Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Wet granulation technology for cefuroxime axetil tablets

A technology of cefuroxime axetil and furoxetin tablets, which is applied in the field of wet granulation technology of cefuroxime axetil tablets, which can solve the problems of high requirements for excipients, high production costs, and the need for special equipment

Inactive Publication Date: 2008-02-13
JIANGSU QINGJIANG PHARMA
View PDF0 Cites 17 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dry granulation or full powder tableting, first, the requirements for excipients are too high, and most of the excipients need to be imported; second, the requirements for equipment are high, and special equipment is needed; third, in the preparation process, the first pass rate is low, high production cost

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0009] Example 1: The wet granulation process of cefuroxime axetil tablet of the present invention consists of the following steps: first, take 163 grams of cefuroxime axetil, 25 grams of sodium carboxymethyl starch, 75 grams of starch, and 10 grams of lactose through 60 mesh Sieve and mix evenly; then, add 20 grams of micropowder silica gel, mix evenly; secondly, add 100ml of 2% hydroxypropyl methylcellulose to make soft material, granulate with a 16-mesh nylon screen, dry at 60°C for 5 hours, and 14-mesh nylon Sieve granulation; then, add 25 grams of sodium carboxymethyl starch, 5 grams of magnesium stearate, mix well, press the tablet core containing 125 mg of cefuroxime axetil in each tablet; finally, press the conventional film coating tablet core, wrap The coating solution is sprayed at a slow speed, and the tablet cores are dried at any time at 40°C, wherein the coating solution for 1000 tablet cores is 100ml of 20% pharmaceutical film coating premix.

[0010] The table...

example 2

[0011] Example 2: The wet granulation process of cefuroxime axetil tablet of the present invention consists of the following steps: first, take 163 grams of cefuroxime axetil, 25 grams of sodium carboxymethyl starch, 75 grams of starch, and 10 grams of lactose through 60 mesh Sieve and mix evenly; then, add 20 grams of micropowdered silica gel, mix evenly; secondly, add 100ml of 2% hydroxypropyl methylcellulose to make soft material, granulate with a 16-mesh nylon screen, dry at 60°C for 5.5 hours, and 14-mesh nylon Sieve granulation; then, add 25 grams of sodium carboxymethyl starch, 5 grams of magnesium stearate, mix well, press the tablet core containing 125 mg of cefuroxime axetil in each tablet; finally, press the conventional film coating tablet core, wrap The coating liquid is sprayed at a slow speed, and the tablet cores are dried at any time at 45° C., wherein the coating liquid for 1000 tablet cores is 100 ml of 20% pharmaceutical film coating premix.

[0012] The ta...

example 3

[0013] Example 3: The wet granulation process of cefuroxime axetil tablet of the present invention consists of the following steps: first, weigh 163 grams of cefuroxime axetil, 25 grams of sodium carboxymethyl starch, 75 grams of starch, and 10 grams of lactose through 60 mesh Sieve and mix evenly; then, add 20 grams of micropowder silica gel, mix evenly; secondly, add 100ml of 2% hydroxypropyl methylcellulose to make soft material, granulate with 16-mesh nylon sieve, dry at 60°C for 6 hours, and 14-mesh nylon Sieve granulation; then, add 25 grams of sodium carboxymethyl starch, 5 grams of magnesium stearate, mix well, press the tablet core containing 125 mg of cefuroxime axetil in each tablet; finally, press the conventional film coating tablet core, wrap The coating liquid is sprayed at a slow speed, and the tablet cores are dried at any time at 50° C., wherein the coating liquid for 1000 tablet cores is 100 ml of 20% pharmaceutical film coating premix.

[0014] The tablet p...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Hardnessaaaaaaaaaa
Hardnessaaaaaaaaaa
Hardnessaaaaaaaaaa
Login to View More

Abstract

The present invention discloses a wet particle process for a cefuroxime axetil tablet. Firstly, 163g cefuroxime axetil, 25g carboxyl methyl starch sodium, 75g starch and 10g lactoseare are selected, followed by crossing the screen with 60 holes and mixing . Secondly, 20g silica gel particle is added and well mixed. Thirdly, 100ml hydroxypropyl methylcellulose of 2 percent is produced into the flexible material and particles are produced by a nylon screen with 16 holes. The product is dried at 60 DEG C for 5 to 6 hours and the particles are selected by a nylon screen with 14 holes. Followed by homogeneous mixing of 25g carboxyl methyl starch sodium, 5g magnesium separate and tabletting the core by 125mg cefuroxime axetil per tablet. Finally, the packaging liquid can spray slowly and the tablet core is dried at 40 DEG CC to 50 DEG C at any time. The packaging liquid for 1000 tablet cores is 100ml pharmaceutical film coating premixed agent of 20 percent. In the wet particle process of the present invention, the carboxymethyl sodium particle is added by internal and external addition. Therefore the tablet core is quickly divided into particles and further divided into thin powder, and then the biological activity is released quickly.

Description

technical field [0001] The invention relates to a wet granulation process of medicines, in particular to a wet granulation process of cefuroxime axetil tablets. Background technique [0002] Cefuroxime axefil (ceftin) is also known as cefuroxime tetrazole formic acid ester, cefuroxime axetil. It is a second-generation semi-synthetic cephalosporin created by British GlaxoSmithKline. The drug has a high concentration, can penetrate into sputum, bone tissue and inflammatory cerebrospinal fluid, has little nephrotoxicity, and can be administered orally. Launched by Glaxo-Wellcome in 1988, the trade name is CEFTIN. The drug is hydrolyzed in vivo to release cefuroxime to exert its antibacterial activity, and its in vitro sterility is related to its combination with several key targeting proteins to inhibit the synthesis of cell walls. Cefuroxime axetil has bactericidal activity against a variety of common pathogens, and is stable to a variety of bacterial β-lactamases, especial...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/20A61K9/28A61K31/546A61P31/04
Inventor 滕奇顾海成吴朝兵
Owner JIANGSU QINGJIANG PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com