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Pharmaceutical composition containing amoxicillin, ambroxol and beta lactamase restrainer and uses thereof

A β-lactamase and amoxicillin technology, applied in the field of medicine, can solve problems such as failure to provide amoxicillin, and achieve the effect of solving the problem of drug resistance, shortening the course of disease, and strengthening the results of treatment

Inactive Publication Date: 2008-02-27
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing amoxicillin / ambroxol products and technologies fail to provide a good means to solve or deal with the problem of amoxicillin resistance, so as to give full play to the role of amoxicillin / ambroxol in the treatment of respiratory diseases

Method used

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  • Pharmaceutical composition containing amoxicillin, ambroxol and beta lactamase restrainer and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 Amoxicillin+potassium clavulanate+ambroxol hydrochloride tablets, each containing 250 mg of amoxicillin, 125 mg of clavulanic acid and 15 mg of ambroxol hydrochloride, 1000 tablets were prepared in total.

[0019] Amoxicillin 250g

[0020] Potassium clavulanate 125g (calculated as clavulanic acid)

[0021] Ambroxol Hydrochloride 15g

[0022] Microcrystalline Cellulose 70g

[0023] Micronized silica gel 10g

[0024] Croscarmellose Sodium 6g

[0025] Magnesium Stearate 9g

[0026]

[0027] Made into 1000 pieces

[0028] Preparation method: Take the prescribed amount of amoxicillin powder, potassium clavulanate powder and ambroxol hydrochloride powder and mix evenly, dry each auxiliary material separately and pass through a 100-mesh sieve, and add various auxiliary materials to three components according to the method of increasing in equal amounts In the mixed powder, the powder is directly com...

Embodiment 2

[0029] Example 2 Amoxicillin + clavulanic acid + ambroxol tablets, each containing 250 mg of amoxicillin, 62.5 mg of clavulanic acid and 15 mg of ambroxol, and a total of 1000 tablets were prepared.

[0030] Amoxicillin 250g

[0031] Clavulanate 62.5g

[0032] Ambroxol 15g

[0033] Microcrystalline Cellulose 50g

[0034] Micronized silica gel 8g

[0035] Croscarmellose Sodium 4g

[0036] Magnesium Stearate 6g

[0037]

[0038] Made into 1000 pieces

[0039] Preparation method: Take the prescribed amount of amoxicillin powder, clavulanic acid powder and ambroxol powder and mix evenly, dry each auxiliary material separately and pass through a 100-mesh sieve, and put various auxiliary materials and three-component mixed powder on a dry extrusion granulator Dry pressing into granules, tableting and coating.

Embodiment 3

[0040] Example 3 Amoxicillin sodium + potassium clavulanate + ambroxol hydrochloride capsules, each containing 250 mg of amoxicillin, 125 mg of clavulanic acid and 15 mg of ambroxol hydrochloride, 1000 capsules were prepared in total.

[0041] Amoxicillin sodium 250g (calculated as amoxicillin)

[0042] Potassium clavulanate 125g (calculated as clavulanic acid)

[0043] Ambroxol Hydrochloride 15g

[0044] Microcrystalline Cellulose 70g

[0045] Micronized silica gel 10g

[0046] Croscarmellose Sodium 6g

[0047] Magnesium Stearate 9g

[0048]

[0049] Make 1000 capsules

[0050] Preparation method: Take the prescribed amount of amoxicillin sodium powder, potassium clavulanate powder and ambroxol hydrochloride powder and mix evenly, dry each auxiliary material separately and pass through a 100-mesh sieve, and dry extrude the various auxiliary materials and the three-component mixed powder Dry press on a type gra...

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PUM

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Abstract

The invention discloses a drug composition, which comprises the following parts: Amoxicillin with effective drug dosage or Amoxicillin sodium salt and beta-lactamase inhibitor and hydrobromic suo or hydrobromic suo alcaine. The invention reinforces the treating effect within short path to possess precise dosage and convenient clinic usage, which can treat acute bronchitis, asthmatic bronchitis, acute paroxysm of chronic bronchitis, bronchial expansion and bronchial asthma, otitis media, pharyngitis, nasal sinusitis, pneumococcosis and tonsillitis.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing amoxicillin, ambroxol and a beta-lactamase inhibitor and its application in the preparation of medicines for treating respiratory diseases, otitis media or tonsillitis. Background technique [0002] Respiratory diseases such as acute bronchitis, asthmatic bronchitis, acute exacerbation of chronic bronchitis, bronchiectasis and bronchial asthma, as well as otitis media, pharyngitis, sinusitis, pneumonia and tonsillitis, are common multiple diseases. The morbidity and mortality are both on the rise. The common symptoms are cough, sputum, or accompanied by shortness of breath, wheezing, etc. In severe cases, emphysema and cor pulmonale may occur. Among them, cough, wheezing, phlegm, and inflammation symptoms often exist at the same time and are mutually causal. Clinically, expectorants and antibacterial drugs are often used in com...

Claims

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Application Information

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IPC IPC(8): A61K31/43A61K31/431A61K45/06A61P11/04A61P11/00A61P27/16A61K31/424
Inventor 周利娟陈亚军秦汉陵颜锵
Owner 颜锵
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