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Application for preparing therapy antiarrhythmic medicament of Zacopride

A technology of arrhythmia and Zacobili, which is applied in the field of medicine and can solve problems such as arrhythmia

Inactive Publication Date: 2008-06-18
SHANXI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0032] The present invention all has certain arrhythmogenic effect in order to solve existing antiarrhythmic drugs, and has not yet found I at home and abroad so far. K1 The problem of selective agonists, providing a new use of Zacopride (Zacopride), that is, a new application in pharmaceuticals - the application of Zacopride as a drug for the preparation of arrhythmia

Method used

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  • Application for preparing therapy antiarrhythmic medicament of Zacopride
  • Application for preparing therapy antiarrhythmic medicament of Zacopride
  • Application for preparing therapy antiarrhythmic medicament of Zacopride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Embodiment 1: the influence of Zacopride (Zacopride on the ion channel current of ventricular myocytes

[0072] 1 Materials and methods:

[0073] 1.1 Experimental animals:

[0074] Healthy SD rats, male, weighing 220-260 g, were purchased from the Experimental Animal Center of Zhengzhou University, Henan.

[0075] 1.2 Drugs and reagents:

[0076] Zacopride hydrochloride was purchased from TOCRIS. Collagenase P was purchased from Bochringer Mannhein, Germany, taurine, tetraethylammonium chloride (TEA), 4-aminopyridine (4-AP), nicardipine, adenosine triphosphate Sodium salt (adenosine 5'-triphosphate disodium salt), adenosine triphosphate dipotassium salt (adenosine 5'-triphosphate dipotassium salt), adenosine triphosphate magnesium salt (adenosine 5'-triphosphatemagnesium salt), DL-aspartic acid potassium salt (DL-aspartic acid acid potassium), L-glutamic acid (L-glutamic acid), Ethylene Glycol-bis (beta-aminoethyl-ether)-N, N, N', N'-Tetra Acetate (EGTA), creatine p...

Embodiment 2

[0141] Example 2: Research on the effect of Zacopride on anti-ischemic and reperfusion arrhythmias in rats

[0142] 1 Materials and methods

[0143] 1.1 Experimental animals:

[0144] Healthy SD rats, male, weighing 220-260 g, were purchased from the Experimental Animal Center of Zhengzhou University, Henan.

[0145] 1.2 Drugs and reagents:

[0146] Zacopride hydrochloride was purchased from TOCRIS. Lidocaine hydrochloride injection was purchased from Shanghai Xudong Haipu Pharmaceutical Co., Ltd.

[0147] 1.3 Main instruments:

[0148] Rm6240 multi-channel physiological signal acquisition and processing system (Chengdu Instrument Factory); HX-200 animal ventilator (Chengdu Taimeng Technology Co., Ltd.)

[0149] 1.4 Reagent preparation:

[0150] 1.4.1 Solution preparation:

[0151] 1. Zacopride stock solution: Dissolve zacopride in deionized water to a concentration of 1 mmol / L. Dilute as needed when using. .

[0152] 2. Lidocaine stock solution (0.1g / 5ml): Take it a...

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Abstract

The invention relates to the medicine field, particularly relating to a drug for treating arrhythmia, in particular to an application of Zacopride in preparing a drug for treating the arrhythmia. The invention aims at solving the problems that the present antiarrhythmic drugs have the effect of causing arrhythmia, and IK1 selective agonist has not been discovered at home and abroad so far. The Zacopride is an IK1 selective agonist which is discovered at present for the first time and is used on an antiarrhythmic drug. Used as a drug for treating ischemia-reperfusion arrhythmia, the Zacopride has the similar effect to that of lidocaine, takes effect stably and does not obviously affect the rhythm with wide safety range. In the experiments of arrhythmia induced by ischemia-reperfusion, lidocaine can make the rhythm slower, while the Zacopride has no obvious effect; and when the dosage of the lidocaine is increased by one-third, the antiarrhythmic effect is obviously weakened, while such phenomenon occurs when the Zacopride reaches one hundred times of effective concentration.

Description

technical field [0001] The invention relates to the field of medicine, and mainly relates to a medicine for treating arrhythmia, in particular to the application of Zacopride as a medicine for treating arrhythmia. Background technique [0002] Arrhythmia refers to the abnormality of heartbeat frequency and rhythm. Arrhythmia is a common cardiovascular disease in clinical practice. Severe arrhythmia is often one of the main causes of death of patients. [0003] Myocardial ischemia, hypoxia, acidosis / alkalosis, electrolyte disturbance, drug poisoning, myocardial injury, etc. can all induce arrhythmia. The basic mechanisms of arrhythmia are reentry, abnormal automaticity and triggered activity. That is, all arrhythmias are caused by impulse conduction disorders, impulse formation disorders, or both. The mechanism of severe arrhythmia is very complicated, and it is often not a single mechanism, but at its root, there is a change in the functional activity of ion channels. Or ...

Claims

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Application Information

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IPC IPC(8): A61K31/439A61K9/08A61K9/10A61K9/127A61K9/16A61K9/48A61K9/50A61P9/06
Inventor 吴博威李晓丽刘清华杨彩红李媛封启龙白晓洁
Owner SHANXI MEDICAL UNIV
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