/14C08B37/06A61P3/04A61P3/06A23L1/29A61K31/702A61K31/732A23L33/00
Inventor 李拖平李苏红王娜郭梅
Owner LIAONING UNIVERSITY
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