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Magnetic polyacrylic acid modified carbon nano-tube medicament carrier

A technology of polyacrylic acid and nanotubes, which can be used in drug combinations, antineoplastic drugs, and pharmaceutical formulations. It can solve the problems of difficult control of particle size, no help, poor targeting, etc., and achieve good magnetic field positioning effect, inhibit proliferation, Improve the effect of treatment

Inactive Publication Date: 2009-06-24
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These carriers have played a certain role in lymphatic chemotherapy, but there are still some unsatisfactory aspects, such as small drug loading, difficult to control particle size, poor targeting, cannot be used as tracers, and are not helpful for diagnosis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1 Preparation of magnetic polyacrylic acid modified carbon nanotube drug carrier

[0041] Reagents and raw materials

[0042] 1. Multi-walled carbon nanotubes (MWNTs): prepared by vapor co-deposition method, purchased from Shenzhen Nanoport Co., Ltd., with a purity of more than 95% and a diameter of 10 to 80 nm;

[0043] 2. Ferrous chloride tetrahydrate (FeCl 2 ·4H 2 O): purchased from Sigma-Aldrich (Shanghai) Trading Co., Ltd.;

[0044] 3. Ferric chloride hexahydrate (FeCl 3 ·6H 2 O): purchased from Sigma-Aldrich (Shanghai) Trading Co., Ltd.;

[0045] 4. Sodium dodecyl benzene sulfonate (SDBS): purchased from Sigma-Aldrich (Shanghai) Trading Co., Ltd.;

[0046] 5. Acrylonitrile (AN): Purity>99%, purchased from Fluka Reagent Co., Ltd.;

[0047] 6. Azobisisobutyronitrile (AIBN): Purity>98%, purchased from Shanghai Chemical Reagent Factory;

[0048] 7. Hydrochloric acid, methanol and NaH 2 PO 4 All purchased from Shanghai Chemical Reagent Factory;

[0049] 8. Deionize...

Embodiment 2

[0056] Example 2 Preparation of a nude mouse model of human malignant tumor lymphatic metastasis

[0057] Cell lines and laboratory animals

[0058] 1. BxPC-3 human pancreatic cancer cell line, purchased from Institute of Cell Research, Shanghai Branch of Chinese Academy of Sciences;

[0059] 2. BALB / C-nu / nu nude mice, purchased from Shanghai Slack Laboratory Animal Co., Ltd.

[0060] Cell culture materials

[0061] 1.1640 culture medium: purchased from Gibco-BRL company;

[0062] 2. Trypsin: purchased from Huamei Biotechnology Co., Ltd.;

[0063] 3. Preparation of PBS solution;

[0064] 4. Calf serum: product of Huamei Biotechnology Co., Ltd.;

[0065] 5. Cell culture plate and cell culture flask: purchased from Corning Costar;

[0066] 6. Cell culture dishes and cell cryopreservation tubes: purchased from Nunc.

[0067] Establishment of a nude mouse model of human pancreatic cancer lymphatic metastasis

[0068] A nude mouse model of human pancreatic cancer lymphatic metastasis w...

Embodiment 3

[0074] Example 3 Lymphatic tropism experiment of magnetic polyacrylic acid modified carbon nanotubes

[0075] Experimental animal

[0076] 1. SD rats: male and female, 4 to 5 weeks old, weighing 100 to 150 g, purchased from Shanghai Slack Laboratory Animal Co., Ltd., and reared routinely.

[0077] 2. Human pancreatic cancer lymphatic metastasis nude mouse model: established according to the above method.

[0078] A control experiment on the tracing performance of magnetic polyacrylic acid modified carbon nanotubes on rat lymph nodes

[0079] The rats were divided into 4 groups. Each rat was injected with 0.1ml subcutaneously inside the paw pad of the left hind limb. The magnetic polyacrylic acid modified carbon nanotube suspension was divided into 3 concentrations. The magnetic activated carbon was used as a control. Observe the degree of black staining of the lymph nodes in different parts of the injection area and the lymphatic drainage route, and take the black stained lymph no...

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Abstract

The invention belongs to the field of molecule biological medicine, and relates to a magnetic polyacrylic acid-modified nanometer pipe and a method for preparing the same. A multi-wall carbon nanometer pipe is modified by polyacrylonitrile and hydrolyzed under acid condition to obtain a polyacrylic acid-modified water-soluble nanometer pipe containing large quantity of carboxyl groups; by the water-phase chemical co-precipitation method, a magnetic ferroferric oxide-polyacrylic acid-modified multi-wall carbon nanometer pipe composite with the diameter of between 10 and 80nm is prepared, and the composite has good lymphotaxis and strong magnetic response; tests show that a medicine carrier can effectively adsorb chemical treatment medicines to a lymphatic system, slowly release the chemical treatment medicines in a metastasis lymph node of a malignant tumor, has good magnetic field positioning effect and obviously inhibits the proliferation and metastasis of the tumor cell of the lymph node. The invention provides a novel intervention means for lymphatic metastasis of the malignant tumor.

Description

Technical field [0001] The invention belongs to the field of molecular biomedicine manufacturing, and relates to a new carrier for malignant tumor lymphatic magnetic guidance chemotherapy, and in particular to a new carrier with magnetic guidance function for the treatment of malignant tumor lymph node metastasis-magnetic polyacrylic acid modified carbon nanotubes and the same Preparation. Background technique [0002] A large number of clinical studies have proved that lymph node metastasis is one of the most important metastasis pathways of malignant tumors, and it is also an important factor affecting its prognosis. However, although the diagnosis and comprehensive treatment of malignant tumors have made great progress, the survival time of most cancer patients with lymph node metastasis has not been significantly prolonged. The main reasons include that radiotherapy and systemic chemotherapy have unsatisfactory effects on lymph node metastasis and have large toxic side effect...

Claims

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Application Information

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IPC IPC(8): A61K47/34A61K47/04A61K31/7068A61P35/00A61P35/04A61K47/32
Inventor 杨峰倪泉兴傅德良金忱虞先浚龙江徐近杨东胡建华汪长春
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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