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Medicament ingredient on-line detection method in pharmacy procedure and on-line detection system

A detection method and drug technology, applied in the field of online detection system or online detection instrument system, to achieve the effect of speeding up detection and ensuring quality

Inactive Publication Date: 2008-08-13
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention is to overcome the shortcomings of the prior art that require manual sampling and analysis, and propose a dynamic mixer as a dilution device, so that the whole process can be carried out continuously, and can be realized according to the different requirements of different samples. The adjustment of various dilution ratios can continuously and automatically dilute samples, realize the online automatic detection of component concentrations in the pharmaceutical process, and the online detection method and online detection system that can reflect the changes of component concentrations in the pharmaceutical process in time. Or proposed a method and an online detection system for liquid samples for on-line chemical composition detection, which lay the foundation for effective control of the production process and can ensure the quality of pharmaceuticals

Method used

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  • Medicament ingredient on-line detection method in pharmacy procedure and on-line detection system
  • Medicament ingredient on-line detection method in pharmacy procedure and on-line detection system
  • Medicament ingredient on-line detection method in pharmacy procedure and on-line detection system

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] see figure 2 , the tested sample input pipeline 1 is drawn out from the production device, and the raw liquid of the sample to be tested is introduced into the detection system; the measurement calibration liquid group 2 contains the diluent for diluting the sample, the reference liquid for detection, and the calibration liquid for the instrument Various liquids such as the standard liquid and the cleaning liquid after the test are completed; each liquid enters the detection system through the liquid selection valve group 3, and the liquid selection valve group determines which liquid to input at this moment; Metering peristaltic pump group 4, in which the dilution of the set ratio can be performed by adjusting the flow rate; the measured liquid diluted according to a certain dilution ratio passes through the flow pipeline group 6 and enters the dynamic mixer group 7, and the dynamic mixer Group 7 is a precision mixing mechanism with a two-stage mixing mechanism, which...

Embodiment 2

[0081] refer to image 3 , the core of the controller is the microcontroller (μC) circuit board 5 ". The controller sends various operation instructions to the industrial computer (IPC) 10 through the human-computer interaction monitoring control terminal 11, and the industrial computer transmits the operation instructions to the micro-controller. The micro-controller (μC) circuit board outputs multiple electronic signals from the microcontroller (μC) circuit board to control the action of each component in the detection instrument system. One group of electronic signals controls the on / off of the valve in the liquid selection valve group 3, In this way, the selective input of the measured sample group 1" and the measurement and calibration liquid group 2 is realized; another group of electronic signals controls the variable-speed metering peristaltic pump group 4, and controls various speed ratios of the metering pump, thereby realizing the determination of the dilution ratio;...

Embodiment 3

[0083] The operating steps of the detection system or detection instrument system are:

[0084] 1. Prepare the reference liquid and standard liquid required for the detection process, and connect the equipment with the above-mentioned liquid storage tank and the reactor of the sample to be tested according to the measurement requirements;

[0085] 2. Turn on the power of the equipment and preheat for 15 minutes;

[0086] 3. Start the "cleaning" operation program to clean the flow system circuit of the instrument;

[0087] 4. Measure the background noise and reference data: start the "reference measurement" operation program, measure the background noise and reference data of the flow system circuit of the instrument, use it as the background parameter of the measurement, and store it in the machine;

[0088] 5. Adjust the dilution ratio: start the "sample measurement" operation program, according to the ratio requirements, send the standard solution diluted in different propo...

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Abstract

The present invention provides a method, a system or device system for examining medicine component on-line in the process of pharmacy. The present method employs electric controller, dynamic dilution mixed system and mini-type ultraviolet / visible light spectrometer to examine chemistry component. The device system main comprises valve control technique, multi-streaming precise proportional dilution technique and spectrum measuring technique. The detecting device comprises valve controller, electric controller, precision variable peristalsis pump, precision dynamic mixed device, dynamic flow-through cell, multi-join sampling pipeline and precision UV-VIS fiber spectrum detector. The detecting device on-line detects the medicine component or Chinese traditional medicine active component on-line automatically in the process of pharmacy, and provides gist for pharmacy process control and efficiency direction.

Description

technical field [0001] The present invention relates to an online detection method and an online detection system for chemical components in the production and manufacturing process, more specifically, relates to the online detection of the content of chemical components in liquid samples or the content of active components of drugs or traditional Chinese medicines in the pharmaceutical process or the process of traditional Chinese medicine pharmaceuticals The method and on-line detection system or on-line detection instrument system. Background technique [0002] In the process of industrial production, the detection and control technology of production process parameters has been widely used, and the actual values ​​of process parameters such as temperature, pressure, and flow can be obtained in a very short time, so that production managers can keep abreast of the actual process conditions of the production process. information to provide the basis and guidance for the co...

Claims

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Application Information

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IPC IPC(8): G01N21/31G01N1/38G01N35/02
Inventor 史新元乔延江张秀成艾路
Owner BEIJING UNIV OF CHINESE MEDICINE
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