Use of calcium metaphosphate as non-hard tissue engineering material

Abstract

The invention discloses the usage of calcium metaphosphate (CMP) as non-hard-tissue engineering materials. The non-hard-tissue engineering materials can also be made of the single material of calcium metaphosphate, but can also be formed by the compounding of calcium metaphosphate and polymer materials, and the polymer materials comprise one or more of polylactic acid, polyglycolic acid, poly hydroxybutyric acid, polycaprolactone, polyurethane, polyanhydride, collagen, chitosan, gelatin, hyaluronic acid and fibrin protein gel. The calcium metaphosphate provides cell affinity and the polymer materials provide mechanical property. Compared with the prior art, the invention has the advantages that in the CMP / polymer composite materials, the polymer materials provide a stable mechanical environment and are easy to shape; and the CMP promotes cell adhesion and affinity. Before the adsorption of the CMP composite support materials, cells have been amplified to a sufficient number and to generate sufficient extracellular matrix, thereby enhancing the adhesion capacity of cells and materials, and enhancing the anticoagulation and antithrombotic capacity of the tissue engineering supports.

Description

technical field [0001] The invention relates to the use of calcium metaphosphate as a non-hard tissue engineering material, and belongs to the technical field of biological materials and tissue engineering. Background technique [0002] Calcium Metaphosphate glass ceramics (CMP) material is a very new tissue engineering scaffold material. For example, biomaterials scientist Monem AS found that after the surface of titanium metal was modified by CMP ceramics, its combination with animal tissues was more tightly. Biomaterials scientist Park EK et al inoculated MSC cells on the surface of their self-made CMP blocks, and carried out cytotoxicity experiments, proliferation experiments, morphological analysis and gene expression monitoring. Under the action of these factors, it can promote the expression of several bone-related genes such as ALP and OPG. These studies all affirmed the superior biocompatibility, degradation performance and mechanical properties of CMP, but due to...

AI Technical Summary

Problems solved by technology

At present, calcium metaphosphate / polymer composite materials are mostly used in fracture internal fixation materials, such as patent CN101143230A, which discloses a kind of calcium metaphosphate whisker-reinforced polylactic acid fracture internal fixation material prepared by two-step molding method, and non-hard tissue Application not yet reported

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