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Method for determining index composition content of Qingkailing injection intermediate body and finished product

A measurement method and injection technology, applied in the direction of measuring devices, material separation, analysis of materials, etc., can solve time-consuming and other problems

Inactive Publication Date: 2008-07-30
BEIJING UNIV OF CHINESE MEDICINE
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Problems solved by technology

[0003] In order to overcome the time-consuming shortcomings of the existing detection methods and realize the on-line detection of the index components in the intermediates and finished products of Qingkailing injection, the present invention uses ultraviolet spectroscopy combined with chemometrics such as partial least squares method for analysis and data analysis. Processing, not only fast and convenient, but also accurate and reliable

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  • Method for determining index composition content of Qingkailing injection intermediate body and finished product
  • Method for determining index composition content of Qingkailing injection intermediate body and finished product
  • Method for determining index composition content of Qingkailing injection intermediate body and finished product

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Embodiment 1

[0108] Embodiment 1: the method for the content of chlorogenic acid and baicalin in Yinhuang liquid measured by ultraviolet spectrometry

[0109] Yinhuang liquid is one of the intermediates in the production process of Qingkailing injection. It is made by mixing honeysuckle water extract and baicalin aqueous solution in a certain proportion. The quality index components are chlorogenic acid and baicalin.

[0110] 1 Determination method of chlorogenic acid and baicalin in Yinhuang liquid.

[0111] 1.1 Instrument: Agilent 1100 high performance liquid chromatography (Agilent, USA), including: quaternary pump, vacuum degassing pump, autosampler, column thermostat, DAD diode array detector, HP data processing workstation;

[0112] 1.2 Reagents: Chlorogenic acid and baicalin reference substances were purchased from China National Institute of Pharmaceutical and Biological Products (batch numbers 110753-200212 and 110715-200212 respectively); Yinhuang liquid was provided by a designa...

Embodiment 2

[0237] Embodiment 2: the method for measuring geniposide and total nitrogen content in four mixed liquids by ultraviolet spectrometry:

[0238] The four mixed liquid is one of the intermediates in the production process of Qingkailing injection. It is made by mixing the hydrolyzate of mother of pearl and buffalo horn, the water extract of isatidis root and the water extract of gardenia by a certain process. The quality index component is gardenia Glycosides and total nitrogen.

[0239] 1 Determination of the content of geniposide and total nitrogen in the four-mixture:

[0240] 1.1 Instruments: Agilent 1100 high performance liquid chromatography (Agilent, USA), including: quaternary pump, vacuum degassing pump, autosampler, column thermostat, DAD diode array detector, HP data processing workstation; KDY nitrogen determination Instrument (Shanghai Ruizheng Instrument Equipment Co., Ltd.);

[0241] 1.2 Reagent: The reference substance of geniposide was purchased from China Nat...

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Abstract

The invention relates to a method for measuring index component content in a Qingkailing injection midbody and a finish product. The invention is characterized in that each index component content is measured by adopting the high performance liquid chromatography or other analysis methods; the diluted sample is scanned in full wavelength by adopting the ultraviolet spectrophotometric method; the sample is divided into two parts: a corrected collection and a verified collection. According to the ultraviolet spectroscopic data and the content of the corrected collection, the data are processed by adopting the chemometrics method; a mathematical model is established by utilizing a TQ Analyst software and a Matlab 6.5 software; the ultraviolet spectroscopic data of the verified collection sample is substituted into the mathematical model; a predicted value and a true value are compared, and the precision and the reliability of the technology are verified. The method of the invention can be used for content measurement of chlorogenic acid and baicalin in the silver yellow liquid, and the content measurement of Caryptoside and total nitrogen in the four-miscible liquid. The invention also can be used for the fast online detection of component content hereinbefore, and can be used for the content measurement and fast online detection of the Qingkailing injection midbody and the finish product.

Description

technical field [0001] The present invention relates to a rapid determination method for the content of index components in intermediates and finished products in the production process of Qingkailing injection, more specifically, it relates to an ultraviolet spectrum determination method for the content of chlorogenic acid and baicalin in Yinhuang liquid. The ultraviolet spectroscopic determination method of the content of glycosides and total nitrogen relates to the determination method of the content of chlorogenic acid and baicalin in Yinhuang liquid, an intermediate in the production process of Qingkailing injection, or the green The on-line detection method for the content of ortho acid and baicalin relates to the on-line detection method for the content of geniposide and total nitrogen in the four-mixed liquid intermediate in the production process of Qingkailing injection. Background technique [0002] Qingkailing Injection is a modern traditional Chinese medicine in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/00G06F17/00
Inventor 李娜史新元张卓勇朱向荣乔延江
Owner BEIJING UNIV OF CHINESE MEDICINE
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