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Extracting method for improving content of bilobalide in folium ginkgo extract

A technology of Ginkgo biloba extract and ginkgo lactone is applied in the directions of medical raw materials derived from Ginkgo biloba, drug combinations, nervous system diseases, etc. Problems such as low lactone content

Active Publication Date: 2011-09-07
SHANGHAI SINE PROMOD PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Because bilobalide has higher requirements on the pH value, and in the step of washing with 15% hydrochloric acid during the first adsorption and elution, the above method does not regulate the pH value, which will affect the pH value of bilobalide. As a result of the content, that is, bilobalide cannot be eluted well during the first adsorption and elution process of washing with 15% hydrochloric acid, resulting in too low bilobalide content

Method used

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  • Extracting method for improving content of bilobalide in folium ginkgo extract
  • Extracting method for improving content of bilobalide in folium ginkgo extract
  • Extracting method for improving content of bilobalide in folium ginkgo extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0131] (1) Processing of Ginkgo biloba

[0132] Grind 50g ginkgo leaves into 1CM with a pulverizer 2 sized pieces of ginkgo biloba,

[0133] (2) Extraction

[0134] ① Add 250ml of 90% alcohol, it is advisable to submerge the leaves, soak overnight;

[0135] ②Heat to 70°C in the morning of the next day, reflux and extract for 3 hours, and obtain 126ml of the first extract;

[0136] ③ Add 150ml of drinking water and heat to 70°C, reflux extraction for 2 hours to obtain 95ml of the second extract,

[0137] ④ Add 50ml of drinking water to rinse the leaf residue to obtain 46ml of water;

[0138] (3) Concentration under reduced pressure

[0139] Combine the above extracts and water, and concentrate under reduced pressure until there is no alcohol smell. The vacuum degree of concentration is -0.085Mpa, the equilibrium temperature is 55°C, and 75ml of concentrated solution is obtained;

[0140] (4) Water sinking

[0141]① Add 75ml of the obtained concentrated solution to 120ml ...

Embodiment 2

[0164] According to the method of Example 1, the difference is that the pH value of 15% ethanol is adjusted to 6.5 (the original pH value of 15% hydrochloric acid used is 4.73, and 15% is adjusted with 1 mol / liter of hydrochloric acid) pH of ethanol), described resin post is DA201 resin post.

[0165] According to the 2005 edition of the Pharmacopoeia of the People's Republic of China, the contained bilobalide content is 1.4%.

Embodiment 3

[0167] According to the method of Example 1, the difference is that the pH value of 15% ethanol is adjusted to 7.0 (the original pH value of 15% hydrochloric acid used is 4.73, and 15% is adjusted with 1 mol / liter of hydrochloric acid) pH of ethanol)

[0168] According to the 2005 edition of the Pharmacopoeia of the People's Republic of China, the contained bilobalide content is 1.4%.

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Abstract

The invention provides an extracting method for improving the content of bilobalide in a folium ginkgo extract. In the first absorption and elution process of extracting folium ginkgo, ethanol with the range of pH value regulated by 1mol / l of hydrochloric acid being between 6.0 and 7.5 is used for washing the folium ginkgo, thereby obviously increasing the content of the bilobalide. The method issimple and easy and is suitable to industrialized production.

Description

Technical field: [0001] The invention relates to traditional Chinese medicine, in particular to an extraction method for increasing the content of bilobalide in ginkgo extract. Background technique: [0002] Ginkgo biloba has a variety of pharmacological effects. Ginkgo biloba mainly contains flavonol glycosides, terpenoid lactones, phenols, amino acids and other chemical components. Ginkgo biloba extract is a preparation made by separating and enriching the active ingredients of Ginkgo biloba. Ginkgo biloba extract has the effects of improving cardiovascular and cerebrovascular circulation, protecting the liver, anti-inflammation, anti-allergy, and improving the immune function of the body. Due to its remarkable curative effect and low side effects, it has become a best-selling product for treating senile diseases in Europe, America and all over the world. [0003] In recent years, studies have found that Ginkgo biloba extract has definite curative effect on the treatment ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/16A61P25/28
Inventor 胡林森谢跃进
Owner SHANGHAI SINE PROMOD PHARMA
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