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Antineoplastic combined medicament with enhancing and poison-reducing character

A technology with anti-tumor and anti-tumor activity, which can be used in anti-tumor drugs, medical formulations containing active ingredients, drug combinations, etc.

Inactive Publication Date: 2009-05-13
GUANGZHOU YUNZHONG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still two characteristics of this type of drug - fat solubility and safety have not been fully applied to the research and development of anti-tumor combination drugs

Method used

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  • Antineoplastic combined medicament with enhancing and poison-reducing character
  • Antineoplastic combined medicament with enhancing and poison-reducing character
  • Antineoplastic combined medicament with enhancing and poison-reducing character

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 Tumor cell types and cell culture method thereof

[0018] Cell lines and cell culture: The cells used in the experiment include cervical cancer Hela cells, brain glioma SWO-38 cells, liver cancer HepG2 cells, lung cancer LAC cells and breast cancer MCF-7 cells. The culture conditions of all cells are as follows: in a carbon dioxide cell incubator (37°C, saturated humidity, CO 2 Content 5%), grown in RPMI-1640 culture medium containing 10% fetal bovine serum and 100U / mL antibiotics. Cells were passaged every 3 to 4 days.

Embodiment 2

[0019] Example 2 Inhibitory effect of dihydroartemisinin and teniposide on tumor cell growth

[0020] Drug action: Collect cells in the logarithmic growth phase and disperse them in the culture medium to contain 5×10 4 A single cell suspension of cells. The cell suspension was inoculated in 96-well cell culture plates at 100 microliters per well, and cultured in a carbon dioxide cell incubator for 24 hours. The original culture solution was discarded, and 100 microliters of culture solution containing the drug to be tested was added to each 3 wells as a detection concentration, and the culture was continued for 72 hours to observe the effect of the drug on cell growth. In the experiment, the blank control of culture medium and the control of cells without drug treatment were set up. The half inhibitory concentration of drugs on cell growth was determined by MTT method.

[0021]The basic operation of the MTT method used: After the cells in the 96-well plate were treated with...

Embodiment 3

[0031] Example 3 Synergistic or synergistic effect of dihydroartemisinin combined with teniposide in inhibiting the growth of certain tumor cells

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Abstract

The invention relates to an antineoplastic compound medicine having synergism and attenuation effects. The compound medicine mainly comprises teniposide and derivant of arteannuin. Owing to the synergism and attenuation effects in inhibiting the growth of specific tumor cells, the compound medicine is suitable for preparing antineoplastic medicine, particularly for preparing medicines for treating cerebral glioma, liver cancer and cervical carcinoma.

Description

technical field [0001] The invention relates to an anti-tumor combined drug with the characteristics of synergistic and attenuated toxicity, in particular to an anti-tumor combined drug used for preparing drugs for treating brain glioma, liver cancer and cervical cancer, and belongs to the technical field of anti-cancer drugs. Background technique [0002] Glioma is also called glioma. The treatment of glioma is mainly surgical treatment, but because the tumor grows infiltratingly and has no obvious boundary with the brain tissue, it is difficult to completely remove it except for early tumors that are small and located in appropriate locations. Treatment, that is, postoperative radiation therapy, chemotherapy, etc., can delay recurrence and prolong survival. Glioma is one of the main types of brain tumors. Due to the factors of the blood-brain barrier, the main chemotherapy drugs include chemotherapeutic agents such as temozolomide and teniposide. These chemotherapeutic ag...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/365A61K31/357A61P35/00
Inventor 沈小玲
Owner GUANGZHOU YUNZHONG BIOTECH
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