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Antibiotic compound containing beta-lactam antibiotic and buffering component

A technology of lactams and antibiotics is applied in the field of antibiotic compound composed of buffer components, which can solve the problems of reducing titer and the like

Active Publication Date: 2008-02-27
ガンゾウ ヘメイ ファーマスーティカル カンパニー リミテッド
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since β-lactam antibiotics are acidic compounds, and aminoglycoside antibiotics are alkaline substances, when these two types of antibiotics are used together in the same container, they will form a precipitate due to the formation of salt, or aminoglycoside antibiotics will Amino groups react with the β-lactam in β-lactam antibiotics to greatly reduce the potency of the two. Therefore, it is generally forbidden to use these two types of antibiotic solution preparations in the same container clinically.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0457] Recipe: cefoperazone sodium 4g, gentamicin 80mg / 2mL injection.

[0458] Preparation method: Dissolve cefoperazone sodium in 200mL water for injection, add gentamicin injection, and a large amount of white precipitate will be produced immediately.

Embodiment 2

[0460] Dissolve 40 mg of cefoperazone sodium in 2 mL of various buffer solutions with different pH values ​​and strengths, and drop into 20 μL of gentamicin 80 mg / 2 mL injection. Sonicate for 5 minutes to observe whether there is precipitation. The result is that no precipitation is formed when the pH value of the buffer is above 6, and a clear solution can be obtained. The type of buffer has little effect on the result. The results are shown in the table below.

[0461] Type of buffer

[0462] * The solution becomes slightly cloudy ** the solution becomes cloudy *** The solution is cloudy OK: clear liquid.

Embodiment 3

[0464] Dissolve 40 mg of cefoperazone sodium and 5 mg of sulbactam sodium in 2 mL of various buffer solutions with different pH values ​​and strengths, and drop into 20 μL of gentamicin 80 mg / 2 mL injection. Sonicate for 5 minutes to observe whether there is precipitation. The result is that there is no precipitation when the pH value of the buffer is above 6 and the strength is above 20mM, and a clear solution can be obtained. The type of buffer has little effect on the result. The results are shown in the table below.

[0465] Type of buffer

[0466] * The solution becomes slightly cloudy ** the solution becomes cloudy *** The solution is cloudy OK: clear liquid.

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PUM

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Abstract

The invention discloses an antibiotic compound, which comprises the following parts: at least one beta-lactam antibiotics and at least one buffer compound, at least one beta-lactamase inhibitor. The invention can build with at least one aminoglycoside antibiotics in the same container into solution, which can control biologically infectious drug of microbe.

Description

Field of invention: [0001] The invention discloses an antibiotic composition comprising at least one β-lactam antibiotic and at least one buffer component. The composition can be further added with at least one β-lactamase inhibitor, or can be combined with at least one aminoglycoside Antibiotics or at least one β-lactamase inhibitor and at least one aminoglycoside antibiotics are mixed together in the same container to form a solution preparation, which is used as a drug for controlling microbial infection. technical background: [0002] β-lactam antibiotics inhibit bacterial cell wall synthesis by inhibiting the activity of D-alanyl-D-alanine transpeptidase (Peptidoglycan transpeptidase) in bacteria. Because mucopeptides are some sugar-containing polypeptides with a network structure, they are composed of N-acetylglucosamine (Glc-NAc) and N-acetylmuramic acid (Mur-NAc) alternately composed of linear glycan chain short peptides, these The high polymer needs to undergo a tr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/545A61K31/43A61K31/7036A61K47/18A61K9/08A61K9/19A61P31/04
CPCA61K31/7036A61K47/02A61K9/19A61K47/26A61K31/546A61K31/43A61K31/431A61K45/06A61K9/0019A61K31/00A61K31/545A61K47/12A61K31/424A61K47/183A61P31/00A61P31/04A61P43/00A61K2300/00
Inventor 张和胜
Owner ガンゾウ ヘメイ ファーマスーティカル カンパニー リミテッド
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