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Self-degradable two-component reactive adhesive for medical use and resin for medical use

A reactive adhesive, medical technology, applied in adhesive types, protein adhesives, polysaccharide adhesives, etc., can solve the problems of difficult bonding, difficult handling, high viscosity, etc., and achieve excellent adhesion Effect

Active Publication Date: 2008-01-23
BERTELSMANN MUSIC GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this adhesive has the disadvantages of being difficult to handle due to its high viscosity, and difficult to adhere to parts with a lot of blood and body fluids.

Method used

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  • Self-degradable two-component reactive adhesive for medical use and resin for medical use
  • Self-degradable two-component reactive adhesive for medical use and resin for medical use
  • Self-degradable two-component reactive adhesive for medical use and resin for medical use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0102] 1. The control of the amount of aldehyde group introduced by sodium periodate

[0103] 5 g of dextran with a weight average molecular weight of 200,000 (Wako Pure Chemical Industries, Ltd., batch number: EWN0778) was dissolved in 100 ml of distilled water. Next, various amounts of sodium periodate (molecular weight: 213.89) were added and reacted while stirring at 40° C. for 5 hours. Then, the solution after the reaction was dialyzed against distilled water for 24 hours (using a dialysis membrane with a molecular weight of 14,000), and then freeze-dried. Aldehydated dextran is thus obtained.

[0104] For each of the obtained hydroformylated dextran, the amount of introduced aldehyde groups was measured. Then, the relationship between the added amount (mol) of sodium periodate relative to the sugar residue amount (mol) of dextran and the amount (mol) of aldehyde group introduction was obtained. The result is shown in Figure 1.

[0105] In addition, the measurement of...

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Abstract

The invention provides a medical adhesive and a medical hydrogel resin, which can fully meet the general properties required by the medical adhesive or resin, and can quickly disintegrate after a set disintegration time. disintegration, and can adjust and control the setting time relatively freely. An aqueous solution of hydroformylated α-glucan having a weight-average molecular weight of 1,000 to 200,000 is used as the first solution, and an aqueous solution of an amino group-containing polymer formed by chains containing amino units is used as the second solution. The weight average molecular weight of the amino group-containing polymer is 1,000 to 20,000, and the pH when the first liquid and the second liquid are mixed is 5.0 to 8.0.

Description

technical field [0001] The present invention relates to medical adhesives and medical resins used for adhesion, filling, adhesion prevention, hemostasis, etc. of living tissue during surgery and other situations. In particular, it relates to a medical adhesive and a medical resin that react and solidify by mixing a first liquid and a second liquid, and then decompose and fluidize after a certain period of time. Background technique [0002] As adhesives for medical use, especially for surgical operations, (1) cyanoacrylate-based adhesives and (2) fibrin glues have been mainly used so far. [0003] (1) Cyanoacrylate adhesive [0004] At first, it was an industrial or household adhesive for the purpose of instantly bonding metal, plastic, rubber, wood, ceramics, etc., and about 10 products were developed for medical use until 1968. This kind of adhesive uses a small amount of water as a polymerization initiator to polymerize and cure cyanoacrylate monomers, and its polymeriz...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00C09J105/00C09J103/00
CPCC09J105/02C08H1/00C08L5/02A61L24/10C08B37/0021C09J189/00C08L89/00A61L24/108A61L24/08C08L2666/26A61L24/00C09J103/00C09J105/00
Inventor 中岛直喜玄丞烋近田英一
Owner BERTELSMANN MUSIC GROUP
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