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Isoquercitrin clathrate and preparation thereof

A technology of isoquercitrin and inclusion compound, which is applied in the field of isoquercitrin inclusion compound, can solve the problems of good water solubility of the isoquercitrin inclusion compound and the like, and achieves convenient industrial production, high inclusion rate, and preparation. The effect of simple and easy process

Inactive Publication Date: 2008-11-12
SHANXI UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The inclusion compound of isoquercitrin has good water solubility

Method used

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  • Isoquercitrin clathrate and preparation thereof
  • Isoquercitrin clathrate and preparation thereof
  • Isoquercitrin clathrate and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: Accurately weigh 0.1 g of methyl-β-cyclodextrin and add it to 30 ml of distilled water to dissolve it. Accurately weigh 0.05g of isoquercitrin, add it into 10ml of anhydrous methanol and dissolve it completely, then slowly add it dropwise into the above methyl-β-cyclodextrin aqueous solution under magnetic stirring, and keep stirring at a constant temperature of 50°C for 12 hours , Concentrated, dried at 50°C for 10 hours to obtain the inclusion compound of isoquercitrin-methyl-β-cyclodextrin.

[0028] The content (w / w) of isoquercitrin in the clathrate is 33.78%, the yield is 91.53%, and the encapsulation efficiency is 90.23%.

Embodiment 2

[0029] Example 2: Accurately weigh 0.48 g of β-cyclodextrin, add it to 25 ml of distilled water, and heat to 50° C. to dissolve it. Accurately weigh 0.2 g of isoquercitrin, add it into 10 ml of anhydrous methanol and dissolve it completely, slowly add it dropwise into the above-mentioned β-cyclodextrin aqueous solution under magnetic stirring, keep stirring at constant temperature for 12 hours, and place in the refrigerator for 4 Stand at ℃ for 24 hours, filter with suction, rinse gently with a small amount of methanol solution, and dry the precipitate at 50℃ for 10 hours to obtain the inclusion compound of isoquercitrin-β-cyclodextrin.

[0030] The content of isoquercitrin in the clathrate (w / w)=29.18%, the yield is 75.22%, and the encapsulation efficiency=75.16%.

Embodiment 3

[0031] Example 3: Accurately weigh 0.05 g of hydroxypropyl-β-cyclodextrin and add it to 30 ml of distilled water to dissolve it. Accurately weigh 0.185g of isoquercitrin, add it into 10ml of anhydrous methanol and dissolve it completely, then slowly add it dropwise into the above-mentioned aqueous solution of hydroxypropyl-β-cyclodextrin under ultrasonication, and continue ultrasonication at 50°C for 4 hours, After concentration, dry at 50°C for 10 hours to obtain the inclusion compound of isoquercitrin-hydroxypropyl-β-cyclodextrin.

[0032] The content (w / w) of isoquercitrin in the clathrate is 20.97%, the yield is 92.10%, and the encapsulation efficiency is 90.07%.

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Abstract

The present invention provides a clathrate compound formed by isoquercitrin and [beta]-cyclodextrin or derivatives thereof. The weight ratio of the isoquecitrin and the [beta]-cyclodextrin or the derivatives thereof is 1:2 to 20. The preparation method comprises the following steps of: dissolving the [beta]- cyclodextrin or the derivatives thereof into distilled water; putting the isoquercitrin into an organic dissolvant to dissolve; adding the isoquercitrin slowly into the water solution of the [beta]- cyclodextrin or the derivatives thereof, controlling the temperature and stirring; keeping stand, pumping-filtrating or directly condensing, vacuum drying, and obtaining the isoquercitrin clathrate compound. The solubility of the obtained isoquercitrin clathrate compound is significantly improved, and the isoquercitrin clathrate compound can be further developed into multiple solid dosage forms or liquid dosage forms which are suitable for medicines or food additives.

Description

technical field [0001] The invention relates to an inclusion compound of isoquercitrin, in particular to an inclusion compound composed of isoquercitrin and β-cyclodextrin or a derivative thereof and a preparation method thereof. Background technique [0002] Isoquercitrin belongs to flavonoid alcohol compounds. There is a molecule of glucose connected to the 3rd position of the flavone basic mother nucleus. The English name is Isoquercitrin and the molecular formula is C 21 h 20 o 12 , the molecular weight is 464.376. At present, domestic and foreign studies have shown that: isoquercitrin has anti-oxidation, anti-virus, lowering blood pressure, protecting liver and lowering enzymes, analgesia, enhancing estrogen secretion, etc. It is used as an active ingredient in oxygen, ischemic diseases and antithrombotic drugs. Therefore, isoquercitrin is often used as food additives, auxiliary drugs or active ingredients of drugs. [0003] However, isoquercitrin has the disadvant...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K31/7048A61P9/10A61P7/02A61K47/61A61K47/69
Inventor 李文超周叶红双少敏陕方周柏玲
Owner SHANXI UNIV
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