Synthetic method of superficially pellicular packing stuffing for strong-acid cation chromatographic column and product

Abstract

The invention provides a method for synthesizing fillers for a surface-pellicular highly-acidic cationic chromatographic column. The method comprises the following steps: synthetic shape-crosslinking aromatic olefin organic matrix resin is sulphonated and then packed into a column, and the synthetic shape-crosslinking aromatic olefin organic matrix resin reacts with concentrated sulphuric acid or chlorosulfonic acid at a temperature between 5 and 40 DEG C, so as to perform sulfonation treatment. The synthetic shape-crosslinking aromatic olefin organic matrix resin is subjected to the sulfonation treatment under the condition of low temperature, thereby ensuring that the sulfonation degree is low and the resin can not be damaged when the reaction is stopped. The aromatic olefin organic matrix resin with high synthetic shape-crosslinking degree is high in strength and strong in the performance of tolerating organic solvents. A resin product produced by the synthesis method has good integrity. When having higher crosslinking degree, the synthetic resin is good in the performance of tolerating the organic solvents.

Description

technical field [0001] The invention relates to a chromatographic column filler, in particular to a synthesis method and a product of a surface thin-shell type strongly acidic cation chromatographic column filler. Background technique [0002] In "A Novel Ion Exchange Chromatography Using a Conductivity Detector" published by Analytical Chemistry (ANAL.CHEM.47 (1975) 1801), Small of the United States proposed the use of styrene-divinylbenzene copolymers with a cross-linking degree of 2%. The sulfonation reaction is carried out at 90-100°C for 1-10 minutes, and then the reactants are poured into cold deionized water. This technology has a high sulfonation temperature, and the resin is easily broken when poured into cold deionized water, resulting in The degree of dispersion of the resin becomes larger, and there is no exchange group at the broken interface, which reduces the separation effect and reduces the strength of the cracked resin. In addition, this technology has a l...

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Problems solved by technology

[0002] In "A Novel Ion Exchange Chromatography Using a Conductivity Detector" published by Analytical Chemistry (ANAL.CHEM.47 (1975) 1801), Small of the United States proposed the use of styrene-divinylbenzene copolymers with a cross-linking degree of 2%. The sulfonation reaction is carried out at 90-100°C for 1-10 minutes, and then the reactants are poured into cold deionized water. This technology has a high sulfonation temperature, and the resin is easily broken when poured into cold deionized water, resulting in The degree of dispersion of the resin becomes larger, and there is no exchange group at the broken interface, which reduces the separation effect and reduces the strength of the cracked resin.

In addition, this technology has a low degree of crosslinking and poor resistance to organic solvents. In organic solvents, styrene-divinylbenzene resin is easy to swell and lose its exchange capacity.

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