Method for preparing alginate soft capsule

Abstract

The invention relates to a method for preparing alginate soft capsule. By adopting a mode of emulsifying / de-emulsifying and emulsion dropping, oil-in-water emulsion containing polyvalent metal ions with high oil-water ratio is dropped into univalent soluble alginate solution, and then the polyvalent metal ions react with the univalent alginate solution to form insoluble alginate gel so as to obtain a primary soft capsule form of which outer layer is wrapped with the alginate gel; then, the primary soft capsule form is subjected to steps of drying and dehydrating so that the emulsion inside the soft capsule is de-emulsified; and finally, a circular soft capsule is obtained, wherein the interior of the circular soft capsule has oily liquid substances, the exterior of the circular soft capsule has an alginate gel wrapping layer, the radial size of the circular soft capsule is in millimeter scale, and the circular soft capsule can be directly taken orally. The soft capsule obtained by the method has the advantages of good mechanical property, even and round appearance, non-eccentric oil drops and high oil content; and the preparation method is simple and has low cost. Under the condition that the internal oily liquid substances are the same, the soft capsule which is prepared by the method and can be directly taken orally can be used for replacing gelatin soft capsules which are directly taken orally.

Description

Technical field: [0001] The invention relates to soft capsules, in particular to a method for preparing circular alginate soft capsules whose radial dimension is in the order of millimeters. Background technique: [0002] Soft capsule packaging is a new type of pharmaceutical dosage form developed after tablets, hard capsules, pills, oral liquids and other dosage forms. Soft capsules can quantitatively inject oil or suspensions of oily and powdery functional substances and encapsulate them in the film to form sealed capsules of various sizes and shapes. They have excellent light and oxygen isolation functions and good vision Effect. It is widely welcomed by consumers because of its advantages of masking bad smell, keeping oily substances stable, easy to use, and easy to carry. [0003] At present, most of the round soft capsules with a radial size of millimeters are made by using gelatin as the wrapping wall material and produced by dripping or pressing processes, such as ...

AI Technical Summary

Problems solved by technology

[0004] 1. Gelatin is an animal extract, which is inconvenient for consumers with taboos (such as Muslims or vegetarians). In addition, the occurrence of zoonotic diseases also increases the risk of using animal materials

[0005] 2. The storage conditions of gelatin soft capsules are relatively high. Once the storage temperature, humidity and other conditions exceed the range, the gelatin will melt, age and other quality problems

[0006] 3. The preparation of gelatin soft capsules requires relatively complicated equipment or molds, and it is difficult to greatly increase the output

But the biggest disadvantage of this method is that due to the difference in specific gravity between the inner and outer layer solutions (oil phase and water phase), it is difficult to ensure that the sodium alginate solution formed in the air wraps the droplets of the oil solution and the oil in the soft capsule made of it. Drops are not eccentric, and as the proportion of the contained oil phase increases, the eccentricity will be more serious. The mechanical strength of the obtained alginate soft capsules is low, and the crushing pressure of the heavy object crushing test is less than 0.5 kg. , It is easy to break during transportation, so it is not suitable for the actual production of alginate soft capsules

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