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Method for preparing antibiosis self-expanding material of one-off cervix dilator

A dilator, a disposable technology, applied in dilators, medical science, surgery, etc., can solve the problems of lack of antibacterial and anti-inflammatory effects, strength decline, fracture, etc., to reduce the difficulty of surgery, reduce complications, and good water absorption and swelling Effect

Active Publication Date: 2009-10-28
DONGGUAN KEWEI MEDICAL INSTR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these self-expanding medical polymer materials still have some shortcomings, such as seaweed expansion rods and gelatin expansion rods, after absorbing body fluids in the cervix, their strength will decrease, and they may break and break when they are taken out
Furthermore, the existing self-expanding materials lack antibacterial and anti-inflammatory effects, because some conditional pathogenic bacteria often exist in the cervical canal of normal women, and the endocervical tissue of many patients often has inflammation or surgery. injury, so it is important to prevent infection during cervical dilation surgery

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) 4.0g polyvinyl alcohol and 0.4g chitosan (deacetylation degree 90%, molecular weight 20000) were heated and dissolved in 80mL of dilute acetic acid, cooled to room temperature to obtain polyvinyl alcohol / chitosan mixed solution;

[0021] (2) Add 20 mL of 0.32 mol / L glutaraldehyde solution to the polyvinyl alcohol-chitosan mixed solution prepared in step (1), fully stir, react for 1 hour at 60° C., and stand at room temperature for 24 hours to obtain Cross-linked polyvinyl alcohol-chitosan composite gel.

[0022] (3) The obtained polyvinyl alcohol-chitosan composite gel is fully washed with water, freeze-dried, and then molded to obtain a polyvinyl alcohol-chitosan compressed sponge rod. After the compressed sponge rod is expanded by 300% in water absorption diameter, the tensile strength is 1.8MPa, and the antibacterial rate to Staphylococcus aureus ATCC6538 is 90.4%, which has a strong antibacterial effect and can be used as an antibacterial self-acting agent for d...

Embodiment 2

[0024] (1) 10.0 g of polyvinyl alcohol and 2.0 g of chitosan (degree of deacetylation 100%, molecular weight 5000) were heated and dissolved in 80 mL of dilute acetic acid, and cooled to room temperature to obtain a polyvinyl alcohol-chitosan mixed solution;

[0025] (2) Add 20 mL of 0.43 mol / L glutaraldehyde solution to the polyvinyl alcohol-chitosan mixed solution prepared in step (1), stir fully, react for 1 hour at 50° C., and leave it at room temperature for 24 hours to obtain Cross-linked polyvinyl alcohol-chitosan composite gel.

[0026] (3) The obtained polyvinyl alcohol-chitosan composite gel is fully washed with water, freeze-dried, and then molded to obtain a polyvinyl alcohol-chitosan compressed sponge rod. After the compressed sponge rod is expanded by 300% in water absorption diameter, the tensile strength is 2.1MPa, and the antibacterial rate to Staphylococcus aureus ATCC6538 is 92.1%, which has a strong antibacterial effect and can be used as an antibacterial s...

Embodiment 3

[0028] (1) 10.0g polyvinyl alcohol and 0.5g sulfated chitosan are heated and dissolved in 80mL of water, cooled to room temperature to obtain polyvinyl alcohol-sulfated chitosan mixed solution;

[0029] (2) Add 20 mL of 0.43 mol / L formaldehyde solution to the polyvinyl alcohol-sulfated chitosan mixed solution prepared in step (1), fully stir, react for 2 hours at 50° C., and stand at room temperature for 24 hours to obtain Cross-linked polyvinyl alcohol-sulfated chitosan composite gel.

[0030] (3) The obtained polyvinyl alcohol-sulfated chitosan composite gel is fully washed with water, freeze-dried, and then molded to obtain a polyvinyl alcohol-sulfated chitosan compressed sponge rod. After the compressed sponge rod is expanded by 300% in water absorption diameter, the tensile strength is 2.2MPa, and the antibacterial rate to Staphylococcus aureus ATCC6538 is 91.4%, which has a strong antibacterial effect and can be used as an antibacterial self-protection device for disposa...

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Abstract

The invention relates to a method for preparing an antibiosis self-expanding material of a one-off cervix dilator. The method comprises the steps of: mixing chitosan or chitosan derivative with polyvinyl alcohol solution; carrying out cross-linking to form compound gel; and carrying out washing, drying, mould-pressing and shaping to obtain polyvinyl alcohol-chitosan or polyvinyl alcohol-chitosan derivative compound compressed sponge which has not only excellent water-absorbing expandability, wet mechanical strength and biological compatibility but also antibiosis and inflammation-diminishing effects. The polyvinyl alcohol- chitosan or polyvinyl alcohol-chitosan derivative compound compressed sponge can be used for preparing antibiosis one-off cervix dilator and can alleviate pain of patients in operation as well as reduce operation difficulty and occurrence of operation complicating diseases.

Description

technical field [0001] The invention relates to the field of medical polymer materials, in particular to a preparation method of an antibacterial self-expanding material used for a disposable cervical dilator. Background technique [0002] Cervical dilator is a medical and surgical instrument commonly used in obstetrics, gynecology and family planning. On the one hand, induced abortion or induction of labor performed in order to reduce complications caused by certain high-risk pregnancy and reduce perinatal mortality requires effective softening and expansion of cervical connective tissue; on the other hand, as a minimally invasive gynecological Diagnosis and treatment techniques, hysteroscopic surgery and various operations mediated by it have no incision, less trauma, preserve the uterus, do not affect ovarian endocrine function, preserve the quality of life, have no complications of laparotomy, and have a short hospital stay. The advantages of fast recovery and good surg...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/16A61M29/04C08J9/28
Inventor 曾戎唐云华
Owner DONGGUAN KEWEI MEDICAL INSTR
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