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Extracting method for improving content of bilobalide in folium ginkgo extract

A technology of Ginkgo biloba extract and bilobalide, which is applied in the direction of medical raw materials derived from Ginkgo biloba, drug combinations, nervous system diseases, etc., can solve the problem of affecting the content of bilobalide, the content of bilobalide is low, and bilobalide cannot be easily treated good elution etc.

Active Publication Date: 2009-10-21
SHANGHAI SINE PROMOD PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Because bilobalide has higher requirements on the pH value, and in the step of washing with 15% hydrochloric acid during the first adsorption and elution, the above method does not regulate the pH value, which will affect the pH value of bilobalide. As a result of the content, that is, bilobalide cannot be eluted well during the first adsorption and elution process of washing with 15% hydrochloric acid, resulting in too low bilobalide content

Method used

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  • Extracting method for improving content of bilobalide in folium ginkgo extract
  • Extracting method for improving content of bilobalide in folium ginkgo extract
  • Extracting method for improving content of bilobalide in folium ginkgo extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0130] (1) Treatment of Ginkgo biloba leaves

[0131] Crush 50g ginkgo biloba leaves into 1CM with a grinder 2 Small pieces of ginkgo leaf,

[0132] (2) Extraction

[0133] ①Add 250ml of 90% alcohol, it is advisable to soak the leaves, soak overnight;

[0134] ② Heat to 70°C the next morning, reflux and extract for 3 hours to obtain 126ml of the first extract;

[0135] ③Add 150ml of drinking water and heat it to 70°C, reflux and extract for 2 hours to obtain 95ml of the second extract.

[0136] ④ Add 50ml of drinking water to rinse the leaf residue to obtain 46ml of water;

[0137] (3) Concentration under reduced pressure

[0138] Combine the above extract and water, and concentrate under reduced pressure until there is no alcohol taste. The vacuum degree of the concentration is -0.085Mpa, and the equilibrium temperature is 55°C to obtain 75ml of concentrate;

[0139] (4) Water sink

[0140] ① Add 75ml of the obtained concentrated solution to 120ml of 35℃ hot water to dilute, and ...

Embodiment 2

[0163] According to the method of Example 1, the difference is that the acid alkalinity value of 15% during the first adsorption and elution is adjusted to 6.5 (the original acid alkalinity of the 15% hydrochloric acid used is 4.73, and 15% is adjusted with 1 mol / L hydrochloric acid. The acidity and alkalinity of ethanol), the resin column is DA201 resin column.

[0164] According to the 2005 edition of the Pharmacopoeia of the People’s Republic of China, the content of bilobalide is 1.4%.

Embodiment 3

[0166] According to the method of Example 1, the difference is that the acid alkalinity value of 15% during the first adsorption and elution is adjusted to 7.0 (the original acid alkalinity of 15% hydrochloric acid used is 4.73, and 15% is adjusted with 1 mol / L hydrochloric acid. (PH of ethanol)

[0167] According to the 2005 edition of the Pharmacopoeia of the People’s Republic of China, the content of bilobalide is 1.4%.

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Abstract

The invention provides an extracting method for improving the content of bilobalide in a folium ginkgo extract. In the first absorption and elution process of extracting folium ginkgo, ethanol with the range of pH value regulated by 1mol / l of hydrochloric acid being between 6.0 and 7.5 is used for washing the folium ginkgo, thereby obviously increasing the content of the bilobalide. The method is simple and easy and is suitable to industrialized production.

Description

Technical field: [0001] The invention relates to traditional Chinese medicine, in particular to an extraction method for increasing the content of bilobalide in Ginkgo biloba extract. Background technique: [0002] Ginkgo biloba has a variety of pharmacological effects. Ginkgo biloba mainly contains flavonol glycosides, terpenoid lactones, phenols, amino acids and other chemical components. Ginkgo biloba extract is a preparation made by separating and enriching the effective ingredients of ginkgo biloba. Ginkgo biloba extract has the effects of improving cardiovascular and cerebrovascular circulation, protecting the liver, anti-inflammatory, anti-allergic, and improving the immune function of the body. Due to its remarkable curative effect and low side effects, it has become a best-selling product for the treatment of senile diseases in Europe, America and around the world. [0003] In recent years, studies have found that Ginkgo biloba extract has a definite effect on the treatm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61P25/28
Inventor 胡林森谢跃进
Owner SHANGHAI SINE PROMOD PHARMA
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