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Use of coherent raman techniques for medical diagnostic and therapeutic purposes, and calibration techniques for same

A technology of Raman spectroscopy and target analytes, which is applied in the field of Raman scattering to study the spectrum of molecules, can solve problems such as not raised, and achieve the effects of reducing pain and discomfort, reducing pregnancy loss, and reducing mortality.

Inactive Publication Date: 2009-12-16
ARETAIS
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Problems solved by technology

Currently, there is no non-invasive method of detecting glucose concentration that can accurately and quantitatively measure glucose levels in diabetic patients or is not proposed

Method used

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  • Use of coherent raman techniques for medical diagnostic and therapeutic purposes, and calibration techniques for same
  • Use of coherent raman techniques for medical diagnostic and therapeutic purposes, and calibration techniques for same
  • Use of coherent raman techniques for medical diagnostic and therapeutic purposes, and calibration techniques for same

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Embodiment Construction

[0030] An optical, non-invasive, non-destructive system and method is provided to detect molecules, particularly physiological analytes or biomarkers ex vivo, in vivo, or both. In particular, coherent Raman techniques are used for otherwise difficult medical diagnosis and therapeutic procedures.

[0031] In one aspect, a method for optically measuring molecules in a sample, whereby molecular species are identified and quantified by coherent Raman spectroscopy (CARS) is disclosed. Compared to conventional forms of Raman spectroscopy, the CARS technique potentially enhances the molecular signal from a sample by several orders of magnitude while eliminating anharmonic background, reducing measurement time, and enabling real-time analysis. Due to the optical nature of the technology, non-invasive testing is possible.

[0032] In vivo detection of analytes is complicated by the fact that biological tissues scatter or attenuate the light used for measurement, which significantly re...

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Abstract

System and methods are provided to perform non-invasive, real-time, continuous molecular detection and quantification of molecular species in a sample or animal subject using Raman spectroscopy. Such systems and methods may be applied to identify and quantify molecular species found in the body, which may be useful for prenatal diagnosis, detecting deep skin infections, performing cerebral spinal fluid assessment, measuring arterial blood gases, blood glucose, cardiac biomarkers, creatinine flow rates. The non-invasive, quantification of such molecular species continuously in real time enables a significantly more attractive course of therapy than existing protocols.

Description

[0001] Cross References to Related Applications [0002] This application claims U.S. Provisional Patent Application No. 60 / 855,032, filed October 27, 2006, entitled "Use of Coherent Raman Techniques for Medical Diagnostic and Therapeutic Purpose," and filed October 27, 2006, entitled "Method to Calibrate a Non-Invasive Molecular Diagnostic Device," the priority of U.S. Provisional Patent Application No. 60 / 855,033, which is incorporated herein by reference in its entirety. [0003] This application is related to concurrently filed US Patent Application No. (TBA) entitled "Use of Quantum Control Techniques for Medical Diagnostic and Therapeutic Purposes," which is hereby incorporated by reference in its entirety. technical field [0004] The present invention relates to spectroscopic techniques for studying molecules using Raman scattering. Background technique [0005] Raman spectroscopy is a type of spectroscopy that uses the vibrational spectrum of molecules to help char...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00
CPCA61B5/412A61B5/418A61B5/415A61B5/0066A61B5/0075
Inventor I·W·亨特尔S·索马鲁S·拉方丹P·A·安克蒂尔
Owner ARETAIS
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