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Proprietary Chinese medicine for treating diabetes and nephrosis and preparing method thereof

A technology of diabetic nephropathy and Chinese patent medicine, which is applied in the direction of medical formulas, urinary system diseases, medical preparations containing active ingredients, etc., can solve the problems of side effects, different curative effects, and few basic experimental studies of western medicines, so as to facilitate long-term use , clear pharmacological action and reliable curative effect

Active Publication Date: 2008-04-30
SHANDONG PHOENIX PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above reports are some clinical trial studies, one medicine or decoction addition and subtraction, or even the combination of traditional Chinese medicine and western medicine, the curative effect is different, the reproducibility is not good, and there are few basic experimental studies
Diabetic nephropathy is a chronic disease, and most western medicines have side effects or addiction. At present, there is no Chinese patent medicine for the treatment of diabetic nephropathy. The development and research of a Chinese patent medicine for the treatment of diabetic nephropathy will surely have a large market space and a huge social impact. benefit

Method used

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  • Proprietary Chinese medicine for treating diabetes and nephrosis and preparing method thereof
  • Proprietary Chinese medicine for treating diabetes and nephrosis and preparing method thereof
  • Proprietary Chinese medicine for treating diabetes and nephrosis and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0142] [Example 1] Preparation of capsules of the drug of the present invention

[0143] The preparation method includes the following steps:

[0144] (1) According to the weight ratio in Table 27, the Astragalus, Rehmannia glutinosa, Ligustrum lucidum, Rhubarb (processed product), Gymnema leaves, Cyclobalanopsis sylvestris and Psyllium spp. raw materials are refluxed with 85% ethanol. Extract 3 times, the extraction time is 3.5 hours, the obtained extract is filtered to remove the drug residue, the filtrate is combined, and the filtrate is reduced to recover ethanol and concentrated to an extract with a relative density of 1.18 to 1.35 (temperature 40°C), and the resulting concentration Dissolve the substance in water and place it to settle for 30 hours at room temperature (20°C) to obtain a precipitate;

[0145] (2) Take the supernatant after precipitation and pass D 101 After the large-porous adsorption resin column, it is eluted with 90% ethanol, and the elution is repeated se...

Embodiment 2

[0148] [Example 2] Preparation of capsules of the drug of the present invention

[0149] In the preparation method: the weight ratio of each raw material is according to Table 27; the ethanol concentration in the ethanol reflux extraction is 75%, the reflux extraction is 4 times, and the extraction time is 2.5 hours. The extracted filtrate is concentrated into a thin film concentration, at room temperature The settling time is 40 hours; after passing through the D101 type macroporous adsorption resin column, it is eluted with 80% ethanol; adding water to decoct 3 times, the amount of water added is 7 times the amount of crude medicinal materials, and the decoction time is 3 hours; Combine the precipitate, Concentrate A and Concentrate B, add appropriate amount of silica, dry at 80°C for 2 days, pulverize and pass through a 60-mesh sieve; add appropriate amount of sodium carboxymethyl starch; the rest are the same as in Example 1.

Embodiment 3

[0150] [Example 3] Preparation of capsules of the drug of the present invention

[0151] In the preparation method: the weight ratio of each API is in accordance with Table 27; the ethanol concentration in the ethanol reflux extraction is 70%, the reflux extraction is performed twice, and the extraction time is 4 hours. The extracted filtrate is concentrated to vacuum concentration and placed at room temperature Settling time is 35 hours; pass D 101 The macroporous adsorption resin column is eluted with ethanol with a concentration of 85%; add water to decoct twice, the amount of water added is 8 times the amount of crude medicinal materials, and the decoction time is 4 hours; combine the precipitate, concentrate A and concentrate B Then add appropriate amount of silicon dioxide, dry at 80° C. for 1 day, pulverize and pass through a 20-mesh sieve; add appropriate amount of sodium carboxymethyl starch; the rest are the same as in Example 1.

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Abstract

The invention provides a Chinese patent medicament for treating diabetic nephropathy, which is prepared by raw medicines with following part by weight, 135-680 parts of astragalus, 159-485 parts of ligustrum japonicum, 23-112 parts of leeches, 95-350 parts of batryticated silkworm, 15-113 parts of ground beetle, 74-397 parts of rhubarb horsetails, 232-985 parts of gymnema sylvestre, 245-820 parts of orientavine, and 210-615 parts of plantain seed. The invention provides a Chinese patent drug for treating diabetic nephropathy, which has reliable efficacy and no obvious toxic and side effect, and is convenient for long-term administration.

Description

[Technical Field] [0001] The invention relates to a Chinese patent medicine for treating diabetic nephropathy and a preparation method thereof. [Background technique] [0002] Diabetic Nephro Pathy (Diabetic Nephro Pathy) is abbreviated as DN (the same below), which is a glomerular disease dominated by vascular damage. DN is one of the most serious and common chronic complications of diabetes. Its incidence is reported by foreign countries. Up to 4.5%. About 1 / 3 insulin-dependent diabetes mellitus and 1 / 5 non-insulin-dependent diabetes mellitus eventually develop into DN. After 10-19 years of diabetic patients, 53% of patients with DN die of renal failure, and the mortality rate is already in tumor, cardiovascular and cerebrovascular Third place after illness. Once diabetic patients develop nephropathy and persistent urinary protein, the condition is irreversible, and it often progresses to renal failure, which is one of the main causes of death in diabetic patients. So far, ther...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K9/20A61K9/48A61P3/10A61P13/12A61K35/62A61K35/64
Inventor 钟国跃梁旭明张莉唐耀书蒋渝黄贞明王天文
Owner SHANDONG PHOENIX PHARM CO LTD
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