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Medicine composition containing silymarin and kurainone or matrine and use thereof

A technology of silybin and matrine, which is applied in the treatment of liver diseases and diseases, and can solve problems such as large side effects, adverse family effects, and long treatment courses

Inactive Publication Date: 2009-02-04
江苏盈科生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its etiology and pathogenesis are extremely complex, and there is no definite and effective drug for its prevention and treatment.
In clinical practice, TCM syndrome differentiation and treatment are mostly used, and some auxiliary drugs are added to improve the curative effect, but the prognosis of many patients is very poor, which brings adverse effects to society and family
[0003] Matrine, also known as oxymatrine, has the same pharmacological efficacy as matrine, and has certain anti-hepatitis virus and liver protection effects. It has been used to treat chronic hepatitis clinically, but the clinical efficacy of oxymatrine or matrine The curative effect is uncertain, and there are side effects such as diuresis and sodium excretion, so patients with excessive urine output should not use it
Silibin has hepatoprotective effect and has been used clinically to treat chronic hepatitis. The bioavailability of silibinin orally is low and the course of treatment is long. However, due to the poor water solubility of silibinin, it is necessary to add a cosolvent or mix It is prepared into water-soluble salt, such as CN1762344, it is prepared into meglumine salt or amino acid salt to increase the water solubility of silibinin; it can also directly increase the solubility by adjusting the pH value, but the side effects are relatively large; its intravenous injection Drug administration and no domestic products listed

Method used

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  • Medicine composition containing silymarin and kurainone or matrine and use thereof
  • Medicine composition containing silymarin and kurainone or matrine and use thereof
  • Medicine composition containing silymarin and kurainone or matrine and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Matrine 100mg

[0048] Silibinin 100mg

[0049] Microcrystalline Cellulose 13.0mg

[0050] Appropriate amount of lactose

[0051] Magnesium Stearate Appropriate amount

[0052]

[0053] 237.5mg per tablet

[0054] After uniformly mixing the above-mentioned raw materials and auxiliary materials, it is wet granulated according to the conventional method, dried and pressed into tablets.

Embodiment 2

[0056] Matrine 50mg

[0057] Silibinin 50mg

[0058] NaCl 0.9g

[0059] Appropriate amount of water for injection

[0060]

[0061] 100ml each

[0062] Take sodium chloride, stir and dissolve with water for injection, then add matrine and silibinin respectively, continue to stir to dissolve completely, add water for injection to the total amount, filter until clear, potting, and sterilize to obtain.

Embodiment 3

[0064] Pill Core Prescription

[0065] Matrine 150g

[0066] Silybin 150g

[0067] Microcrystalline Cellulose 15g

[0068] Hypromellose 5g

[0069] Pure water 200ml

[0070]

[0071] Makes 1000 capsules

[0072] Coating prescription

[0073] 25% based cellulose aqueous dispersion 184g

[0074] Pure water 123g

[0075]

[0076] Makes 1000 capsules

[0077] Microcrystalline cellulose, matrine, and silybin were crushed through 80-mesh sieve in advance, weighed according to the prescription of pill 1, mixed evenly, and hydroxypropyl methylcellulose aqueous solution was used as a binder to make micropills. Dry at 50-60°C, select pellets of 20-30 mesh, and set aside. Put the prepared and selected pellets in a fluidized bed, adopt the bottom spray method, and suspend and fluidize them by hot air. Provide the coating solution at a rate of 5 g slurry per minute, atomize at 2 bar, and start spraying the fluidized ...

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PUM

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Abstract

The invention relates to the medicine field, in particular to a compound medicine combination which contains silybin and oxymatrine or matrine and the application of the combination for curing liver diseases, and more particularly relates to the application for curing diseases such as hepatitis, liver damage and liver cancer.

Description

technical field [0001] The present invention relates to the field of medicine, in particular to a compound pharmaceutical composition containing silibinin and matrine or matrine, and the use of the composition for treating liver diseases, especially for treating hepatitis and liver damage and diseases such as liver cancer. Background technique [0002] Liver disease is a frequently-occurring and common disease in our country. Its etiology and pathogenesis are extremely complex, and there is no definite and effective drug for its prevention and treatment. Traditional Chinese medicine is often used in clinical treatment based on syndrome differentiation, and some auxiliary drugs are added to improve the curative effect. However, the prognosis of many patients is very poor, which brings adverse effects to society and families. [0003] Matrine, also known as oxymatrine, has the same pharmacological efficacy as matrine, and has certain anti-hepatitis virus and liver protection...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61K31/352A61P1/16A61P31/20A61K31/047
Inventor 崔秋菊
Owner 江苏盈科生物制药有限公司
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