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Buprenorphine patch

A technology of buprenorphine hydrochloride and patch, which is applied in the direction of medical preparations of non-active ingredients, sheet delivery, nervous system diseases, etc. It can solve the problems of long-term administration, unsatisfactory patients, and unsatisfactory effects, etc. problem, to achieve the effect of good drug stability, great application value, and good percutaneous absorption effect

Active Publication Date: 2012-10-03
COSMED PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But, because the skin absorbability of (hydrochloride) buprenorphine is low, someone has just proposed to use various absorption accelerators and improves the patch (as patent document Japanese Patent Laid-open 4-217926,7-10754, 7-304672, special table flat 10-512551)
Although these patches improve the skin permeability of the drug, the effect is not satisfactory, the purpose of long-term administration cannot be achieved, and the needs of patients cannot be met.

Method used

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  • Buprenorphine patch
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Examples

Experimental program
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Embodiment 1-3、 comparative example 1～5

[0026] According to the proportion shown in Table 1, add buprenorphine, buprenorphine hydrochloride, diethanolamide laurate, isopropyl myristate, isopropyl palmitate and rosin ester (Arakawa chemical Co., Ltd., rosin ester GA-90AF), uniformly mixed to form a solution for transdermal absorption, and coated on a polyethylene terephthalate (PET) film to control the thickness of the coating film so that the thickness of the film after drying is 100 μm , dried at a temperature of 60° C. for 8 hours, and the transdermal absorption patch was prepared after the solvent evaporated.

[0027] Table 1

[0028]

[0029] In the above table, A is adhesive A; B is adhesive B; C is adhesive DUR-TAC 87-2677; D is adhesive: MASCOS10

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Abstract

The invention provides a buprenorphine hydrochloride and / or buprenorphine patch. A binder layer formed on one face of a flexible backing layer of the patch contains a medicament, a penetration enhancer, a tackifier, an antioxidant and a binder. The medicament is the buprenorphine hydrochloride and / or buprenorphine; the penetration enhancer is a mixture of lauric acid diethanolamide, isopropyl myristate and / or isopropyl palmitate; the tackifier is rosin and / or abietate; the antioxidant is vitamin E and the like; and the binder is acrylate adhesive. The patch has the advantages of good transdermal absorption effect of the medicament, no stimulation to the skin, good medicinal stability and higher application value.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a transdermal absorption patch, in particular to a transdermal absorption patch containing buprenorphine hydrochloride or buprenorphine. Background technique [0002] Due to a variety of reasons, cancer has become one of the main causes of human death due to disease, and cancer patients basically experience pain such as cancer pain. Therefore, in cancer treatment, the treatment of cancer pain is particularly important. Among the therapeutic drugs for relieving cancer pain, non-narcotic buprenorphine hydrochloride and / or buprenorphine are more effective and have been used as injections and suppositories. However, the medicine of this type of dosage form will bring side effects of injection pain and uncomfortable feeling when the suppository is used to the patient. In recent years, studies have been made on skin adhesives for the purpose of eliminating this side effect. But, becau...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/485A61K9/70A61K47/16A61K47/14A61K47/46A61K47/32A61P25/04
Inventor 权英淑神山文男
Owner COSMED PHARMA
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