Application of chroman compound HEF-19 in preparing intestinal canal smooth muscle antispastic and antidiarrhoeal
A technology of HEF-19 and compounds, applied in the field of medicine
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Embodiment 1
[0017] 1. Experimental materials
[0018] animal:
[0019] New Zealand rabbits, both male and female, weighing 2.0-2.5kg, provided by the Experimental Animal Center of Shenyang Pharmaceutical University, certificate number: Liaoshidongzi No. 033.
[0020] Hef-19: Purity>99%, provided by Organic Laboratory of Shenyang Pharmaceutical University.
[0021] 2. Experimental method
[0022] 1. Effect of HEF-19 on spontaneous activity of isolated small intestine of rabbits
[0023] After the tension of the specimen was stabilized, HEF-19 with different final concentrations (10 -6 mol / L, 10 -5 mol / L, 10 -4 mol / L) 0.1ml and solvent water, observe and record the change of small intestine autonomic contraction under each concentration, and record the change of tension and amplitude before and after administration. Taking the tension or amplitude before administration as 100%, the percentage of small intestine tension or amplitude after administration was calculated. The experimenta...
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