Drug release tubular support provided with internal supporting wings

Abstract

The invention relates to a drug release tubular support provided with internal supporting wings, which comprises a naked support, a first drug release layer and a second drug release layer, wherein the naked support comprises a central hole, a central shaft, supporting wings and a peripheral tube body; the central shaft is positioned in the center of the support; the central hole is positioned inside the central shaft; the supporting wings are radially distributed on the periphery of the central shaft; and the supporting wings are connected with the central shaft and the peripheral tube body and are separated from each other to form a plurality of sectorial cavities. The cavity fluid can flow freely in the sectorial cavities in the support; the first drug release layer is arranged on the surface of the sectorial cavities in the naked support, and drugs carried by the first drug release layer can be eluted by the fluid flowing across the cavities of the support and move and are distributed along with the fluid, so that the drug release tubular support has the function of treating the whole body; and the second drug release layer is coated on the surface of the peripheral tube body of the naked support and directly contacts with the inner wall of the human cavities, so that the drug release tubular support has the function of local drug release. The drug release tubular support can effectively resist stenosis or obstruction of blood vessels or cavities and the development of stenosis or obstruction.

Description

technical field [0001] The invention relates to a component in the technical field of medicine and medical equipment, in particular to a drug-releasing tubular stent with inner support wings. Background technique [0002] Benign and malignant stenosis or obstruction of blood vessels and digestive tract are common and serious diseases in clinical practice. In addition to surgical resection, radiotherapy and chemotherapy, commonly used interventional methods mainly include balloon dilatation (mainly for benign strictures) and stent placement. Among them, stent placement is a very important palliative treatment method, which can effectively improve the quality of life of patients and prolong survival time. [0003] However, traditional metal stents, covered stents and drug-eluting stents still have at least the following disadvantages: (1) only relying on the deformation recovery mechanical force of the tube wall to support narrow or obstructed blood vessels or digestive tract...

AI Technical Summary

Problems solved by technology

[0003] However, traditional metal stents, covered stents and drug-eluting stents still have at least the following disadvantages: (1) only relying on the deformation recovery mechanical force of the tube wall to support narrow or obstructed blood vessels or digestive tract lumens cannot provide ideal Mechanical support, when the stenosis or obstruction continues to develop, the closure of the stent is likely to occur, resulting in restenosis of the blood vessel or lumen; (2) It only plays a palliative role in mechanical support and short-term relief, and does not have a real local treatment (3) The traditional braided bare stent cannot solve the problem of blood vessel or lumen perforation, which may lead to leakage of blood or lumen fluid. To some extent, it can prevent the inward growth of the tumor through the mesh of the stent, but it still cannot prevent the longitudinal overgrowth and compressive restenosis of the tumor; (4) After the stent is implanted, it still needs to cooperate with systemic drug therapy, but the blood of cancer tissue administered systemically The concentration of the drug is low, and it is difficult to achieve an effective therapeutic concentration; if the therapeutic effect is to be achieved, long-term administration of large doses is necessary, but most anticancer drugs have serious side effects. It is not advisable for patients; (5) The drug release of the currently reported drug-eluting stents is mostly for the purpose of single treatment, and multiple drug release programs cannot be carried out at the same time, which is not conducive to the comprehensive treatment of diseases

Its shortcoming is that the stent is a metal mesh ring stent, which cannot treat the disease of pipeline perforation; in addition, the tubular stent composed of mesh rings does not have an inner support, and cannot resist the occurrence of restenosis well; Covered in the small holes and slits of the metal mesh ring, it is impossible to achieve a large area of ​​contact between the drug and the lesion, so that its therapeutic effect is limited

Its disadvantage is that the scaffold is a tubular polymer scaffold formed by extrusion or braiding, with mesh holes, which is not conducive to the treatment of pipeline perforation; in addition, the polymer scaffold does not have a supporting skeleton and cannot be well Resistance to restenosis; the stent is not designed to release drugs, so it can only be used for palliative treatment or must be combined with other forms of drug treatment

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