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Instant matched medical styptic anti-adhesive flush fluid

A flushing solution and anti-adhesion technology, which is applied in the field of surgical perioperative flushing solution, can solve problems such as inability to store for a long time, instability of chitosan aqueous solution, etc., and achieve the effects of promoting rapid healing, preventing implantation transfer, and inhibiting growth

Inactive Publication Date: 2008-09-10
XUZHOU HAIERZI BIOENG CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And solve the problem that chitosan aqueous solution is unstable and cannot be stored for a long time

Method used

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  • Instant matched medical styptic anti-adhesive flush fluid
  • Instant matched medical styptic anti-adhesive flush fluid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Such as figure 1 As shown, it is a ready-to-fit double chamber bag. The double-chamber bag is a non-PVC bag, and the non-PVC soft bag is divided into a chamber 1 and a chamber 2 with a weak sealing layer 3 in the middle. The water-soluble chitosan powder is packaged in the chamber 1, and the Sodium Chloride in Water for Injection.

[0041] Raw material: chitosan hydrochloride 0.5%

[0042] Sodium chloride 0.75%

[0043] Water for Injection 98.75%

[0044] The method of use is as follows: about half an hour before use, firmly hold the chamber 2, press the liquid medicine chamber 2 to peel off the weak sealing layer 3 separating each chamber, and mix the powder and liquid medicine. After about half an hour, the chitosan powder is completely dissolved in water for injection and can be used.

Embodiment 2

[0046] Such as figure 1 As shown, it is a ready-to-fit double chamber bag. The double-chamber bag is a non-PVC soft bag, and the non-PVC soft bag is divided into a chamber 1 and a chamber 2 with a weak sealing layer 3 in the middle. The water-soluble chitosan powder is packaged in the chamber 1, and the Water for Injection Containing Sodium Chloride.

[0047] Raw material: carboxymethyl chitosan 0.5%

[0048] Sodium chloride 0.75%

[0049] Water for Injection 98.75%

Embodiment 3

[0051] Such as figure 1 As shown, it is a ready-to-fit double chamber bag. The double-chamber bag is a non-PVC soft bag, and the non-PVC soft bag is divided into a chamber 1 and a chamber 2 by a weak sealing layer 3 in the middle. The water-insoluble chitosan powder is packaged in the chamber 1, and the Water for injections containing mannitol.

[0052] Raw material: chitosan gluconate 0.5%

[0053] Mannitol 4%

[0054] Water for injection 95.7%

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Abstract

The invention discloses a ready-to-prepare medical haemostatic and anti-adhesive flushing fluid used in perioperative period, which pertains to polymeric biological materials with anastalsis, antisepsis and anti-adhesive effect in the surgical perioperative period. Water for injection is adopted bythe invention as a carrier, water-insoluble chitosan, water-soluble chitosan or carboxymethyl chitosan is functioned as a main material, matched with osmotic pressure regulating substance NaCl or mannitol or glycin as auxiliary material. Chitosan and water for injection, or water for injection mixed and dissolved with osmotic pressure regulating substance are respectively sealed in two chambers with soft chamber bags made from PVC films, the two chambers are separated by a weak sealing layer made through thermal sealing or gluing, and can be used only by squeezing the liquid chambers to mix two liquids. The flushing liquid can be used immediately after being prepared, which is convenient for an employment and has long preservation period; the problem that the physical and chemical properties of chitosan is unstable and can not be preserved for a long term is solved.

Description

technical field [0001] The invention relates to a perioperative flushing solution for surgery, in particular to a macromolecule biomaterial flushing solution used in perioperative surgery that can stop bleeding, antibacterial and prevent postoperative tissue adhesion. Specifically, it is a ready-to-use medical hemostatic and anti-adhesion flushing solution. Background technique [0002] Irrigate fluids are used throughout surgical procedures to irrigate open surgical wounds. The flushing solution currently used clinically is traditional normal saline, which can neither effectively antibacterial, stop bleeding, prevent tissue adhesion, promote wound healing, nor inhibit implantation metastasis due to adhesion of scattered tumor cells during surgery. CN1850108A discloses a perioperative flushing solution for surgery, which is prepared by mixing and dissolving chitosan, substances for regulating osmotic pressure and water for injection, and then packaging and storing. Its dis...

Claims

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Application Information

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IPC IPC(8): A61K31/722A61P41/00
CPCY02A50/30
Inventor 胡军佟俊太鄂云祥
Owner XUZHOU HAIERZI BIOENG CHEM
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