Terbinafine or its salt film forming gel composition and uses thereof

Abstract

The present invention discloses a compound of an Terbinafine or the halo-Terbinafine membrane forming gel, which comprises the components of the following weight percentages comprising 0.5 percentage to 7 percentage of alkyl cellulose, 1 percentage to 10 percentage of etherifying agent, 0.5 percentage to 5 percentage of cross linking agent, 0.5 percentage to 5 percentage of accentuator, 75 percentage to 90 percentage of dissolvant0.1 percentage to 5 percentage, of Terbinafine or the halo-Terbinafine. The cross linking agent is the saturated fat or the alcoholic acid, the chemical general formula of which is CnH2n+2-m-l(OH)m(COOH)l. Among the formula, m or n or 1 is the integer and the n is no less than m, which is no less than 2. 1 is no less than 0 and the result of m plus 1 is 4 to 8. The result of n plus 1 is 4 to 8. In the present invention, the compound of the Terbinafine or the halo-Terbinafine local membrane forming gel is applied for treatment of the local fungus inflammation. A water drain protective membrane with smooth property, firm property, wear-resisting property and duration property is formed on the surface of the ulcer when the present invention is applied. Compared with all kinds of formulations of the Terbinafine or the halo-Terbinafine in the present technique, the membrane formed by the gel compound is not likely to experience fracture, dissolution or corrosion. The membrane has the properties of long maintenance time and slow releasing of the medicine.

Description

technical field [0001] The invention relates to a film-forming gel composition of terbinafine or its salt and its application in the preparation of medicine for treating local fungal inflammation of the body. Background technique [0002] Skin ringworm caused by fungal local infection, such as athlete's foot, tinea corporis, jock itch, etc., is a common disease that people often encounter in daily life. The local pharmaceutical preparations used to treat these diseases are usually creams and ointments. , gels, sprays, liniments, etc., such as preparations with terbinafine hydrochloride as the active ingredient. Wherein, terbinafine (Terbinafine) and its salt, such as its hydrochloride (Terbinafine Hydrochloride) are a class of allylamines with broad-spectrum antifungal activity, can specifically interfere with the early biosynthesis of fungal sterols, and have high selectivity Inhibit the ersqualene epoxidase of fungi, so that the epoxidation reaction of ersqualene in the p...

AI Technical Summary

Problems solved by technology

However, we have found that the local film-forming gel composition made of monoglyceryl laurate as a cross-linking agent, although the flexibility of the film is enhanced, the time of adhesion to body tissues or mucous membranes is relatively short, as in The film formed on the oral mucosa is easily eroded / dissolved by body fluids or saliva, causing the film to rupture prematurely, fall off, and even disappear, and its effective residence time on the oral mucosa is only 3 to 4 hours

[0006] Therefore, as adopting the technology of above-mentioned existing film-forming gel composition to prepare terbinafine or its salt film-forming gel composition, then the medicine wherein and affected part keep time is shorter, influence curative effect

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