Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for synthesizing N,N-diethylamino ethanethiol

A technology of diethylaminoethanethiol and ethylaminoethanethiol, which is applied in the field of N, can solve the problems of high recovery energy consumption, low yield, poor product quality, etc., achieve environmental protection, high yield, and prevent self-polymerization Effect

Active Publication Date: 2009-07-15
河北远大九孚生物科技有限公司
View PDF0 Cites 12 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0020] In this method, N, N diethylaminoethanethiol is synthesized by pressurized reaction with ethylene thiolane and diethylamine, and needs to be reacted in an organic solvent. The amount of solvent used is large, and the recovery energy consumption is large, and it is difficult to avoid The alkane itself polymerizes into a white solid, which eventually leads to poor product quality and low yield

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for synthesizing N,N-diethylamino ethanethiol
  • Method for synthesizing N,N-diethylamino ethanethiol
  • Method for synthesizing N,N-diethylamino ethanethiol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] In a 500-liter reactor, 60 kilograms of ethylene sulfide were first added and stirred, then 180 kilograms of diethylamine were added, and 2 kilograms of petroleum ether were added, followed by stirring, and the temperature was refluxed at 60°C. After the reaction was completed for 10 hours, diethylamine and petroleum ether were recovered by distillation, and then 107 kg of N,N-diethylaminoethanethiol was obtained by distillation under reduced pressure.

[0042] The reaction equation of the present embodiment is:

[0043]

[0044] The mass percentage concentration of N,N-diethylaminoethanethiol in this embodiment is 99%, and the yield can reach 95.5%.

Embodiment 2

[0046] In a 2000-liter reactor, 240 kilograms of ethylene sulfide were first added and stirred, then 1200 kilograms of diethylamine were added, and 4 kilograms of sodium borohydride were added, followed by stirring and heating at 55°C. Reflux reaction for 15 hours, after the reaction is completed, diethylamine and sodium borohydride are recovered by distillation, and then 435 kg of N,N diethylaminoethanethiol can be obtained by distillation under reduced pressure.

[0047] The mass percentage concentration of N,N diethylaminoethanethiol in this embodiment is 99%, and the yield can reach 96.4%.

[0048] The reaction equation of the present embodiment is:

[0049]

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
boiling pointaaaaaaaaaa
Login to View More

Abstract

The invention relates to a synthetic method for N, N-diethylaminoethanethiol, comprising the following step: the N, N-diethylaminoethanethiol is prepared after mixing ethylene sulfide and diethylamine under the condition of adding catalyst and heating the mixture to 50-80 DEG C for reaction. In the method, under the condition of presence of the catalyst, the raw materials can fully react without using any solvent and the ethylene sulfide can be effectively prevented from self polymerization, thus obtaining the products with high yield and quality. Meanwhile, without producing the three wastes, the method effectively protects the environment.

Description

technical field [0001] The invention relates to a method for synthesizing a compound, in particular to a method for synthesizing N,N diethylaminoethanethiol. Background technique [0002] N, N diethylaminoethane mercaptan is a key intermediate in the production of veterinary fungicide tiamulin. Due to the gradual expansion of domestic and foreign markets for tiamulin in recent years, the intermediate N, N diethylamino ethanethiol has The demand has also increased, about 250 tons / year. According to the records of domestic and foreign documents, there are altogether six process routes in the prior art, which are respectively ethyl chloroformate route, thiohydrogen salt route, thiocyanate route, benzyl mercaptan route, thiourea route and ethylene sulfide route. [0003] Wherein, the ethyl chloroformate route is as follows: [0004] [0005] This method has a long route and uses hydroxyethane mercaptan, a highly toxic controlled product, so it is not easy to obtain and th...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C323/25C07C319/06B01J31/02B01J31/14
CPCY02P20/584
Inventor 赵云现李超
Owner 河北远大九孚生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com