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Fructose diphosphate sodium particle and preparation method thereof

The technology of sodium fructose diphosphate and granules is applied in the field of pharmaceutical preparations for the treatment of cardiovascular and cerebrovascular diseases and the field of preparation thereof, which can solve the problems of bad taste, slow absorption, difficult for patients to accept, etc. receptive effect

Inactive Publication Date: 2008-06-04
何晶
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the oral dosage forms of sodium fructose diphosphate currently on the market have the disadvantages of slow absorption and bad taste, and are not easily accepted by patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: prepare the prescription and consumption of 1000 bags

[0026] Sodium fructose diphosphate 1000.0g (in C 6 h 11 Na 3 o 12 P 2 count)

[0027] Mannitol 1500.0g

[0028] Polyvinylpyrrolidone K-30 60.0g

[0029] Aspartame 15.0g

[0030] Citric acid 30.0g

[0031] Lemon essence 15ml

[0032] Preparation process: After pulverizing sodium fructose diphosphate, pass through a 100-mesh sieve; the auxiliary materials mannitol, citric acid and aspartame pass through a 80-mesh sieve respectively, and set aside; weigh polyvinylpyrrolidone K-30, and prepare it with 75% ethanol solution Make a solution with a concentration of 5% for later use; firstly mix citric acid and aspartame evenly, then mix evenly with mannitol by an equal amount incremental method, then add sodium fructose diphosphate and mix evenly, and then add the prepared adhesive , made into soft materials, granulated with a 20-mesh sieve; the granules were dried at 40°C-50°C for 3-4 hours, sized ...

Embodiment 2

[0033] Embodiment 2: Prescription and consumption of preparing 1000 bags

[0034] Sodium fructose diphosphate 1000.0g (in C 6 h 11 Na 3 o 12 P 2 count)

[0035] Microcrystalline Cellulose 1500.0g

[0036] Ethyl cellulose 60.0g

[0037] Stevioside 20.0g

[0038] Citric acid 25.0g

[0039] Orange Flavor 15ml

[0040] Preparation process: After pulverizing sodium fructose diphosphate, pass through a 100-mesh sieve; the excipients mannitol, citric acid and aspartame pass through a 80-mesh sieve respectively, set aside, weigh ethyl cellulose, and prepare 50-mesh sieve with 75% ethanol solution % concentration of the solution for subsequent use; firstly mix citric acid and stevioside evenly, then mix evenly with microcrystalline cellulose by an equal amount incremental method, then add sodium fructose diphosphate and mix evenly, then add the prepared binder to prepare Make soft material, granulate with 20-mesh sieve; dry the granules at 40°C-50°C for 3-4 hours, sieve with ...

Embodiment 3

[0041] Embodiment 3: Prescription and consumption of preparing 1000 bags

[0042] Sodium fructose diphosphate 1000.0g (in C 6 h 11 Na 3 o 12 P 2 count)

[0043] Compressible starch 1500.0g

[0044] Polyvinylpyrrolidone K 30 60.0g

[0045] Aspartame 15.0g

[0046] Citric acid 30.0g

[0047] Lemon essence 15ml

[0048] Preparation process: crush sodium fructose diphosphate and pass through a 100-mesh sieve; excipients compressible starch, citric acid and aspartame pass through a 80-mesh sieve for later use; weigh polyvinylpyrrolidone K 30 , mixed with water to make a solution with a concentration of 5% for later use; firstly mix citric acid and aspartame evenly, then mix evenly with mannitol by an equal amount incremental method, then add sodium fructose diphosphate and mix evenly, and then add the prepared The binder is made into soft materials, granulated with a 20-mesh sieve; the granules are dried at 40°C-50°C for 3-4 hours, granulated with a 14-mesh sieve, a...

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Abstract

The invention provides a fructose diphosphate sodium granule and a preparation of the fructose diphosphate sodium granule. The fructose diphosphate sodium granule of the invention comprises effective amount of fructose diphosphate sodium and medical subsidiary substances. The medical subsidiary substances comprise thinner, bond and flavoring agent; wherein, the thinner can be one or a plurality of substances among amylum pregelatinisatum, lactose, crystallite fibrin or mannitol; the bond is one or a plurality of substances among polyvinylpyrrolidone K30, ethyl cellulose or hydroxypropyl methyl cellulose; the flavoring agent is one or a plurality of substances among aspartame, citric acid, stevioside, lemon essence or orange essence. And the weight ratio of the medical subsidiary substances is: the fructose diphosphate sodium: the thinner: the bond: the flavoring agent is equal to 100: 30 to 200: 1 to 30:1 to 30. The invention also provides the preparation method of the fructose diphosphate sodium granule. The invention has the advantages that medicine-taking is convenient; the manufacturing cost is low; special equipment are not needed; taking and delivering are convenient and stable, etc.

Description

technical field [0001] The invention relates to an improved pharmaceutical dosage form of sodium fructose diphosphate, and provides a pharmaceutical preparation for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. Background technique [0002] Sodium fructose diphosphate (FDP) is a biologically active biochemical product, which is a biochemically active substance in the glucose metabolism and energy metabolism of human tissue cells. In its molecular structure, there are two biological high-energy phosphate bonds, which can effectively provide biological energy and promote the metabolic activities of biological tissue cells. It can regulate the activity of various enzyme systems in glucose metabolism. Exogenous sodium fructose diphosphate can activate the activity of phosphofructokinase and pyruvate kinase, increase the concentration of ATP in cells, promote the influx of potassium ions, and benefit the energy metabolism of cells and the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/6615A61P9/00
Inventor 何晶
Owner 何晶
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