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Use of total saponin extract of fenugreek

A technology of total saponins and fenugreek, applied in the application field of fenugreek total saponins extract, can solve problems affecting the physical and mental health of the elderly, reducing the quality of life, androgen deficiency, etc.

Active Publication Date: 2009-08-05
GENEHAM PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At the same time, the lower testosterone level in the body can lead to partial androgen deficiency syndrome (PADAM) in middle-aged and elderly men, which seriously affects the physical and mental health of the elderly and reduces the quality of life.

Method used

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  • Use of total saponin extract of fenugreek
  • Use of total saponin extract of fenugreek
  • Use of total saponin extract of fenugreek

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Take 10 kilograms of fenugreek, add 120 kilograms of 50% ethanol, reflux extraction 3 times, each time is 1 hour, centrifuge, combine the centrifugate, concentrate, and obtain a concentrated solution; the concentrated solution is adsorbed on a D101 macroporous resin column, washed with water and discarded , washed with 0.05% NaOH solution, eluted with 80% ethanol, collected the eluate, concentrated in vacuo to a thick paste, and dried in vacuo to obtain the total fenugreek saponin extract, calculated as diosgenin, with a saponin content of 35.7%. This extract is used in Examples 2-5.

[0023] The method for extracting total saponins in this example refers to "Technology Research on Extraction and Purification of Total Saponins from Fenugreek with Macroporous Adsorption Resin" [J]. Chinese Medicine Research and Information, 2005, 7(6): 19-21.

Embodiment 2

[0025] Acute Toxicity Test of Fenugreek Total Saponins Extract

[0026] 1 Experimental materials

[0027] 1.1 Drugs: Fenugreek total saponins powder, take 15g of this product powder, add water to 100ml, make 1ml suspension containing 0.15g extract, this concentration is the maximum concentration.

[0028] 1.2 Animals: clean-grade Kunming mice, 60 males, weighing 18-22 g, provided by Dongchuang Experimental Animal Science and Technology Service Department, Kaifu District, Changsha City, experimental animal production license: SCXK (Xiang) 2006-0001; Provided by the Animal Room of Hunan Provincial Institute for Drug Control, Experimental Animal Use License: SYXK (Xiang) No. 2003-0006. The temperature in the laboratory was 18-25°C. The animals were reared in separate cages, 5 in each cage, fed with standard pellet feed, and free to ingest food and water.

[0029] 2 Experimental methods and results

[0030] 2.1 Preliminary test Take 20 mice (male), weighing 18-22g. One-time in...

Embodiment 3

[0038] Effects of Fenugreek Total Saponins Extract on Body Weight and Serum Testosterone in Rats

[0039] 1 Experimental materials

[0040] Reagent: total fenugreek saponins powder of the present invention, the powder is dissolved in distilled water during the experiment. Animals: clean grade Kunming SD rats, provided by Dongchuang Experimental Animal Science and Technology Service Department, Kaifu District, Changsha City; experimental animal production license: SCXK (Xiang) No. 2006-0001; animal room of Hunan Provincial Drug Control Institute, experimental animals License: SYXK (Xiang) No. 2003-0006. Adaptive feeding was carried out for 3 days before the experiment, and 5 clean-grade Kunming SD rats were fed per cage.

[0041] 2 Experimental methods and results

[0042] 2.1 Drug preparation method and experimental animal grouping

[0043] The experimental animals are generally divided into four groups: the first group is the normal control group, which is given equal vol...

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Abstract

The invention provides application of a common fenugreek seed total saponin extract in preparing a medicine or a health care product for treating or preventing the reduction of the testosterone level and the exercise tolerance. The usage and the dosage of the medicine are determined according to the illness state of patients; the medicine can be taken for 2 to 3 times per day; and the daily dosage per person is between 200 and 4,000 milligrams and preferably between 600 and 1,200 milligrams or is between 0.0036 and 0.0145 gram per kilogram of the body weight. Common fenugreek seed total saponin can improve the testosterone level of blood serum, so that the common fenugreek seed total saponin extract has important function of treating or preventing the reduction of the testosterone level and the exercise tolerance.

Description

technical field [0001] The invention relates to a new application of a traditional Chinese medicine fenugreek total saponins extract, in particular to an application of a fenugreek total saponins extract in medicine or health care products for treating or preventing testosterone level decrease and exercise tolerance decrease. Background technique [0002] Testosterone is the main component of androgen, which belongs to C-19 steroid hormone, and is mainly synthesized in Leydig cells of testis. In addition to producing and maintaining male reproductive organs, reproductive functions and secondary sexual characteristics, testosterone has been found in recent years. Low can cause many diseases and reduced exercise tolerance: [0003] Plasma testosterone in male patients with coronary heart disease was significantly lower than that in normal subjects. Intervention studies on coronary heart disease patients with decreased androgen levels also found that long-term intervention tre...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61P5/26A61P43/00A61K131/00
Inventor 谭华
Owner GENEHAM PHARMA CO LTD
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