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Red clover extract and preparation method thereof

A technology for red clover and its extract is applied in the field of red clover extract and its preparation, which can solve the problems of unsuitability for industrialized production, serious chemical pollution, complicated preparation steps and the like, and achieves controllable product quality, high yield, Good operability

Active Publication Date: 2009-04-01
TIANJIN TASLY MORDEN TCM RESOURCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] Although this method avoids the use of resin columns, the disadvantages of low yield and incomplete extraction cannot be avoided if neutral alumina is used instead of resin columns for adsorption; secondly, a large amount of organic solvents are used in the preparation process, and the chemical pollution is relatively high. Seriously, for the staff, the metabolism in the body is relatively slow after inhalation, causing great harm to the body; again, the preparation steps are cumbersome and difficult to operate, so it is not suitable for industrial production

Method used

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  • Red clover extract and preparation method thereof

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Effect test

Embodiment 1

[0069] The preparation method of embodiment 1 extract

[0070] The red clover medicinal material is pulverized into coarse powder, extracted twice with 80% ethanol backflow, each 2 hours, the first time 80% ethanol consumption is 12 times of medicinal material, the second time is 10 times, filters, merges filtrate, reduces Concentrate and recover ethanol to a thick extract, add water to twice the amount of medicinal materials, stir at 60°C for 2 hours, place in a refrigerator overnight, centrifuge to obtain a precipitate, add 30% ethanol to twice the amount of medicinal materials, and store at 60°C Stir for 1.5 hours, place at room temperature overnight, centrifuge, take the supernatant and concentrate under reduced pressure to a specific gravity of 1.10-1.15, dry under reduced pressure to obtain the extract powder a, and prepare the dregs for later use. Add 50% ethanol to the dregs to double the amount of the medicinal materials , stirred at 60°C for 1.5 hours, placed at room...

Embodiment 2

[0071] The preparation method of embodiment 2 extract

[0072] The trifolium medicinal material is crushed into coarse powder, extracted twice with 80% ethanol under reflux, each time for 2 hours, the amount of 80% ethanol for the first time is 12 times that of the medicinal material, and the second time is 10 times, filter, combine the filtrate, and decompress Concentrate and recover ethanol to a thick extract, add water to double the amount of medicinal materials, stir at 60°C for 2 hours, place in a refrigerator overnight, centrifuge to obtain a precipitate, add 10-40% ethanol to it to double the amount of medicinal materials, and store at 50°C Stir under low temperature for 1.5 hours, place at room temperature overnight, centrifuge, take the supernatant and concentrate under reduced pressure to a specific gravity of 1.10-1.15, dry under reduced pressure to obtain the extract powder a, and prepare the dregs for later use. Add 40-50% ethanol to the dregs of the medicinal mate...

Embodiment 3

[0073] The preparation method of embodiment 3 extract

[0074] The trifolium medicinal material is crushed into coarse powder, extracted twice with 80% ethanol under reflux, each time for 2 hours, the amount of 80% ethanol for the first time is 12 times that of the medicinal material, and the second time is 10 times, filter, combine the filtrate, and decompress Concentrate and recover ethanol to a thick extract, add water to double the amount of medicinal materials, stir at 60°C for 2 hours, place in a refrigerator overnight, centrifuge to obtain a precipitate, add 10-40% ethanol to it to double the amount of medicinal materials, and store at 80°C Stir under low temperature for 1.5 hours, place at room temperature overnight, centrifuge, take the supernatant and concentrate under reduced pressure to a specific gravity of 1.10-1.15, dry under reduced pressure to obtain the extract powder a, and prepare the dregs for later use. Add 40-50% ethanol to the dregs of the medicinal mate...

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Abstract

The invention discloses a red clover extract and a preparation method thereof, red clover is taken, ethanol containing water is used for reflux extraction, filtrate is concentrated to obtain a liquid extract; water precipitation, placement and centrifugation are carried out on the liquid extract to obtain sediments; the ethanol containing the water is sequentially added in the sediments for gradient ethanol precipitation, the centrifugation is carried out, supernatant liquid with the corresponding ethanol concentration is taken, and the extract powder is obtained by concentrating and drying. The content of total isoflavones of the method is not less than 20 percent, the operation is simple and the cost is low, thereby being applicable to industrial production.

Description

technical field [0001] The invention relates to a plant extract, in particular to a red clover extract and a preparation method thereof. Background technique [0002] With the progress and development of society, the pace of life is accelerated, work pressure is increased, and high-intensity stressful life has resulted in a series of autonomic dysfunction diseases, such as climacteric syndrome and other diseases, which have brought great pain to patients and families. . According to epidemiological statistical estimates, menopausal women account for 20% of the total female population, and 80-90% of them will have symptoms of menopausal syndrome. Such as cardiovascular and cerebrovascular symptoms: hot flashes, sweating, vasospasm pain, high blood pressure, dizziness, tinnitus, vertigo, etc.; neuropsychiatric symptoms: emotional instability, nervousness and anxiety, insomnia and forgetfulness, and some people even have different personalities. Changes have taken place, seve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P15/12A61K133/00
Inventor 刘顺航马素珍闫立萍王平刘岩
Owner TIANJIN TASLY MORDEN TCM RESOURCES
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