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Disinfectant ointment

An ointment, sterilization and disinfection technology, applied in the directions of ointment delivery, application, biocide, etc., can solve the problems of alcohol skin irritation, continuous effect can not provide sufficient effect, skin damage, etc., to inhibit irritation, prevent infectious diseases, prevent Effects of skin damage

Inactive Publication Date: 2009-03-11
MARUISHI PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, any of these are alcohol-based disinfectants, which can cause skin irritation and skin damage from alcohol on the hands or other parts where the disinfectant is applied
Moreover, it does not actually provide a sufficient effect in terms of the above-mentioned sustained effect

Method used

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  • Disinfectant ointment
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～3、 comparative example 1 and 2

[0106] In Table 1, the oil phase components were heated to 75-80°C and stirred to dissolve, and then the temperature was adjusted to 60±2°C. The water phase components are heated to 65-70°C to completely dissolve the surfactant, and then the temperature is adjusted to 60±2°C. Next, while stirring with a homomixer, the oil phase was slowly added to the water phase. Afterwards, further stirred with the rotating speed of 8000rpm for 2 minutes, cooled to room temperature while stirring, finally obtained the ointment (preparation 1) of embodiment 1 in table 1, the ointment (preparation 2) of embodiment 2, the ointment of embodiment 3 Ointment (formulation 3), ointment of Comparative Example 1 (comparative formulation 1), and ointment of Comparative Example 2 (comparative formulation 2).

[0107] [Table 1]

[0108]

Embodiment 4

[0110] (1) Cetyl alcohol 4.0% by mass

[0111](2) Stearic acid 1.5% by mass

[0112] (3) Palm oil triglyceride 1.0% by mass

[0113] (4) Glyceryl triethylhexanoate 2.0% by mass

[0114] (5) Silicone oil 2.5% by mass

[0115] (6) Squalane 4.0% by mass

[0116] (7) POE (30) cholesteryl ether 4.0% by mass

[0117] (8) Glyceryl monostearate 1.0% by mass

[0118] (9) Ethanol 9.0% by mass

[0119] (10) Propylene glycol 18.0% by mass

[0120] (11) Glycerin 12.0% by mass

[0121] (12) Sodium pyrrolidone carboxylate 2.0% by mass

[0122] (13) Chlorhexidine gluconate 0.5% by mass

[0123] (14) Betaine 3.0% by mass

[0124] (15) pure water sufficient

[0125] Total 100.0% by mass

[0126] The above-mentioned components (1) to (10) are heated to 75 to 80° C. to dissolve, and then the temperature is adjusted to 70±2° C. to prepare an oil phase. On the other hand, the above-mentioned components (11) to (15) are heated to 70 to 75°C, and the tempera...

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PUM

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Abstract

Disclosed is a bactericidal disinfectant ointment containing 0.1-4% by mass of at least one substance selected from the group consisting of chlorhexidine and salts thereof and 8-25% by mass of a hydrocarbon alcohol having 2-3 carbon atoms. The bactericidal effect of this disinfectant ointment approved by hand disinfection test continues at least 6 hours.

Description

technical field [0001] The present invention relates to an ointment for sterilization and disinfection that provides quick-acting and continuous disinfection effects on human hands or skin. Background technique [0002] Chlorhexidine gluconate is a strong alkaline substance with strong antibacterial properties developed in England in 1954. This antibacterial property (disinfection property) is considered to be produced by the following mechanism. Chlorhexidine gluconate disrupts the bacterial cell membrane at relatively low concentrations, thereby causing irreversible leakage of intracellular components and enzyme inhibition, while at relatively high concentrations causes precipitation of intracellular proteins and nucleic acids. At present, chlorhexidine gluconate is used for disinfection of hands or skin, disinfection of surgical sites, disinfection of medical equipment and other disinfection purposes. According to different uses, chlorhexidine gluconate is used in the f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/155A61K9/06A61K47/10A61K47/12A61K47/14A61K47/16
CPCA61K47/14A61K47/24A61K47/06A61K47/12A61K47/10A01N47/44A61K9/0014A61K31/155A61P31/02A61P43/00A01N31/02A01N2300/00
Inventor 池田雅裕西原丰
Owner MARUISHI PHARMACEUTICAL CO LTD
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