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Ceramide preparation pure dry powder, and preparation and application thereof

The technology of ceramide and galactosylceramide, which is applied in the field of biochemistry, can solve the problems of easy oxidative discoloration, heavy odor of preparations, cannot be stored at room temperature, etc., and achieves the effects of not easy oxidative discoloration, reduced phospholipid content and low production cost.

Inactive Publication Date: 2009-06-03
SHANGHAI HOPE TEC BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] 2. The preparation is khaki, easy to oxidize and change color, and cannot be stored at room temperature. The color of the preparation will turn brown after a long time
[0009] 3. The preparation has a heavy odor
[0010] In China, there is no pure dry powder product of ceramide preparations on the market so far, and this pure dry powder product is still a blank commodity in the bioactive substance market

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Example 1 Preparation of pure dry powder of ceramide preparation. This example is completely operated according to the specific operation steps of the above-mentioned method for preparing pure dry powder of ceramide preparations. Therefore, in each of the following steps, only the key technical parameters need to be listed.

[0053] In the first step, 100 grams of raw materials were weighed; in the second step, the amount of ethanol added was 300 milliliters; in the third step, heated to 70°C and kept for 1 hour; in the fourth step, placed at 4°C and cooled for 20 hour; in the sixth step, the amount of ethanol added was 200 milliliters; in the seventh step, heated to 70°C and kept for 1 hour; in the eighth step, placed at 4°C and cooled for 20 hours; in the tenth step, 35 gram product Ceramide preparation pure dry powder.

[0054] The above product indicators:

[0055] 1. Appearance: White dry powder.

[0056] 2. Smell and taste; no peculiar smell.

[0057] 3. Loss on...

Embodiment 2

[0066] Example 2 Preparation of ceramide liposome emulsion. This embodiment operates completely according to the specific operation steps of the above-mentioned method for preparing ceramide liposome emulsion, therefore, in each of the following steps, only the key technical parameters need to be listed.

[0067] In the first step, weigh 30 grams of pure dry powder of ceramide preparation; in the second step, the amount of medical ethanol added is 10 ml; in the third step, heat to 70°C; Inject 1000 ml of distilled water with a needle size of 65 °C, and the speed of the electric mixer is 900 rpm; in the sixth step, continue stirring for 30 minutes at 60 °C; in the seventh step, 1000 ml of the product ceramide is prepared liposome emulsion.

[0068] The above-mentioned product is a high-quality ceramide liposome emulsion with milky white color and no peculiar smell, and its technical indicators are as follows:

[0069] 1. Appearance: milky white, odorless emulsion.

[0070] 2...

Embodiment 3

[0075] Example 3 The method of preparing cosmetics with moisturizing function by using pure dry powder of ceramide preparation. This example is completely operated according to the specific operation steps of the above-mentioned method for preparing cosmetics with moisturizing function by using pure dry powder of ceramide preparations. Therefore, in each of the following steps, only the key technical parameters need to be listed.

[0076] Taking skin care milk as raw material, take 100 grams of skin care milk, add 0.055 g of pure dry powder of ceramide preparation to the skin care milk, and obtain 100.055 grams of ceramide-containing skin care milk with moisturizing function.

[0077] Tewameter TM 210 (Courage+Khazaha, Koln, Germany) was used to measure the skin transdermal water loss value (TEWL) of the skin care milk with moisturizing function and the control skin care milk. The results showed that: the skin transdermal water loss value of the former was 87%; The latter has ...

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PUM

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Abstract

The invention relates to a ceramide preparation pure dry powder which is white without peculiar smell and is made from galactosyl ceramide, phosphatide and cholesterol which are mixed uniformly. The weights of the galactosyl ceramide, the phosphatide and the cholesterol respectively take 60 percent to 70 percent, 20 percent to 25 percent and 10 percent to 15 percent in the total weight of the dry powder. A dry pasty ceramide preparation developed by East China Normal University and ethanol are used as raw material and extracting solution respectively. The ethanol is used for extracting ceramide from the dry pasty ceramide preparation twice, the extract is frozen and dried, and the dry powder is prepared. The dry powder is used as the raw material; a small quantity of 95 percent medical ethanol is added to be heated and dissolved and injected into hot stirred distilled water by an injector; and ceramide lipidosome emulsion is prepared. The dry powder is added into cosmetic; the addition is 0.01 percent to 0.1 percent of the weight of the cosmetic; the dry powder and the cosmetic are stirred uniformly; and the cosmetic with moisturizing function is prepared.

Description

technical field [0001] The invention relates to a pure dry powder of ceramide preparation and its preparation and application, belonging to the technical field of biochemistry. technical background [0002] Sphingolipids are important components of cell membranes and widely exist in animals and plants, especially in animal brain and nerve tissues. The parent structure of sphingolipids is ceramide, which is formed by linking one molecule of sphingosine and one molecule of long-chain fatty acid. [0003] In recent years, the results of skin research have shown that lipids that exist between skin keratinocytes are important substances for maintaining skin health. The main components are ceramide and its glycosyl derivatives, and the secondary components are cholesterol and cholesterol esters. . Ceramide and its glycosyl derivatives are important substances for protecting the skin. Their skin care functions in the stratum corneum of the epidermis mainly include: barrier effect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/68A61Q1/12A61Q19/00
Inventor 王纪文秦德安何学民
Owner SHANGHAI HOPE TEC BIOTECH
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