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Compositions for vaginal use

A technology for vagina and vaginitis, applied in the direction of drug combination, drug delivery, plant raw materials, etc., can solve the problems of unavoidable adverse side effects, adverse side effects, etc.

Active Publication Date: 2009-02-25
POLICHEM SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Treatment by topical means with artificial estrogens (e.g., promestriene) is known in the art for the treatment of atrophic vaginitis, but this application cannot avoid adverse side effects, even serious ones, such as water retention and stimulation of tumor receptors such as breast tumor receptors

Method used

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  • Compositions for vaginal use
  • Compositions for vaginal use
  • Compositions for vaginal use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Preparation in gel form, prepared with the following components in p.b.w.% content:

[0042] Mother Hop Tincture (p.b.w.) 1%

[0043] Propylene Glycol 13% (p.b.w.)

[0044] Carbopol*980 0.75%

[0045] Soy Lecithin 0.8%

[0046] Cholesterol 0.20%

[0047] Vitamin E Acetate 0.02%

[0048] Sodium Hyaluronate 0.05%

[0049] Sodium Paraben 0.36%

[0050] Propylparaben Sodium 0.04%

[0051] Imidazolidinyl urea 0.20%

[0052] Disodium edetate 0.10%

[0053] Triethanolamine 0.2% (p.b.w.)

[0054] Purified water U.P. appropriate amount to 100%

[0055] *The term "Carbopol" is used to mean a homopolymer of acrylic acid crosslinked with polyalkenyl polyether.

[0056] a) The following ingredients are dissolved: Sodium Paraben 0.36% - Sodium Propylparaben 0.04% - Imidazolidinyl Urea 0.20% - Disodium EDTA 0.10% - Sodium Hyaluronate 0.05% in purified water U.P. 55% (p.b.w.) in

[0057] b) The following ingredients are dissolved: vitamin E acetate 0.02% - soybean lecithin...

Embodiment 2

[0062] Preparations in the form of gel creams, prepared with the following components in p.b.w.% amounts:

[0063] Mother Hop Tincture (p.b.w.) 1%

[0064] Propylene Glycol 13% (p.b.w.)

[0065] Carbopol 9800.75%

[0066] Soy Lecithin 0.8%

[0067] Cholesterol 0.20%

[0068] Vitamin E Acetate 0.02%

[0069] Sodium Hyaluronate 0.025%

[0070] Sodium Paraben 0.36%

[0071] Sodium Propyl Paraben 0.04%

[0072] Imidazolidinyl urea 0.20%

[0073] Disodium EDTA 0.10%

[0074] Triethanolamine 0.2% (p.b.w.)

[0075] Purified water U.P. appropriate amount to 100%

[0076] Step is the same as in Example 1

Embodiment 3

[0078] Preparation in the form of a fluid cream, prepared with the following ingredients in p.b.w.% content:

[0079] Mother Hop Tincture (p.b.w.) 1%

[0080] Propylene Glycol 13% (p.b.w.)

[0081] Carbopol 9800.75%

[0082] Soy Lecithin 0.64%

[0083] Cholesterol 0.16%

[0084] Vitamin E Acetate 0.02%

[0085] Sodium Hyaluronate 0.025%

[0086] Sodium Paraben 0.36%

[0087] Sodium Propyl Paraben 0.04%

[0088] Imidazolidinyl urea 0.20%

[0089] Disodium EDTA 0.10%

[0090] Triethanolamine 0.2% (p.b.w.)

[0091] Purified water U.P. appropriate amount to 100%

[0092] Step is as in embodiment 1

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PUM

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Abstract

The subject of the invention is compositions for vaginal use containing lupulus (Humulus lupulus) and an excipient base suitable for application in the vaginal and / or vulvar region, for the treatment of vaginal dryness (atrophic vaginitis) and of the disorders correlated thereto, pruritus, burning sensation, dryness, dyspareunia; they are also particularly useful for delaying and attenuating the changes in the physiological trophism of the vulvar and vaginal tissue and mucosa.

Description

field of invention [0001] The object of the present invention is a vaginal composition comprising hops (Humulus lupulus) as an active ingredient, used for the preparation of specific medicine products, or medical equipment, or cosmetics, or hygiene products, suitable for application to the vagina and / or vulva area, available Treatment of vaginal dryness (atrophic vaginitis) and conditions related thereto, itching, burning, dryness, dyspareunia; they are further particularly useful for delaying and attenuating trophic changes in the physiology of vulvar and vaginal tissues and mucous membranes. Background of the invention [0002] Vaginal dryness (atrophic vaginitis) can have various causes, including pathological ones, but it is more often a paraphysiological condition very common during menopause, caused by the effects of estrogen circulating in the blood Caused by tapering (hypoestrogenism); this physiological decrease in estrogen includes a decrease in cellular glycogen a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P15/02
CPCA61K36/185A61K9/0034A61P15/00A61P15/02
Inventor M·迪斯彻纳
Owner POLICHEM SA
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