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Hydrogenous injection having function for treating ischemia-reperfusion injury

A technology of injection and hydrogen, applied in the field of medicine

Inactive Publication Date: 2009-01-21
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are no relevant reports on the use of hydrogen-containing injections to prevent and treat ischemia-reperfusion injury

Method used

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  • Hydrogenous injection having function for treating ischemia-reperfusion injury
  • Hydrogenous injection having function for treating ischemia-reperfusion injury
  • Hydrogenous injection having function for treating ischemia-reperfusion injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1. Preparation of Hydrogen-containing Physiological Saline Injection

[0023] 1. Degassing treatment

[0024] Put a 500ml soft bag of physiological saline injection in a low-pressure chamber, treat it with 0.4ATA decompression at room temperature for 2 hours, take it out and place it at room temperature and pressure for 4 hours, and extract the precipitated gas with a syringe;

[0025] 2. Low temperature pretreatment

[0026] Place the above-mentioned degassed injection soft packaging bag at 2°C for 2 hours under normal pressure to fully cool it;

[0027] 3. Inject pure hydrogen

[0028] Extract 50ml of normal saline from the flexible packaging bag after the above-mentioned low temperature treatment, and inject 50ml of pure hydrogen gas (hydrogen standard gas of Shanghai Jiliang Standard Gas Co., Ltd., the same below) at 2°C under normal pressure;

[0029] 4. Pressurization to aid dissolution

[0030] Put the hydrogen-infused soft packaging bag of the inject...

Embodiment 2

[0031] Example 2. Preparation of Hydrogen Glucose Saline Injection

[0032] 1. Degassing treatment

[0033] Put the 500ml flexible packaging bag of glucose saline injection in a low-pressure chamber, treat it under reduced pressure at 0.8 ATA for 24 hours at room temperature, take it out and place it at room temperature and pressure for 24 hours, and extract the precipitated gas with a syringe;

[0034] 2. Low temperature pretreatment

[0035] Place the above-mentioned degassed injection soft packaging bag at 10°C for 8 hours under normal pressure to fully cool it;

[0036] 3. Inject pure hydrogen

[0037] Extract 25ml of injection solution from the above-mentioned low-temperature treated soft packaging bag, and inject 25ml of pure hydrogen at 10°C under normal pressure;

[0038] 4. Pressurization to aid dissolution

[0039] Put the hydrogen-infused soft packaging bag of the injection into the pressurized chamber, pressurize continuously at 7ATA for 24 hours at 1°C, then d...

Embodiment 3

[0040] Embodiment 3. preparation contains sodium bicarbonate injection

[0041] 1. Degassing treatment

[0042] Put the 100ml soft packaging bag of sodium bicarbonate injection in a low-pressure chamber, treat it under reduced pressure at room temperature with 0.6 ATA for 20 hours, take it out and place it at room temperature and pressure for 20 hours, and extract the precipitated gas with a syringe;

[0043] 2. Low temperature pretreatment

[0044] Place the above-mentioned degassed injection soft packaging bag at 6°C for 4 hours under normal pressure to fully cool it;

[0045] 3. Inject pure hydrogen

[0046] Extract 15ml of injection solution from the above-mentioned low-temperature treated soft packaging bag, and inject 15ml of pure hydrogen gas at 6°C under normal pressure;

[0047] 4. Pressurization to aid dissolution

[0048] Put the hydrogen-infused soft packaging bag of the injection into the pressurized chamber, pressurize continuously at 6ATA for 20 hours at 3°C...

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PUM

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Abstract

The invention relates to the field of medicine technology and provides an injection for curing ischemic-reperfusion damage of brain, heart, kidney and other tissue organs. The preparation method includes placing a medical injection flexible bag under low pressure for degasification, carrying out low-temperature pretreatment after air extraction, then injecting hydrogen for pressurized dissolution and dissolving hydrogen in the injection and storing under constant pressure and about 4 DEG C for standby. The injection can be used after 24-hour stabilization. The animal experiment proves that the injection of the invention can reduce focal cerebral ischemic-reperfusion damage in rats, neuron injuries and apoptosis number, decrease the activity of apoptosis enzyme in pallium and hippocampus, reduce the ischemic-reperfusion damage extent of heart and kidney and protect the function of ischemic-reperfusion heart and kidney. The hydrogen-included injection can be used as the medicine for curing the ischemic-reperfusion damages of brain, heart, kidney and other important organs.

Description

technical field [0001] The invention relates to the technical field of medicine, and is a hydrogen-containing injection that can be used for treating ischemia-reperfusion injury. Background technique [0002] Ischemia is one of the common causes of clinical diseases. Ischemic diseases can usually be treated by early measures such as thrombolysis and anti-free radical damage, but secondary ischemia-reperfusion injury may occur, which is an important pathophysiological process of diseases such as cerebral infarction. In the field of medical technology, hydrogen has been used in the treatment of saturation diving and decompression sickness. So far, there are no relevant reports on the use of hydrogen-containing injections to prevent and treat ischemia-reperfusion injury. Contents of the invention [0003] The invention provides a hydrogen-containing injection, which can be used for treating tissue damage and organ dysfunction caused by ischemia-reperfusion. [0004] The pr...

Claims

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Application Information

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IPC IPC(8): A61K33/00A61K9/08A61P9/10
Inventor 孙学军蔡建美康志敏刘文武茆丁张合徐伟刚陶恒沂
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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