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Antibiotic compound containing beta-lactam antibiotic and ion chelating agent

An ion chelating agent and lactam technology, which can be used in medical preparations containing active ingredients, antibacterial drugs, drug combinations, etc., and can solve the problems of unstable solution and excessive particle formation.

Inactive Publication Date: 2008-02-27
GANZHOU HEMAY PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] One problem with the formulation of solutions of β-lactam antibiotics is that the solutions are not very stable at room temperature, and unstable solutions tend to produce particles, especially when frozen solutions of β-lactam antibiotics are rethawed or prepared as lyophilized When the β-lactam antibiotic preparation for powder injection is reconstituted into a solution, and the longer it is left, the more particles are formed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0479] Recipe: cefoperazone sodium 4g, gentamicin 80mg / 2mL injection.

[0480] Preparation method: add gentamicin injection to 200mL water for injection of cefoperazone sodium, and a large amount of white precipitate will be produced immediately.

Embodiment 2

[0482] Dissolve 40 mg of cefoperazone sodium and 0.01 mg of disodium EDTA in 2 mL of buffer solutions of various pH values ​​and strengths, and drop into 20 μL of gentamicin 80 mg / 2 mL injection. Sonicate for 5 minutes to observe whether there is precipitation. The result is that no precipitation is formed when the pH value of the buffer is above 6, and a clear solution can be obtained. The type of buffer has little effect on the result. The results are shown in the table below.

[0483] Type of buffer

[0484] * The solution becomes slightly cloudy ** the solution becomes cloudy *** The solution is cloudy OK: clear liquid.

Embodiment 3

[0486] Dissolve 40 mg of cefoperazone sodium, 0.01 mg of disodium EDTA and 10 mg of sulbactam sodium in 2 mL of various buffer solutions with different pH values ​​and strengths, and drop into 20 μL of gentamicin 80 mg / 2 mL injection. Sonicate for 5 minutes to observe whether there is precipitation. The result is that there is no precipitation when the pH value of the buffer is above 6 and the strength is above 20mM, and a clear solution can be obtained. The type of buffer has little effect on the result. The results are shown in the table.

[0487] Type of buffer

[0488] * The solution becomes slightly cloudy ** the solution becomes cloudy *** The solution is cloudy OK: clear liquid.

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PUM

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Abstract

The invention discloses an antibiotic compound, which comprises the following parts: at least one beta-lactam antibiotics and at least one ion chelant to inhibit the generation of particle or at least one buffer component or at least one ion chelant and at least one buffer component. The compound can build with at least one aminoglycoside antibiotics in the same container as the drug to control microbe infection.

Description

Field of invention: [0001] The invention discloses an antibiotic composition comprising at least one β-lactam antibiotic and at least one ion chelating agent capable of inhibiting particle formation. The composition can further add at least one β-lactamase inhibitor or buffer component, Or add at least one β-lactamase inhibitor and buffer components at the same time; the characteristic of this compound is that it can be made into a stable solution preparation, and it can also be compounded into a solution preparation with at least one aminoglycoside antibiotic in the same container It is used as a drug for controlling microbial infection; the compound can also be compounded into a solution preparation by adding β-lactamase inhibitors, aminoglycoside antibiotics and buffer components at the same time and used as an antimicrobial infection drug. technical background: [0002] Cephalosporin (Cephalosporin) is derived from Cephalosporin acremonium, of which cephalosporin C has a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/545A61K31/43A61K31/7036A61K47/18A61K9/08A61K9/19A61P31/04
CPCA61K9/0019A61K31/7036A61K9/19A61K31/545A61K47/26A61K31/546A61K47/12A61K31/424A61K47/46A61K31/43A61K47/183A61P31/00A61P31/04A61P43/00
Inventor 张和胜
Owner GANZHOU HEMAY PHARM CO LTD
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