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Sealwort polysaccharide and preparation method thereof, and its application in preparing hypoglycemic and reducing blood lipid drugs

The technology of polysaccharide polysaccharide and polysaccharide polysaccharide is applied in the field of polysaccharide polysaccharide, which can solve the problems of many impurities, affecting the medicinal effect of polysaccharide polysaccharide, and low purity of polysaccharide polysaccharide, achieving good purity, low requirements for preparation equipment and place, and simple and easy preparation process. Effect

Inactive Publication Date: 2009-06-17
海南思坦德科技集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Polygonatum polysaccharides extracted by this method have low purity and more impurities, which affect the medicinal effect of Polygonatum polysaccharides

Method used

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  • Sealwort polysaccharide and preparation method thereof, and its application in preparing hypoglycemic and reducing blood lipid drugs
  • Sealwort polysaccharide and preparation method thereof, and its application in preparing hypoglycemic and reducing blood lipid drugs
  • Sealwort polysaccharide and preparation method thereof, and its application in preparing hypoglycemic and reducing blood lipid drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0030] Take 1 kg of Rhizoma Polygonatum medicinal material, add 10 times of the weight of the medicinal material and boil to extract for 3 hours, filter with suction, add 8 times of water to the dregs and boil to extract for 1 hour, combine the filtrates twice, concentrate under reduced pressure to 50% of the original volume of the filtrate, filter with suction, Add 95% (v / v, the same below) ethanol to the filtrate to a final alcohol concentration of 20% (v / v, the same below), let stand, centrifuge in a high-speed centrifuge, and suction filter, add 95% ethanol to the filtrate to a final alcohol concentration of 70% , stand still, centrifuge, take the precipitate, wash the precipitate twice with 95% ethanol and acetone respectively, and dry under reduced pressure to obtain 40.34 g of crude Polygonatum polysaccharide.

[0031] Get the Polygonatum polysaccharide crude product, add water that is equivalent to 25 times the weight of the crude product to dissolve, suction filter, ad...

experiment example

[0038] Drug efficacy test results

[0039] I, sample source: Polygonatum polysaccharide sample is made by the embodiment method, and purity is more than 85%.

[0040] II. Experimental animals: Kunming mice, provided by the Experimental Animal Center of Kunming Medical College.

[0041] III. Test methods and results:

[0042] (1), Polygonatum polysaccharide prevents the effect of hyperlipidemia in mice

[0043] A number of Kunming mice were randomly divided into 6 groups, as shown in Table 1 and Table 2. Continuous intragastric administration for 10 days, the blank group was given normal saline, and the other groups were given corresponding drugs. 0.5ml / 25g of egg yolk milk was intraperitoneally injected 1 hour after the last administration. The blank group was intraperitoneally injected with 0.5ml of normal saline. After 20 hours, blood was taken from the orbit (without food and water for 12 hours), centrifuged at 2500 rpm at low temperature, and the supernatant serum was...

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PUM

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Abstract

The invention provides a polygonatum canaliculatum polysaccharide and a preparation method thereof. The polygonatum canaliculatum polysaccharide is extracted from the perennial liliaceae herbal plant of polygonatum canaliculatum and has the molecular weight of 5,000 to 100,000 Daltons. The solid polygonatum canaliculatum polysaccharide is off white or white. The monosaccharide consists of pyrane type beta-D-galactose, D-glucose and D-mannose. The product can be developed into medicines capable of reducing blood sugar and blood fat. The preparation method is reliable and feasible, and is suitable for the volume product without environmental pollution. The preparation method has low cost.

Description

technical field [0001] The invention relates to Polygonatum polysaccharide, in particular to its preparation method and medical application. Background technique [0002] Polygonatum, also known as Immortal Yuliang, Tiger Ginger, Chicken Head Ginseng, etc., is a perennial herb of the genus Polygonatum in the family Liliaceae. The smell is mild, the texture is moist, and it has the effect of nourishing the yin of the lungs, moistening dryness and promoting body fluid. In recent years, there have been many research reports on the active substances of Polygonatum Polysaccharides, such as the functions of Polygonatum Polysaccharides in lowering blood sugar and delaying the lifespan of Drosophila. Polygonatum has three major components: ① fat-soluble steroidal saponins; ② flavonoids and anthraquinones; ③ water-soluble components—Polygonatum polysaccharides. [0003] Polygonatum is a commonly used traditional Chinese medicine, which is widely used clinically and has achieved goo...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61K31/715A61P3/10A61P3/06
Inventor 韩金光
Owner 海南思坦德科技集团有限公司
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