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Novel method of producing strontium ranelate heptahydrate

A technology of heptahydrate and strontium ranelate, applied in the field of new preparation of strontium ranelate heptahydrate, can solve the problems of unstable water content of hydrate, troublesome practical operation, difficult purification operation, etc.

Inactive Publication Date: 2008-01-23
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this way, the octahydrate of distrontium ranelate can be produced, dried under a dry air stream to generate the heptahydrate, and dried under reduced pressure (10mmHg) at 55°C to obtain the corresponding tetrahydrate, but the preparation method is cumbersome
[0014] The second method: Add 2-[N,N-bis(carboxymethyl)amino]-3-cyano-4-carboxymethylthiophene-5-carboxylic acid tetraethyl ester to the sodium hydroxide solution mixed with alcohol and water Medium hydrolysis, after hydrolysis, the alcohol and water are evaporated to dryness to obtain a tetrasodium salt solid, and then strontium chloride is added to form a salt, but the tetrasodium salt has strong hygroscopicity, and the actual operation is also troublesome;
[0016] The applicant uses these methods, the related substance of the product that makes is higher (more than 2%), and the hydrate water content of generation is unstable, brings difficulty to the formulation of raw material quality standard and the preparation of preparation
Strontium ranelate is insoluble in most solvents, and the purification operation is quite difficult, so the products prepared by these methods are not qualified as pharmaceutical raw materials

Method used

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  • Novel method of producing strontium ranelate heptahydrate
  • Novel method of producing strontium ranelate heptahydrate
  • Novel method of producing strontium ranelate heptahydrate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Embodiment 1: Preparation of strontium ranelate heptahydrate

[0056] Weigh 400g of 2-[N,N-di(carboxymethyl)amino]-3-cyano-4-carboxymethylthiophene-5-carboxylate tetraethyl ester into the reaction flask, add 3.6L1N sodium hydroxide solution and 3.6L ethanol, heated to reflux, reacted for 4h, kept the pH value above 10 during the reaction, lowered the temperature, filtered, evaporated the filtrate to remove ethanol under reduced pressure, quantitatively added 720ml ethanol to the aqueous solution, and then added 2 times the molar amount of strontium chloride water solution, a solid precipitated. Filter, wash the filter cake layer with water 3 times, drain it, dry it in the air, add 4L of water to reflux, heat filter, wash it 3 times with boiling water, drain it, place it at room temperature, and keep the weight constant to obtain 440g. Loss on drying 19.82%, related substances 0.17%. The XRD pattern of strontium ranelate heptahydrate crystal is shown in the accompanyin...

Embodiment 2

[0057] Embodiment 2: Preparation of strontium ranelate heptahydrate

[0058]Weigh 2-[N,N-di(carboxymethyl)amino]-3-cyano-4-carboxymethylthiophene-5-carboxylic acid tetraethyl ester, add 500g into the reaction flask, add 4.5L1N sodium hydroxide solution and 4.5L ethanol, heated to reflux, reacted for 8 hours, kept the pH value at 13, cooled down, filtered, the filtrate was evaporated to remove ethanol under reduced pressure, 2250ml ethanol was added to the aqueous solution, and then a solution of 2.5 times the molar amount of strontium chloride water was added to precipitate solid. Filter, wash the filter cake layer with water 3 times, drain it, dry it in the air, add 5L of water to reflux, heat filter, wash it 3 times with boiling water, drain it, place it at room temperature, and obtain 560g at constant weight. Loss on drying 19.74%, related substances 0.08%. The XRD pattern of strontium ranelate heptahydrate crystal is shown in the accompanying drawing 1 of the description...

Embodiment 3

[0059] Embodiment 3 pharmaceutical composition

[0060] Prepare 1000 bags of granule prescriptions, each containing 1g of active ingredient

[0061] The crude drug 1246g of embodiment 1

[0062] Lactose 1800g

[0063] Microcrystalline Cellulose 1500g

[0064] Xylitol 100g

[0065] Sorbitol 100g

[0066] Methylcellulose 200g

[0067] Flavor 100g

[0068] Preparation Process:

[0069] Pass the main ingredient and auxiliary materials through a 200-mesh sieve respectively. Fully mix the excipients first, then weigh the prescribed amount of excipients and mix them fully with the main drug. Use 10% pvp water to make soft material, granulate with 20 mesh sieve, dry at 50°C, granulate with 20 mesh sieve, sieve out fine powder, and pack.

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Abstract

The invention relates to a new preparation method of strontium ranelate heptahydrate. The products produced by the method have water content of 19.0 per cent to 20.4 per cent and the relevant substances are lower than 0.5 per cent. The strontium ranelate heptahydrate produced by the method is stable under room temperature, has little water content differences between batches and is kept for a long time under natural environment with unchangeable moisture, content and relevant substances. The method is characterized in that: (1) the reflux of the 2-[N, N- 2(carboxymethyl)amino]-3-cyano-group-4-thiopheneacetic-5-carboxylic acid tetra ester (b) is carried out in the proper sodium hydroxide aqueous solution of alcohol for 5h to 6h and the pH value is kept over 10 during hydrolysis; (2) the ethanol of 20 per cent to 60 per cent is added and then the strontium chloride aqueous solution with 2times to 2.5times molal weight is directly added, precipitates the crystal, is filtered and dried; (3) water is added to carry out the reflux and the little salt packed in the crude product is removed, and the product is collected through heat filtration. The invention discloses the drug combination containing the strontium ranelate heptahydrate which is used for the treatment of osteoporosis of women after menopause.

Description

technical field [0001] The present invention relates to a new preparation method of strontium ranelate heptahydrate and a pharmaceutical composition containing it. The compound has activity in the treatment of osteoporosis in postmenopausal women. Background technique [0002] The structural formula of strontium ranelate heptahydrate is as follows: [0003] [0004] Strontium ranelate heptahydrate chemical name: [0005] 3-Thiopheneacetic acid, 5-[bis(carboxymethyl)amino]-2-carboxy-4-cyano, strontium salt(1:2)heptahydrate [0006] That is, 5-[di(carboxymethyl)amino]-2-carboxy-4-cyano-3-thiophene acetate distrontium salt heptahydrate, which has very valuable pharmacological activities, especially in anti-osteoporotic properties On the one hand, it can both inhibit bone resorption and promote bone formation, making this compound useful in the treatment of osteoporosis in postmenopausal women. [0007] EP0415850 has described the preparation and therapeutic use of stront...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D333/38A61K31/381A61P19/10
Inventor 黄汉忠李树军靳朝东任晓文薛津李洪起连潇嫣许瑞征
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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