Preparation method of morroniside and new use thereof

A technology of morroniside and medicine, applied in the field of preparation of morroniside and its new application

Inactive Publication Date: 2009-03-18
SHANDONG LUYE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the pharmacological effects of morroniside in the prevention or treatment of acute and chronic liver injury and liver fibrosis have not been reported. The inventors have confirmed the effect of morroniside in the prevention or treatment of acute and chronic liver injury and liver fibrosis through a large number of experimental studies. application in medicine

Method used

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  • Preparation method of morroniside and new use thereof
  • Preparation method of morroniside and new use thereof
  • Preparation method of morroniside and new use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1 Preparation of Morroniside

[0016] Cornus officinalis medicinal material 50Kg, pulverize, add 500L of water, soak for 2 hours, heat and decoct 3 times, each time for 2 hours, filter, combine the extracted filtrate, concentrate under reduced pressure to a relative density of 1.02 (measured at 40°C), add 95% ethanol, Stir until the ethanol concentration is 80%, let it stand for 12 hours, filter the ethanol solution, wash the filter residue with a small amount of ethanol, discard the filter residue, concentrate the filtrate to no alcohol, adjust the pH value to 2, and load the sample onto the AB-8 macroporous resin column, Wash with water until colorless, elute with 10% ethanol solution for 3 times the column volume, 30% ethanol solution for 3 times the column volume, receive the eluate, concentrate; the concentrated solution is loaded onto the HPD300 resin column, washed with purified water for 3 times the column volume, Wash with 10% liquid ethanol solution...

Embodiment 2

[0017] Example 2 Preparation of Morroniside

[0018] Grind 50Kg of Cornus officinalis medicinal material, add 500L of water, soak for 2 hours, heat and decoct 3 times, 2 hours each time, filter, combine and extract the filtrate, concentrate under reduced pressure until the relative density is 1.03 (measured at 40°C), add 95% ethanol, stir , until the alcohol concentration is 80%, let it stand for 6 hours, filter the ethanol solution, wash the filter residue with a small amount of ethanol, discard the filter residue, and concentrate the filtrate to no ethanol; adjust the pH of the concentrated solution to 2, and load it on the HZ-818 macroporous resin column , washed with water until colorless, eluted with 10% ethanol for 3 times the column volume, 20% ethanol for 3 times the column volume, 30% ethanol for 3 times the column volume, received the eluate and concentrated; the concentrated solution was loaded onto the HPD300 column , washed with water for 3 column volumes and 10% ...

Embodiment 3

[0019] Example 3 Preparation of Morroniside Injection

[0020] Take 2g of morroniside and 225g of sodium chloride according to the prescription, dissolve it with 25,000ml of water for injection, stir; add 25g of activated carbon, stir for 20 minutes, filter the solution through a microporous membrane to clarify, pack it into a 250ml infusion bottle, and sterilize it. After the inspection is qualified, it can be packed.

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PUM

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Abstract

The invention relates to a preparation method of morroniside and a new use thereof, in particular to the application of the morroniside in the preparation of drugs for preventing or treating acute and chronic liver injury and liver fibrosis and the preparation method of the morroniside.

Description

technical field [0001] The present invention relates to the application of an extract of Cornus officinalis in the preparation of medicines for preventing or treating acute and chronic liver injury and liver fibrosis, in particular to the use of morroniside in the preparation of medicines for preventing or treating acute and chronic liver injuries and liver fibrosis. application. Background technique [0002] In recent years, viral hepatitis, liver fibrosis, fatty liver, alcoholic liver, drug-induced liver damage, liver cirrhosis, liver cancer and other liver diseases are one of the major diseases threatening human health in today's society. my country is a big country with liver disease. According to the latest statistics, the carriers of viral hepatitis and hepatitis B virus have infected more than 14% of the population in our country. When the condition is exacerbated, it develops into liver fibrosis, hepatic ascites, hepatic peritoneum and liver cancer. There are more ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K36/40A61P1/16
Inventor 王春明耿桂华刘广蒋王林田京伟
Owner SHANDONG LUYE PHARMA CO LTD
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