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Pine pollen and cyclodextrin composition, method for preparing same, use of same in preparation of health-care products for resisting fatigue and improving immunity of organisms

A technology of cyclodextrin and pine pollen, which is applied in the directions of drug combination, inactive medical preparations, antidote, etc., can solve the problem of poor elastic formability of fibrous particles, low product dissolution and dispersion performance, and easy deterioration of raw materials and preparations. Deterioration and other problems, to achieve the effect of fine and uniform particle size, improve immunity, eliminate oxidation and bacterial infection

Inactive Publication Date: 2009-09-02
NANJING NORMAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, pine pollen has a tough cell wall (composed of sporopollenin, pectin and cellulose, etc.), of which sporopollenin (C 98 h 22 o 24 ) has acid resistance, alkali resistance, temperature resistance and pressure resistance, and stable physical and chemical properties to gastric acid and other digestive system enzymes. After the wall is broken, it is beneficial for the human body to absorb the active ingredients. Protection, easy to oxidize, easy to infect bacteria and cause qualitative change, a little improper storage will produce odor, resulting in serious excess of peroxide value and acid value, resulting in easy deterioration of raw materials and preparations
In addition, broken wall pine pollen has high viscosity, poor fluidity, and fibrous particles have a certain degree of poor elastic formability, making it difficult to press into tablets, which increases the difficulty of preparation, and the dissolution and dispersion performance of the product is not high.

Method used

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  • Pine pollen and cyclodextrin composition, method for preparing same, use of same in preparation of health-care products for resisting fatigue and improving immunity of organisms
  • Pine pollen and cyclodextrin composition, method for preparing same, use of same in preparation of health-care products for resisting fatigue and improving immunity of organisms
  • Pine pollen and cyclodextrin composition, method for preparing same, use of same in preparation of health-care products for resisting fatigue and improving immunity of organisms

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Example 1, mix 450 grams of broken wall pine pollen with 450 grams of β-cyclodextrin, add 2000 milliliters of water and mix evenly, stir and grind for 2 hours, then dry under reduced pressure at 50°C for 10 hours, pulverize, and pass through a 100-mesh sieve to obtain About 900 grams of powdery solid clathrate.

[0055] Gained solid clathrate adds auxiliary material (10% of prescription total amount): 40 grams of microcrystalline cellulose, 45 grams of sodium starch glycolate, 5 grams of citric acid, 10 grams of fructose; The clathrate was thoroughly mixed, dry granulated, and then compressed into tablets to obtain 1000 pine pollen chewable tablets (1000 mg / tablet, broken wall pine pollen content: 450 mg / tablet).

Embodiment 2

[0056] Example 2, mix 500 grams of broken wall pine pollen with 300 grams of β-cyclodextrin, add 2000 milliliters of water and mix evenly, stir and grind for 2 hours, then dry under reduced pressure at 50°C for 10 hours, pulverize, and pass through a 100-mesh sieve to obtain About 800 grams of powdery solid clathrate.

[0057] The obtained solid clathrate was added with the following auxiliary materials: 20 grams of microcrystalline cellulose, 40 grams of starch, 35 grams of sodium starch glycolate, and 5 grams of magnesium stearate; after the various auxiliary materials were fully mixed, take 2 / 3 of the auxiliary materials and solid Mix the clathrate, mix thoroughly, moisten the soft material with 70% ethanol, pass through a 14-mesh sieve to granulate, dry at 50°C for 2 hours, add another 1 / 3 amount of auxiliary materials after granulation, mix well and then compress into tablets Get 2000 pine pollen sheet products (broken pine pollen content: 250 mg / sheet).

Embodiment 3

[0058] Example 3, 500 grams of broken pine pollen was soaked in 10 liters of 95% ethanol for 10 hours, percolated with 95% ethanol, and about 10 liters of 95% ethanol was added until the percolation liquid was almost colorless, and the percolation liquid was combined. Concentrate and recover ethanol below 40°C until there is no alcohol smell, and obtain about 102 grams of yellow syrupy extract. Mix the extract with 400 grams of cyclodextrin, add 400 milliliters of water, stir and grind for 1 hour. After the system becomes a viscous paste, dry it under reduced pressure at 50°C and pass through a 100-mesh sieve to obtain a light yellow solid package of pine pollen extract. Compound about 500 grams.

[0059] Add auxiliary materials to the obtained solid clathrate: 55 grams of microcrystalline cellulose, 40 grams of sodium starch glycolate, 2 grams of citric acid, 1 gram of fructose, and 2 grams of magnesium stearate; The mixture was fully mixed, dry granulated, and compressed in...

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Abstract

The invention disclose a pine pollen and cyclodextrin composition, a method for preparing the same and application of the same in the preparation of health-care products for resisting fatigue and improving immunity of organisms. The composition consists of extract of wall-broken pine pollen and cyclodextrin, and is characterized in that the mass ratio of the pine pollen or the extract of the pine pollen to the cyclodextrin is 1:0.6-5. The preparation method comprises the following steps of: adding pure water and the cyclodextrin into to the wall-broken pine pollen or the extract of the wall-broken pine pollen in an amount which are two times of that of the wall-broken pine pollen or the extract of the wall-broken pine pollen; uniformly stirring the mixture and grinding the mixture for 0.5 to 3 hours; drying the ground mixture under reduced pressure at a temperature below 50 DEG C; and crushing the mixture and passing the crushed mixture through a sieve to obtain the pine pollen and cyclodextrin composition. The application of the pine pollen and cyclodextrin composition in the preparation of the health-care products for resisting the fatigue and improving the immunity of the organisms has the advantages that: the composition is strong in stability; the preparations have good performance; the stability of active ingredients is obviously improved compared with the wall-broken pine pollen on the market; the products are long in storage time and convenient in transport; and the active ingredients of pine pollen can be absorbed by human bodies.

Description

technical field [0001] The invention relates to a composition of pine pollen and cyclodextrin, its preparation method and its application in the preparation of anti-fatigue and immunity-improving health care products. Background technique [0002] Pine pollen is the dried pollen of Pinus massoniana Lamb., Pinus tabulaeformis Carr. or the same tree species. It is also known as pine yellow. The function of pine pollen is understood: "Pine yellow, the smell is sweet and flat and non-toxic, it is mainly used to cure cold and heat evil spirits in trusted subordinates, facilitate urination, eliminate blood stasis, take a long time to lighten the body, benefit energy, and prolong life." "Compendium of Materia Medica" is recorded as: Songhua, sweet, Warm and non-toxic. Run the heart and lungs, benefit qi, etc. Pine pollen has been used both as medicine and food for more than a thousand years. The Pharmacopoeia of the People's Republic of China stipulates the sensory indicators, mo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/15A61K47/48A61P37/04A61P39/00A61K47/69
Inventor 任勇吴玲裴会娜安翠翠
Owner NANJING NORMAL UNIVERSITY
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