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Rice fermented with red yeast extract, preparation method and quality detection method thereof

A technology of extract and red yeast rice, which is applied in the field of red yeast rice extract and its preparation method and quality inspection, and can solve the problems of low content of active ingredients in preparations, large dosage of drugs, and poor compliance of patients in taking them

Active Publication Date: 2008-12-03
BEIJING WBL PEKING UNIV BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The content of lovastatin, the main active ingredient in red yeast rice, is relatively low. Extraction according to conventional methods can increase the content of active ingredients in red yeast rice, but there are still problems of low active ingredient content in preparations and large doses of drugs. For severe cases For patients with dyslipidemia, it is more difficult to increase the dose, and the patient's compliance is poor

Method used

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  • Rice fermented with red yeast extract, preparation method and quality detection method thereof
  • Rice fermented with red yeast extract, preparation method and quality detection method thereof
  • Rice fermented with red yeast extract, preparation method and quality detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063]Get 3000g of red yeast rice medicinal material (the content of lovastatin in the medicinal material is determined to be 2.79mg / g by HPLC), add 75% ethanol 9000ml for the first time to extract under reflux for 3 hours, filter, add 75% ethanol 6000ml to extract for 2 hours , filter, combine two filtrates, reclaim ethanol under reduced pressure, concentrate into a thick paste without alcohol smell; add 3000ml of deionized water to the thick paste to precipitate, leave it at room temperature for 8 hours, siphon to remove the supernatant, and collect the precipitate; Add 90g of fine powder of red yeast rice to the precipitation, mix well, and dry in an oven at 80°C for 8 hours. After crushing, 174g of red yeast extract is obtained. The water content is 2.77% after determination, and the content of lovastatin in the extract is determined by HPLC It is 38.53 mg / g.

Embodiment 2

[0065] Take 1500g of red yeast rice medicinal material, add 4500ml of methanol for reflux extraction for 3 hours, filter the extract, add 3000ml of methanol for reflux extraction of the filter residue for 2 hours; filter the extract, combine the two filtrates, recover methanol under reduced pressure, evaporate the methanol and concentrate into a thick paste; Add 1875ml of deionized water to the thick paste for precipitation, place it under refrigeration for 2 hours, collect the precipitate by centrifugation, and sink it in water again in the same way; add 60g of microcrystalline cellulose to the precipitate, mix well and dry at 85°C After 10 hours, pulverize and pass through a 60-mesh sieve to obtain 96g of red yeast rice extract, the water content is 3.15% after determination, and the content of lovastatin in the extract is 40.33mg / g as measured by HPLC.

Embodiment 3

[0067] Get 1000g of red yeast rice medicinal material (the content of lovastatin in the medicinal material is determined to be 2.79mg / g by HPLC), add 3000ml ethyl acetate for reflux extraction for 2 hours, filter the extract, add 2000ml ethyl acetate for reflux extraction for 1 hour, extract Filter, add 2000ml ethyl acetate to the filter residue to reflux and extract for 1 hour, filter the extract, combine three filtrates, reclaim ethyl acetate under reduced pressure, evaporate the ethyl acetate and concentrate into a thick paste; add 500ml deionized water to the thick paste, fully Stir well, place at room temperature for 12 hours, centrifuge to remove the supernatant, discard the water, repeat this process twice; finally add 20g of pregelatinized starch to the precipitate, mix well, dry at 85°C for 7 hours, and crush for 60 Mesh sieve to obtain 45g of red yeast rice extract, the moisture content was determined to be 3.22%, and the content of lovastatin in the extract was deter...

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Abstract

The invention discloses a red yeast rice extract and a preparation method and a quality test method thereof. The main active ingredient of the extract is lovastatin, the content of which is more than 3 percent. The extract is prepared by subjecting a medical material of red yeast rice to extraction with an organic solvent, water decoction after the volatilization of the solvent, precipitation collection by siphonage and configuration, mixing with excipients and drying. The preparation method improves the content of lovastatin. The invention also provides a quality control method for identifying the ingredients and measuring content.

Description

technical field [0001] The invention designs an extract, a preparation method and a quality detection method thereof, and particularly relates to a red yeast extract, a preparation method and a quality detection method thereof. Background technique [0002] Since the 1980s, statins have been used to treat hyperlipidemia with remarkable curative effect. Among them, lovastatin is a kind of statins used in clinic earlier. It competitively inhibits cholesterol synthesis in the body. The rate-limiting enzyme hydroxymethylglutaryl coenzyme A (HMG-COA) reductase in the process reduces the synthesis of cholesterol and increases the synthesis of low-density lipoprotein receptors. The main site of action is in the liver, resulting in blood cholesterol and The level of low-density lipoprotein cholesterol is reduced, which has an effect on the prevention and treatment of atherosclerosis and coronary heart disease. Lovastatin also reduces serum triglyceride levels and increases high-den...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/06A61P3/06G01N21/31G01N21/78G01N33/02
Inventor 段震文郭树仁樊利青
Owner BEIJING WBL PEKING UNIV BIOTECH
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