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External preparation for treating androgens psilosis, seborrheic dermatitis and acne

A technology for seborrheic dermatitis and external preparations, which is applied in the field of preparation of 5α-reductase inhibitor topical solutions, can solve problems such as lack of comprehensive consideration and treatment, and achieve the effect of good viscosity

Inactive Publication Date: 2009-12-09
BEIJING PURUN BIOSCI DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Topical 5α-reductase inhibitors (finasteride) have long been considered ineffective for the treatment of male androgenetic alopecia [1] , the inventor believes that the basic reason lies in the lack of comprehensive consideration and management of the local physiological environment, pathological factors, transdermal absorption and local pharmacokinetics factors

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0031] prescription:

[0032] Finasteride 50mg

[0033] Propylene glycol 50ml

[0034] Benzyl alcohol 5ml

[0035] Isopropyl myristate 5ml

[0036] Thymol 500mg

[0037] Ethanol 840ml

[0038] water 100ml

[0039]

[0040] Makes 1000ml

[0041]Preparation method: weigh finasteride, dissolve in appropriate amount of ethanol, measure propylene glycol and benzyl alcohol, dissolve in appropriate amount of ethanol, measure isopropyl myristate, dissolve in appropriate amount of ethanol, weigh thymol, Dissolve in an appropriate amount of ethanol, add the above four solutions into the batching container, add water, and then add ethanol to 1000ml, shake, shake well, stand still, filter, bottle, and obtain.

example 2

[0043] prescription:

[0044] Finasteride 100mg

[0045] Propylene glycol 50ml

[0046] Benzyl alcohol 5ml

[0047] Isopropyl myristate 5ml

[0048] Thymol 500mg

[0049] Ethanol 840ml

[0050] water 100ml

[0051]

[0052] Makes 1000ml

[0053] Preparation method: weigh finasteride, dissolve in appropriate amount of ethanol, measure propylene glycol and benzyl alcohol, dissolve in appropriate amount of ethanol, measure isopropyl myristate, dissolve in appropriate amount of ethanol, weigh thymol, Dissolve in an appropriate amount of ethanol, add the above four solutions into the batching container, add water, and then add ethanol to 1000ml, shake, shake well, stand still, filter, bottle, and obtain.

example 3

[0055] prescription:

[0056] Finasteride 200mg

[0057] Propylene glycol 50ml

[0058] Benzyl alcohol 5ml

[0059] Isopropyl myristate 5ml

[0060] Thymol 500mg

[0061] Ethanol 840ml

[0062] water 100ml

[0063]

[0064] Makes 1000ml

[0065] Preparation method: weigh finasteride, dissolve in appropriate amount of ethanol, measure propylene glycol and benzyl alcohol, dissolve in appropriate amount of ethanol, measure isopropyl myristate, dissolve in appropriate amount of ethanol, weigh thymol, Dissolve in an appropriate amount of ethanol, add the above four solutions into the batching container, add water, and then add ethanol to 1000ml, shake, shake well, stand still, filter, bottle, and obtain.

[0066] 4. Example 4

[0067] prescription:

[0068] Finasteride 100mg

[0069] Propylene glycol 50ml

[0070] Benzyl alcohol 5ml

[0071] Isopropyl myristate 5ml

[0072] Thymol 500mg

[0073] Ethanol 940ml

[0074] ...

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PUM

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Abstract

The invention provides an external prescription and a preparation process of a 5alpha-reductase inhibitor external preparation for treating androgen spsilosis , seborrheic dermatitis and acne (common comedo). In the prescription and the preparation process, a 5alpha-reductase inhibitor is used as a main medicine and a diluent antiseptic agent, a dissolve-helping moisturizing antiseptic agent, a dissolve-helping disinfecting agent, a softening percutaneous absorption promoter, an antiseptic disinfecting agent, diluent agent, and the like as auxiliary materials, wherein the 5alpha-reductase inhibitor which is originally and orally taken is prepared into an external solution to be directly applied on wounded parts so as to effectively treat the spsilosis, the seborrheic dermatitis and the acne and also reduce side effect caused in such a way that the 5alpha-reductase inhibitor is orally taken to treat the spsilosis. The invention has simple preparation process and good stability.

Description

Technical field [0001] The present invention relates to a preparation method of an external preparation for treating androgenetic alopecia, seborrheic dermatitis and acne, specifically a preparation method of a 5α-reductase inhibitor external solution, which can effectively treat alopecia and seborrheic dermatitis, At the same time as acne, it can reduce the side effects caused by oral administration of 5α-reductase inhibitors in the treatment of hair loss. Background technique [0002] Androgenetic alopecia is the most common type of hair loss in men, also commonly referred to as male pattern baldness, and can occur at the end of puberty. Androgenetic alopecia is a disease related to genetic factors and is very common. It is reported to affect approximately 50% of men and women. It affects about 30 percent of men over the age of 30, and about 65 percent of men between the ages of 21 and 65 experience some degree of baldness or significant hair loss , androgenetic alopeci...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/58A61K8/63A61P17/08A61P17/14A61Q7/00
Inventor (请求不公开姓名)
Owner BEIJING PURUN BIOSCI DEV
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