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Application of 3'-deoxyadenosine in reducing weight, enhancing insulin sensitivity and improving lipid metabolism

A deoxyadenosine and obesity technology, which is applied in the fields of 3′-deoxyadenosine weight loss, insulin sensitization and lipid metabolism improvement

Active Publication Date: 2009-11-11
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In the prior art, there is no evidence that 3'-deoxyadenosine has the function of preventing and / or treating obesity, insulin resistance, hypercholesterolemia in lipid metabolism disorders, mixed hyperlipidemia, and high and low density lipoprotein metabolism disorders. to report

Method used

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  • Application of 3'-deoxyadenosine in reducing weight, enhancing insulin sensitivity and improving lipid metabolism
  • Application of 3'-deoxyadenosine in reducing weight, enhancing insulin sensitivity and improving lipid metabolism
  • Application of 3'-deoxyadenosine in reducing weight, enhancing insulin sensitivity and improving lipid metabolism

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1: Effect of 3'-deoxyadenosine on weight gain of PF mice

[0040] Materials and Methods

[0041] [Experimental animals] 4-week-old C57BL mice, male, Beijing Weitong Lihua Animal Breeding Center (Animal Qualification Certificate No.SCXK (Beijing). Feeding with high-fat feed, free diet and drinking water. Set up to feed with basal feed at the same time The same batch of mice was used as the normal control group. After continuous feeding for 20 weeks, the animals whose body weight was significantly higher than the normal control group were selected as the obese mouse model (PF).

[0042] [Test product] 3-deoxyadenosine (isolated from the fruiting body of Cordyceps militaris, the purity is above 99.9% after analysis).

[0043] [Feed] Basic feed, containing 12% fat, 62% sugar and 26% protein, with a total calorie of 12.6kJ / g. The homemade high-fat feed contains 60% fat, 26% sugar and 14% protein, with a total calorie of 21.0kJ / g.

[0044] [Positive drug] Fenofibra...

Embodiment 2

[0058] Example 2: Effect of 3'-deoxyadenosine on the insulin sensitivity of IRF mice

[0059] Materials and Methods

[0060] [Experimental animals] 4-week-old C57BL mice, male, Beijing Weitong Lihua Animal Breeding Center (Animal Qualification Certificate No.SCXK (Beijing). Feeding with high-fat feed, free diet and drinking water. Set up to feed with basal feed at the same time The same batch of mice was used as the normal control group. After 20 weeks of continuous feeding, obese mice with obvious insulin resistance in the insulin tolerance test were selected as model animals (IRF).

[0061] [Test product] 3-deoxyadenosine (isolated from the fruiting body of Cordyceps militaris, the purity is above 99.9% after analysis).

[0062] [Feed] Basic feed, containing 12% fat, 62% sugar and 26% protein, with a total calorie of 12.6kJ / g. The homemade high-fat feed contains 60% fat, 26% sugar and 14% protein, with a total calorie of 21.0kJ / g.

[0063] [Positive drug] Fenofibrate is a...

Embodiment 3

[0076] Embodiment 3: 3'-deoxyadenosine is to the influence of oral glucose tolerance (OGTT) of IRF mouse

[0077] Materials and Methods

[0078] [Experimental animals] 4-week-old C57BL mice, male, Beijing Weitong Lihua Animal Breeding Center (Animal Qualification Certificate No.SCXK (Beijing). Feed with high-fat feed, free to eat and drink. Set up to feed with basic feed at the same time The same batch of mice was used as the normal control group. After 20 weeks of continuous feeding, obese mice with obvious insulin resistance in the insulin tolerance test were selected as model animals (IRF).

[0079] [Test product] 3-deoxyadenosine (isolated from the fruiting body of Cordyceps militaris, the purity is above 99.9% after analysis).

[0080] [Feed] Basic feed, containing 12% fat, 62% sugar and 26% protein, with a total calorie of 12.6kJ / g. The homemade high-fat feed contains 60% fat, 26% sugar and 14% protein, with a total calorie of 21.0kJ / g.

[0081] [Positive drug] Fenofibr...

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Abstract

The invention discloses application of 3'-deoxyadenosine in reducing weight, enhancing insulin sensitivity and improving lipid metabolism, and particularly relates to the application of the 3'-deoxyadenosine shown in a formula (1), which is used as a weight reduction pill, an insulin sensitizer and a blood fat regulator, in medicaments and / or health care products, in particular to the application of the 3'-deoxyadenosine in preventing and treating hypercholesterolemia, mixed type hyperlipidemia, and dyslipoproteinemia.

Description

technical field [0001] The present invention relates to the application of 3'-deoxyadenosine in the preparation of medicines and / or health care products for the prevention and / or treatment of obesity, insulin resistance and lipid metabolism disorders, in particular to the application of 3'-deoxyadenosine in the preparation of prevention and / or treatment of hyperlipidemia Application in drugs and / or health products for cholesterolemia, mixed hyperlipidemia and high and low density lipoprotein metabolic disorders. Background technique [0002] Obesity refers to a pathological state of weight gain due to the increase in the number or volume of adipocytes in the body, excessive accumulation or abnormal distribution of fat. The World Health Organization (WHO) clearly recognizes that obesity is the largest chronic disease among adults in the world, and is listed as one of the four major medical and social problems in the world. Obesity is a serious cause of type 2 diabetes, coron...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/29A61K31/7076A61P3/04A61P3/10A61P9/10A61P9/12A61P35/00A61P1/00A61P15/00A61P13/08A61P1/16A61P19/02A61P11/00A61P3/06A61P7/00A61P3/00A23L33/00
Inventor 叶菲朱海波朱平
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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