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Gelatin sponge and preparation method thereof

A technology of gelatin sponge and gelatin, applied in bandages, surgery, absorbent pads, etc., can solve problems affecting the histocompatibility of the final product, and achieve good adhesion and skin tissue regeneration, good structural uniformity, and avoid chemical residues toxic effect

Inactive Publication Date: 2009-11-11
厦门凝赋生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This invention uses formaldehyde as a crosslinking agent. Although there are washing steps, the reagents in the porous material are difficult to remove through simple washing. The problem of formaldehyde residue will inevitably affect the histocompatibility of the final product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Dissolve 30 grams of gelatin in 70 grams of water, heat to 80° C., and stir evenly to obtain a 30% gelatin aqueous solution. Pour the gelatin aqueous solution into a plate, and irradiate 20 kGy with cobalt-60 gamma rays to obtain a gelatin hydrogel with a crosslinking degree of 99%. The hydrogel was soaked in sterile water for 24 hours until the swelling equilibrium, and a water-containing porous material with a water absorption rate of 10 times was obtained. Freeze-dry the aqueous porous material at -80°C, pulverize, sieve and classify with a universal pulverizer at -20°C to obtain a gelatin sponge embolism with uniform pore size and particle size (the average pore size is 15 microns) and soft texture.

Embodiment 2

[0037] Dissolve 12 grams of gelatin and 3 grams of carboxymethyl chitosan in 85 grams of water, heat to 60° C., and stir evenly with a defoaming mixer to obtain an aqueous solution with a solid content of 15%. Pour the aqueous solution into a plate, and irradiate 30 kGy with cobalt-60 gamma rays to obtain a gelatin / carboxymethyl chitosan hydrogel with a crosslinking degree of 82%. Soak the hydrogel in the aqueous solution containing the growth factor for 72 hours until the swelling equilibrium, and obtain a water-containing porous material with a water absorption rate of 20 times. The water-containing porous material is freeze-dried at -40° C. to obtain a gelatin / carboxymethyl chitosan sponge dressing with uniform pore size (the average pore size is 50 microns) and soft texture.

Embodiment 3

[0039] Dissolve 4 grams of gelatin and 6 grams of hydroxypropyl chitosan in 90 grams of water, heat to 60° C., and stir evenly with a defoaming mixer to obtain an aqueous solution with a solid content of 10%. Pour the aqueous solution into a petri dish, and irradiate 10 kGy with cobalt-60 gamma rays to obtain a gelatin / hydroxypropyl chitosan hydrogel with a crosslinking degree of 72%. The hydrogel was soaked in sterile water for 36 hours until the swelling equilibrium, and a water-containing porous material with a water absorption rate of 90 times was obtained. The water-containing porous material is freeze-dried at -40° C. to obtain a gelatin / hydroxypropyl chitosan sponge dressing with uniform pore size (the average pore size is 80 microns) and soft texture.

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Abstract

The invention provides gelatin sponge, gelatin aqueous solution is irradiated to crosslink to form gelatin hydrogel, and then the gelatin hydrogel is swollen, frozen and dried to obtain the gelatin sponge. The invention also provides a preparation method of the gelatin sponge by an irradiation crosslinking way, the whole process flow is finished in a pure water system, the irradiation and crosslinking processes have sterilizing function and good controllability, the obtained product has better structural uniformity compared with a chemical crosslinking method, and the gelatin sponge has unique advantages as biomedical materials.

Description

technical field [0001] The invention relates to a gelatin sponge and a preparation method thereof, in particular to a gelatin sponge prepared by a radiation crosslinking method. Background technique [0002] Gelatin has good biological activity and has a very wide range of uses in the field of biomedicine. Gelatin sponge has a strong hemostatic effect, can quickly absorb a large amount of water and exudate, and can be used as a dressing for surgical incisions, various wounds, and embolisms for various interventional treatments. Modified gelatin sponge with chitosan can further improve the hemostatic speed of the sponge, the ability to absorb exudate, and improve the flexibility of the sponge. [0003] The traditional gelatin sponge or gelatin-chitosan sponge mostly dissolves chitosan with hydrochloric acid and acetic acid, cross-links the gelatin or gelatin / chitosan mixture with formaldehyde, glutaraldehyde and other cross-linking agents, and finally uses freeze-drying meth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/28A61L15/44A61L31/04A61L31/16
Inventor 许零杨超
Owner 厦门凝赋生物科技有限公司
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