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Controlled-release formulation containing tamsulosin hydrochloride

A technology of controlled-release preparations and sorosin, which can be used in pill delivery, coating, capsule delivery, etc., and can solve the problems of cost-effectiveness and complicated process

Inactive Publication Date: 2008-02-20
CTC BIO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the process of producing such granular formulations by granulating and coating these granules is complicated, not cost-effective, and requires special equipment to coat the granules

Method used

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  • Controlled-release formulation containing tamsulosin hydrochloride

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Embodiment Construction

[0041] Hereinafter, preferred embodiments of the present invention will be described in detail. Before the description, it should be understood that various changes can be made to the present invention, and it should be understood that the scope of the present invention is not limited to the following embodiments.

[0042] The production of embodiment 1-4 and comparative example 1-4

[0043] Examples and comparative examples were produced with the components and contents shown in Table 1 below. Almost 10,000 tablets were prepared at one time in each example. That is, 10,000 times the weight of each component was measured to prepare each formulation. For example, the production method of Example 1 is as follows: 2 g of tamsulosin hydrochloride and 50 g of polyvinylpyrrolidone are dissolved in 600 ml of ethanol to prepare a binding solution. The binding solution was combined with 936 g of lactose and 530 g of microcrystalline cellulose to form granules. These granules were d...

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Abstract

The present invention relates to a controlled-release preparation containing tamsulosin hydrochloride. The preparation of the present invention can release tamsulosin hydrochloride at zero-order rate regardless of ambient conditions of stomach and small intestine, and therefore can reduce several side effects and maintain the effect of the drug constantly. In addition, the tamsulosin hydrochloride-containing controlled-release preparation of the present invention is simple to manufacture and cost-effective, and can be made with conventional tabletting machine and coating machine used usually so that it does not need a specific equipment.

Description

technical field [0001] The present invention relates to a controlled-release preparation containing tamsulosin hydrochloride, more specifically, the present invention relates to a controlled-release preparation capable of releasing tamsulosin hydrochloride at a zero-order rate regardless of the environmental conditions in the body preparation. Background technique [0002] Tamsulosin hydrochloride is an alpha-1 blocker selective for prostate smooth muscle. Tamsulosin hydrochloride is a drug that has a therapeutic effect on urinary tract obstructive lesions caused by benign prostatic hyperplasia. The daily dose of tamsulosin hydrochloride is usually 0.2-0.8 mg. Unlike other α-1 blockers such as doxazosin and terazosin, tamsulosin hydrochloride has higher selectivity to prostate smooth muscle and weak effect on blood vessels, thus greatly Reduced occurrence of side effects such as orthostatic hypotension. Although tamsulosin hydrochloride is highly selective for prostate s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22
CPCA61K9/2866A61K9/2846A61K9/20A61K9/48A61K31/18
Inventor 全泓烈权度又李凤相
Owner CTC BIO INC
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