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United autonomous respiration control on-line alignment technique using iodized oil image to guide image-guided radiotherapy

A spontaneous breathing, image-guided technology, applied in radiation therapy, treatment, etc., can solve the problems of unclear display, inability to overcome scattering, existence of artifacts, etc., to achieve good clinical efficacy, improve treatment effect, and reduce damage.

Inactive Publication Date: 2009-10-21
SHANDONG RES INST OF TUMOUR PREVENTION TREATMENT
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Problems solved by technology

Cone beam CT scanning is hereinafter referred to as CBCT. The imaging principle of KV-CBCT itself and the insurmountable scattering make the imaging of KV-CBCT worse than that of spiral CT, and there are artifacts. Application bottlenecks in the process of radiotherapy for liver tumors

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  • United autonomous respiration control on-line alignment technique using iodized oil image to guide image-guided radiotherapy
  • United autonomous respiration control on-line alignment technique using iodized oil image to guide image-guided radiotherapy
  • United autonomous respiration control on-line alignment technique using iodized oil image to guide image-guided radiotherapy

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Embodiment

[0048] From image 3 It can be seen from the figure that the upper right is the planned CT image, and the remaining three are the horizontal, coronal, and sagittal CBCT images. Although the CBCT images are not clear and have artifacts, the lipiodol images on the CBCT images are clearly displayed. Feasibility of lipiodol image as registration reference:

[0049] (1) Lipiodol retention time:

[0050] Lipiodol cannot be cleared due to the lack of lymphatic system in liver tumor tissue and poor clearance function. Literature research shows that lipiodol selectively accumulates and persists in the post-tumor necrosis area, which generally persists for 2-6 months or even longer; Although the oil can selectively accumulate, the site where it gradually disappears is the survival area behind the tumor thrombus, which usually disappears in 1-2 months, and a small amount of lipiodol usually disappears in 2 weeks in the non-cancerous liver parenchyma.

[0051] The technical research gro...

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Abstract

The invention provides a united autonomous breath control on-line alignment technique using iodized oil image to guide image-guided radiotherapy, wherein, the autonomous breath control technique (ABC) is employed to control the liver to move with the breath in the process of radiation treatment, meanwhile, the iodized oil image is employed to carry out 3-D-registration-based image-guided on-line alignment positioning errors between a planned CT and a conical beam CT (CBCT); in addition, strengths of both aspects are combined to maximize accuracy in the radiation treatment in the liver cancer, thus overcoming the defect of depending on the musculus diaphragm, the vertebral body and the liver to conduct 2-D registration to indirectly reflect movement of liver neoplasm and providing a novel radiation treatment technology with high accuracy which can improve radiation treatment dosage for liver neoplasm while reducing harm caused by normal liver organization radiation treatment for liver cancer patients who are not suitable for operations.

Description

technical field [0001] The invention relates to a technology for precise treatment of liver tumors by image-guided radiotherapy using lipiodol images, in particular to an online correction technology for image-guided radiotherapy combined with spontaneous breathing control by relying on lipiodol images. Background technique [0002] Hepatocellular carcinoma (HCC) is a common tumor in my country. Only 20% to 30% of patients diagnosed with HCC can receive radical treatment such as surgical resection or liver transplantation in the early stage. In recent years, radiotherapy, especially three-dimensional conformal radiotherapy (3DCRT) has played an increasingly important role in the treatment of unresectable HCC patients. Since the radiotherapy dose of liver tumors is a key factor affecting the survival of patients, how to increase the radiotherapy dose of liver tumors while reducing the radiotherapy damage to normal liver tissues has become an urgent problem to be solved. [0...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N5/00
Inventor 于金明岳金波尹勇孙新东卢洁刘同海朱健余宁莎齐亮
Owner SHANDONG RES INST OF TUMOUR PREVENTION TREATMENT
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